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Article

Characterization of Tiered Psychological Distress Phenotypes in an Orthopaedic Sports Population

Duke Department of Orthopaedic Surgery, Duke University Medical Center, 200 Trent Drive, Durham, NC 27710, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2025, 22(6), 914; https://doi.org/10.3390/ijerph22060914
Submission received: 26 March 2025 / Revised: 28 May 2025 / Accepted: 4 June 2025 / Published: 9 June 2025

Abstract

:
Psychological distress and musculoskeletal pain are interconnected with poor functional outcomes. This study sought to classify common phenotypes of psychological distress in an orthopaedic sports population and assess differences in functional outcomes using the Prediction of Referral and Outcome (OSPRO-YF) tool. This was a cross-sectional study on 411 operative patients from a single sports surgeon’s clinical practice with completed OSPRO-YF questionnaires. Latent class analysis was employed to construct distress phenotypes based on binary measures for 11 single-construct psychological questionnaires, spanning two negative and one positive domains of pain-associated psychological distress. Functional outcome measures, including numerical pain scores, the Patient-Reported Outcomes Measurement Information System (PROMIS), the Single Assessment Numeric Evaluation (SANE) American Shoulder and Elbow Surgeons Score (ASES), and the International Knee Documentation Committee Subjective Knee Form (IKDC), were compared. Four psychological distress clusters were derived: low distress (LD-1; n = 111), low self-efficacy (LS-2; n = 101), negative pain coping, low self-efficacy (NP-3; n = 99), and high distress (HD-4; n = 100), with increasing yellow flags proceeding from LD-1 to HD-4. The mean numerical pain scores were highest in HD-4 and lowest in LD-1 and LS-2 (4.6 vs. 2.7 and 2.0, respectively; p < 0.001). The PROMIS depression scores were highest in HD-4 compared to NP-3, LS-2, and LD-1 (57.0 vs. 48.9 vs. 45.6 vs. 46.0; p < 0.001). Phenotyping patients based on OSPRO-YF distress indicators provides an initial framework of the psychological distress burdening the average orthopaedic sports surgical patient population and may aid in targeted psychological treatments.

1. Introduction

Despite advances in surgical techniques and evidence-based rehabilitation protocols, many patients report chronic pain and lasting dysfunction after orthopaedic sports surgeries [1,2]. There is a complex interplay between psychological distress and musculoskeletal pain [3,4,5,6]. A growing body of literature has demonstrated that psychosocial factors such as emotional distress, poor pain coping mechanisms, and reduced resiliency are associated with increased pain intensity, physical disability, poor functional outcomes, and prolonged postoperative opioid use in patients with orthopaedic sport-related injuries [7,8,9,10,11,12]. Growing awareness of the importance of psychological distress after surgery, coupled with the availability of psychological questionnaires that assess multiple domains of psychological distress (i.e., depression, fear avoidance, and self-efficacy), have created opportunities to better understand and manage these characteristics post-surgery. One such opportunity is through psychological phenotyping. Phenotyping facilitates the identification of patient subgroups that would most benefit from tailored, psychologically informed rehabilitation interventions to improve post-surgical outcomes.
However, there is a paucity of literature describing the psychological profiles that exist in an orthopaedic sports population, which is typically younger and healthier than the average osteoarthritis population [13]. One cross-sectional study deployed abbreviated questionnaires and sought to identify psychological distress phenotypes in 137 patients with shoulder pathologies, albeit limited by the sample size and the breadth of the psychological domains covered [14]. Deepening our understanding of the psychological phenotypes that exist in the orthopaedic sports population is important in identifying patients at higher risk for suboptimal outcomes and providing targeted multimodal therapy to improve patient care [15,16]. Additionally, it is important to identify these phenotypes in a surgical population in order to optimize both preoperative expectations and postoperative recovery. Therefore, the aim of this study was to identify unique psychological distress phenotypes in a sports medicine clinic at a large institution, leveraging the use of the Optimal Screening or Prediction of Referral and Outcome (OSPRO-YF), a multidimensional psychological assessment tool that measures depression, anxiety, self-efficacy, pain catastrophizing, and fear avoidance [17]. The authors hypothesized that a sports medicine population would result in fewer patients classified into high psychological distress phenotypes in comparison to older, hip and knee osteoarthritis psychological phenotypes, as evaluated in prior studies [17].

