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Comment published on 29 January 2019, see Viruses 2019, 11(2), 117.

Open AccessArticle
Viruses 2018, 10(11), 614; https://doi.org/10.3390/v10110614

The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts

1
Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA
2
FORGE Life Science, Pennsylvania Biotechnology Center, Doylestown, PA 18901, USA
*
Authors to whom correspondence should be addressed.
Received: 17 October 2018 / Revised: 2 November 2018 / Accepted: 3 November 2018 / Published: 7 November 2018
(This article belongs to the Section Animal Viruses)
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Abstract

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells. However, latently infected individuals with weakened immune systems often undergo HCMV reactivation, which can cause serious complications in immunosuppressed and immunocompromised patients. Current anti-viral therapies target late stages of viral replication, and are often met with therapeutic resistance, necessitating the development of novel therapeutics. In this current study, we identified a naturally-occurring flavonoid compound, deguelin, which inhibits HCMV lytic replication. Our findings reveal that nanomolar concentrations of deguelin significantly suppress the production of the infectious virus. Further, we show that deguelin inhibits the lytic cycle during the phase of the replication cycle consistent with early (E) gene and protein expression. Importantly, our data reveal that deguelin inhibits replication of a ganciclovir-resistant strain of HCMV. Together, our findings identify a novel, naturally occurring compound that may prove useful in the treatment of HCMV replication. View Full-Text
Keywords: cytomegalovirus; HCMV; deguelin; ganciclovir cytomegalovirus; HCMV; deguelin; ganciclovir
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Nukui, M.; O’Connor, C.M.; Murphy, E.A. The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts. Viruses 2018, 10, 614.

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