Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development
Abstract
:1. Introduction
Molecular Virology and Genome Organization
2. Roles and Function of Non-Structural Proteins
2.1. Non-Structural Proteins (nsPs)
2.1.1. Non-Structural Protein 1 (nsP1)
2.1.2. Non-Structural Protein 2 (nsP2)
2.1.3. Non-Structural Protein 3 (nsP3)
2.1.4. Non-Structural Protein 4 (nsP4)
2.2. Viral Target Proteins for Drug Development
3. Chemotherapeutics Targeting Viral Non-Structural Proteins
3.1. Antivirals against nsP2 Protease
3.2. Inhibitors of Other nsPs
4. Concluding Remarks and Perspectives
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Non-Structural Protein | Domain Function | Virus | PDB ID | Reference |
---|---|---|---|---|
nsP1 | mRNA capping | SFV | 1FW5 | [45] |
nsP2 | NTPase/HelicaseProtease | - VEEV CHIKV SINV | - 2HWK, 5EZQ 3TRK 4GUA | - [29,30] [31] [32] |
nsP3 | Macrodomain | VEEV CHIKV SINV | 3GQE 3GPG 4GUA | [60] [60] [32] |
nsP4 | RNA-dependent RNA Polymerase | - | - | [32] |
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Abu Bakar, F.; Ng, L.F.P. Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development. Viruses 2018, 10, 71. https://doi.org/10.3390/v10020071
Abu Bakar F, Ng LFP. Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development. Viruses. 2018; 10(2):71. https://doi.org/10.3390/v10020071
Chicago/Turabian StyleAbu Bakar, Farhana, and Lisa F. P. Ng. 2018. "Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development" Viruses 10, no. 2: 71. https://doi.org/10.3390/v10020071
APA StyleAbu Bakar, F., & Ng, L. F. P. (2018). Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development. Viruses, 10(2), 71. https://doi.org/10.3390/v10020071