2. Methods

2.1. Cohort Selection

Institutional review board approval was obtained prior to conducting this retrospective study. Utilizing the institution’s electronic health record (EHR) database, we identified 433 patients who had completed a 10-item OSPRO-YF survey preoperatively or at the first postoperative visit between March 2020 and June 2022 and underwent an orthopaedic procedure by a single, fellowship-trained surgeon at a large academic institution. New patients were invited to complete the 10-item OSPRO-YF tool, a concise assessment tool that detects yellow flags for 11 single-construct psychological questionnaires that span 3 separate domains of pain-associated psychological distress (2 related to vulnerability and 1 to resilience) [17]. Yellow flagging is performed using OSPRO-YF tool score estimates, and patients receive flags if their score estimate is above the 75th percentile for negative psychological domains or below the 25th percentile for positive domains. The 11 psychological constructs (validated questionnaire), for which scores are estimated, include depression (Patient Health Questionnaire-9; PHQ-9), anxiety (State-Trait Anxiety Inventory; STAI), anger (State-Trait Anger Expression Inventory; STAXI), fear avoidance beliefs for physical activities and for work (Fear Avoidance Beliefs Questionnaire; FABQ-PA and FABQ-W, respectively), pain catastrophizing (Pain Catastrophizing Scale; PCS), kinesiophobia (Tampa Scale of Kinesiophobia-11; TSK-11), pain-related anxiety (Pain Anxiety Symptoms Scale-20; PASS-20), pain self-efficacy (Pain Self-Efficacy Questionnaire; PSEQ), rehabilitation self-efficacy (Self-Efficacy for Rehabilitation Outcome Scale; SER), and pain acceptance (Chronic Pain Acceptance Questionnaire; CPAQ). Patient survey responses were entered online in the medical chart prior to the visit on a personal device or using a tablet device during the visit, and surveys were completed by patients on a voluntary basis. Although the OSPRO-YF tool is offered to all patients at this surgeon’s clinic, the decision was made to include only operative patients in this analysis such that the derived psychological profiles were reflective of patients with significant orthopaedic pathologies meeting the indications for surgical treatment. In this manner, the psychologically informed treatment recommendations derived from the characteristics of our psychological distress phenotypes may best be applied to other cohorts of surgical patients. In this cohort, patients underwent mainly sports-related orthopaedic procedures such as shoulder labrum or rotator cuff repair, capsular repair or reconstruction, knee ligamentous or meniscus repair/reconstruction, chondroplasty, open reduction internal fixation, and tenodesis or tenotomy. Nine patients with incomplete OSPRO-YF surveys were also excluded. Ultimately, 411 patients with completed OSPRO-YF surveys were included for subsequent analysis.

2.2. Patient and Survey Data

Data on patient demographics and baseline characteristics, including age, race, ethnicity, sex, body mass index (BMI), current smoking status, and anesthesia type (general vs. other), were collected from the institutional EHR. Preoperative patient-reported outcomes such as numerical pain rating, Single Assessment Numeric Evaluation (SANE), Patient-Reported Outcomes Measurement Information System (PROMIS), American Shoulder and Elbow Surgeons Score (ASES), and International Knee Documentation Committee (IKDC) were also obtained. Preoperative survey data on pain, SANE, PROMIS, ASES, and IKDC were available for approximately half of the patients in this cohort (range: 49.3–57.8%).

