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Fumonisin B1 Toxicity in Grower-Finisher Pigs: A Comparative Analysis of Genetically Engineered Bt Corn and non-Bt Corn by Using Quantitative Dietary Exposure Assessment Modeling

Interdepartmental Toxicology Program, Department of Agronomy, Iowa State University, Ames, IA 50011, USA
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Int. J. Environ. Res. Public Health 2011, 8(8), 3179-3190; https://doi.org/10.3390/ijerph8083179
Received: 11 May 2011 / Revised: 12 July 2011 / Accepted: 15 July 2011 / Published: 28 July 2011
(This article belongs to the Special Issue Environmental Health Risk Assessment)
In this study, we investigate the long-term exposure (20 weeks) to fumonisin B1 (FB1) in grower-finisher pigs by conducting a quantitative exposure assessment (QEA). Our analytical approach involved both deterministic and semi-stochastic modeling for dietary comparative analyses of FB1 exposures originating from genetically engineered Bacillus thuringiensis (Bt)-corn, conventional non-Bt corn and distiller’s dried grains with solubles (DDGS) derived from Bt and/or non-Bt corn. Results from both deterministic and semi-stochastic demonstrated a distinct difference of FB1 toxicity in feed between Bt corn and non-Bt corn. Semi-stochastic results predicted the lowest FB1 exposure for Bt grain with a mean of 1.5 mg FB1/kg diet and the highest FB1 exposure for a diet consisting of non-Bt grain and non-Bt DDGS with a mean of 7.87 mg FB1/kg diet; the chronic toxicological incipient level of concern is 1.0 mg of FB1/kg of diet. Deterministic results closely mirrored but tended to slightly under predict the mean result for the semi-stochastic analysis. This novel comparative QEA model reveals that diet scenarios where the source of grain is derived from Bt corn presents less potential to induce FB1 toxicity than diets containing non-Bt corn. View Full-Text
Keywords: Bacillius thuringiensis corn; Bt corn; swine diet; DDGS; fumonisin; risk assessment Bacillius thuringiensis corn; Bt corn; swine diet; DDGS; fumonisin; risk assessment
MDPI and ACS Style

Delgado, J.E.; Wolt, J.D. Fumonisin B1 Toxicity in Grower-Finisher Pigs: A Comparative Analysis of Genetically Engineered Bt Corn and non-Bt Corn by Using Quantitative Dietary Exposure Assessment Modeling. Int. J. Environ. Res. Public Health 2011, 8, 3179-3190.

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