2.3. Latent Class Analysis

A latent class analysis was performed on the 11 OSPRO yellow flag binary measures (yes or no) using the poLCA (version1.6.0.1, R package, R Core Team, Vienna, Austria) to derive classes or “phenotypes” of psychological distress in this patient cohort [18]. This probability-based classification method assigned patients to classes based on their highest posterior probability. The number of classes (k) was determined in a similar fashion to Lentz et al. [17], deriving psychological distress phenotypes in hip and knee osteoarthritis patients [19]. In brief, we considered model fit measurements such as the Akaike and Bayesian information criteria (AIC and BIC), likelihood ratio chi-squared statistic (L2), and model entropy (Table 1). Entropy was used to calculate the classification accuracy and quality, with values closer to 1 indicating clearer classification. The equation for model entropy utilized can be seen below:
E n t r o p y = 1 i 1 N k 1 K p ^ i k log ( p ^ i k ) N log ( K )
We also ensured adequate class representation (each group containing > 10% of the total cohort) and the clinical interpretability of the reported probabilities of reporting yellow flags on various questionnaires. The selected model prioritized the AIC and BIC values, significant L2 test, and high entropy. A four-class system showed the most favorable connections of these metrics (Table 2) [20].

2.4. Statistical Analysis

Continuous variables were represented as means and standard deviations, and categorical variables were represented as counts and proportions. The normality of continuous variables was assessed visually using histogram plots and quantitatively with the Shapiro–Wilk normality test. Univariable analysis was performed using analysis of variance (ANOVA) or chi-squared tests as appropriate. Patient-reported outcomes were found to be normally distributed and were subsequently analyzed with ANOVA, with post hoc comparisons performed via Tukey’s honestly significant difference (TSD) and pairwise chi-squared tests. The post hoc testing p-values were subsequently adjusted for multiple comparisons using the Benjamini–Hochberg (BH) method.

2.5. Transparency and Openness

Patient sample selection, exclusion criteria, data manipulations, and measures are reported in the above sections. All univariable statistical analyses were performed in R version 3.6.1 (R Foundation, Vienna, Austria) using the stats package version 3.6.2. p-value < 0.05 was considered to indicate a statistically significant difference. This study’s design and its analysis were approved by an IRB.

3. Results

The latent cluster analysis produced four classes based on the model fit characteristics, which considered the AIC and BIC values, significant L2, and model entropy, in addition to classes possessing > 10% of the population in each. These classes were labeled as the following, based on the estimated probabilities of obtaining yellow flags on individual psychological questionnaires: Class 1—low distress (LD-1); Class 2—low self-efficacy (LS-2); Class 3—negative pain coping, low self-efficacy (NP-3); and Class 4—high distress (HD-4). This classification method produced a tiered system of phenotypes, in which each increasing class raised yellow flags in an additional domain of psychological distress (Figure 1). In brief, HD-4 had yellow flags in both negative domains (mood and fear avoidance/catastrophizing) and the positive domain (resiliency). NP-3 differed from HD-4 by the absence of yellow flags in the mood domain. In comparison, LS-2 did not have yellow flags in any negative domain, but did have yellow flags in the positive, resiliency domain. Finally, LD-1 was our low-distress class, with relatively low probabilities of raising yellow flags in any domain. There were comparably similar numbers of patients in each class (n = 100, 99, 101, 111 for classes HD-4, NP-3, LS-2, LD-1, respectively).
In our sports patient population, LS-2 had the lowest mean patient age (39.5 yrs, sd: 18.2), while LD-1 (low distress) had the highest mean age (45.5, sd: 17.9; p = 0.028) (Table 3). The racial distribution across classes demonstrated a stepwise decrease in the proportion of White/Caucasian patients and, reversely, a stepwise increase in the proportion of Black/African American with increasing psychological distress classes (p < 0.001). A small group of “Other/Mixed/Not reported” patients also demonstrated a trend towards higher prevalence in higher-distress classes. There was no significant difference in ethnic distribution across classes. Smoking prevalence was also associated with increasing class numbers, with 14.5% of HD-4 patients compared to 2.7% of LD-1 patients being current smokers (p = 0.032). There were no statistically significant differences in sex, anesthesia type (general vs. other), or procedure type between classes.
Evaluating the patient-reported measures, we found that HD-4 had the highest mean numerical pain rating scores (4.7, sd 3.3). Compared to HD-4, LD-1 and LS-2 patients had lower mean pain scores in the pairwise post hoc analysis (2.6, sd 2.5, p < 0.001 and 2.0, sd 2.6, p < 0.001, respectively). Regarding patients undergoing surgery for shoulder pathologies (i.e., rotator cuff or labral repair), HD-4 and NP-3 patients had lower mean ASES scores (35.5 and 40.2, respectively) than LS-2 and LD-1 (60.4 and 52.3; p = 0.029), although the pairwise comparisons did not identify statistically significant differences. No significant differences were found in the ASES scores for the unaffected shoulder or for the IKDC scores. The PROMIS category scores revealed similar class trends, with HD-4 and NP-3 having higher mean pain interference scores (p = 0.007) and higher mean sleep disturbance scores (p < 0.001). The mean PROMIS depression scores were highest in HD-4 compared to NP-3, LS-2, and LD-1 (57.1 vs. 48.9 vs. 45.6 vs. 46.0; p < 0.001). Statistically significant differences from the post hoc pairwise comparisons can be found in Table 4.

4. Discussion

The present study identified four tiered psychological distress phenotypes in patients presenting for sports-related orthopaedic shoulder, knee, and foot and ankle pathologies. Compared to previous patient profiling studies in patients suffering from knee and hip osteoarthritis, there are fewer patients falling into the respective high-distress classes. This present study offers a conceptual framework to triage surgical patients according to their psychologic risk factors, with the goal of optimizing their psychological recovery after surgery.
Concise, multidimensional psychological assessment tools allow physicians to better characterize the heterogeneity of patient profiles in an orthopaedic setting [21,22,23]. The psychological distress phenotypes generated in our analysis are best interpreted in the context of phenotypes from similar patient profiling studies [14,19]. Broadly speaking, our phenotypes were similar in size (each comprising approximately a quarter of the patients, 24.1-27.0%) and demonstrated a unique, tiered pattern in which one additional psychological domain was “yellow-flagged” with rising class numbers. This was in contrast with the phenotypes identified in 1,239 patients with hip and knee osteoarthritis (OA), where a specific “negative pain coping” phenotype without yellow flags in the positive pain coping (self-efficacy) domain exists. Furthermore, over half of the OA cohort (n = 646, 52%) fell into the high-distress group, in comparison to only a quarter of our patients falling into the HD-4 group, likely related to the significant psychological burden of chronic pain, which was less prevalent in our younger sports population [24,25,26]. Comparatively, Miner et al. identified only 5 of 137 total patients with upper-extremity illness falling into their high-distress equivalent, “Phenotype 4”, with the majority (n = 77/137, 56%) of patients in their low-distress equivalent, “Phenotype 1” [14]. In our cohort, which included patients with shoulder pathologies (rotator cuff, labral, and capsular injury), we did not detect a disproportionate number of shoulder procedures in our low-distress class (Table 3, p = 0.615). The differences in our distress group proportions may be due to differences in the sample size, our study’s inclusion of only patients undergoing surgery, or survey method differences, with our study’s utilization of a multidimensional assessment tool that provided estimates across more psychological constructs.
Across our phenotypes, the patient-reported outcome measures depict a general trend toward worse functional scores in higher-distress classes, although the HD-4 and NP-3 classes demonstrated similar pain, function, and demographic profiles. The findings suggest that our analysis had sufficient resolution to identify a low-self-efficacy group that may be indifferentiable from the low-distress class when only assessing function- or pain-related measures but harbor a distinct psychological profile with a significant likelihood of raising yellow flags across self-efficacy and chronic pain acceptance measures. As our OSPRO-YF measurements were obtained either preoperatively or shortly after surgery at the patients’ first postoperative visit, we were unable to assess the long-term differences between these groups. For example, it may be that patients within the low-self-efficacy group are less likely to participate meaningfully in physical therapy during their postoperative rehabilitation, in turn leading to slower or overall worse functional recovery. Similarly, these patients may be more sensitive to ongoing postoperative pain and therefore less satisfied with their overall recovery. Further research on the temporal dynamicity of psychological profiles is warranted to better inform psychological interventions in recovery from musculoskeletal injury.
The utility of preoperative phenotyping is that, by classifying patients into four phenotype profiles, surgeons can offer specific, personalized treatments to address these psychological vulnerabilities, as outlined below for each phenotype.
(1)
Patients in HD-4 may be most likely to benefit from early psychosocial interventions and more frequent monitoring. Cognitive behavioral therapy (CBT) is highly effective in reducing psychological distress following surgery and improves long-term scores for quality of life and reduced anxiety [27], but it is time-intensive and can be expensive for the patient. Because psychological interventions can be resource-intensive, it is important to limit referrals for CBT to patients that are most likely to benefit from it, such as patients with a HD-4 phenotype.
(2)
Patients in NP-3 (poor pain coping and low self-efficacy) may benefit from lower-intensity interventions to enhance coping and self-efficacy, such as coping model video interventions, where models perform rehabilitation exercises, reflect on problems faced, and discuss strategies to overcome them in one preoperative and one postoperative video (total duration of 16 min) [28]. Coping model interventions are aimed at reducing anxiety and perceptions of pain, which is thought to improve self-efficacy and function in the postoperative rehabilitation period [29,30,31]. Studies have also demonstrated the efficacy of combining education led by a physical therapist with impairment-based interventions in lowering both pain catastrophizing scores and coping skill strategies [32,33,34,35]. Specifically, one-on-one pain neuroscience education (helping patients to re-conceptualize their pain from a neurobiological perspective) with information booklets is another option for lower-intensity intervention.
(3)
Patients in LS-2 may be most likely to naturally transition to a low-distress phenotype over the course of routine rehabilitation as their confidence in physical activity improves. For this reason, these patients may benefit most from a “wait and see” approach, where traditional rehabilitation is offered and psychological distress is monitored over the first 4–6 weeks of rehabilitation to determine whether psychologically focused interventions are warranted.
(4)
Finally, those in LD-1 would be the best candidates for traditional impairment-based rehabilitation, may not require any psychological monitoring, and may be good candidates for low-touch treatment pathways like self-directed care and telehealth [36] (Figure 2).
This conceptual framework for psychological support and treatment offered to patients falling into different classes is visualized in Figure 2.
There are several limitations to this study. Notably, the 10-item OSPRO-YF, developed through iterative item reduction from a 136-item pool, produces accurate estimates for individual questionnaires but is not equivalent to completing full individual psychological questionnaires, which limits our profiling accuracy. Additionally, yellow flags are population-based labels (below 25th or above 75th percentiles) and may not always reflect clinically significant thresholds. The phenotypes discerned from our study, with questionnaires collected pre- or postoperatively at patients’ first visits, should only be interpreted as static profiles, as the temporal dynamicity of the OSPRO-YF responses has not been evaluated. Therefore, the timing of survey administration is a potential cofounder in this study. As our study lacks a follow-up, we are unable to correlate the phenotypes with the recovery trajectories, which could be considered in a future investigation. Lastly, our single-surgeon, single-institution cohort was selected to minimize heterogeneity in the data collection methods, which inherently affects the generalizability of this study’s findings. Our cohort consisted of 411 patients, which, while large, may not fully capture the diversity of this population. Nevertheless, with the ability of our clustering analysis to detect distinct psychological profiles, we believe that our study findings provide novel contributions to the current understanding of psychological pain distress phenotypes in the orthopaedic sports population.

5. Conclusions

This study describes the novel characterization of tiered psychological distress phenotypes in an orthopaedic sports population. Similarly to prior studies, we detected high- and low-distress groups, although we found relatively fewer patients in the high-distress groups, as seen in hip and knee osteoarthritis cohorts. The present study also found racial disparities across psychological phenotypes, emphasizing the importance of addressing the increased psychological burden in racial minority groups, even in a relatively young and healthy orthopaedic sports population. This study provides a framework for the characterization of the heterogeneity of patient psychological profiles and allows sports medicine practitioners to better understand this population. Providers should consider implementing new classification systems, such as the one described in this study, to optimize psychological interventions offered to patients after surgery, particularly those facing higher levels of distress.

Author Contributions

Conceptualization, B.I.K. and N.J.M.; methodology, B.I.K.; software, B.I.K.; validation, B.I.K., N.J.M. and T.A.L.; formal analysis, N.J.M.; investigation, B.I.K.; resources, B.I.K.; data curation, B.I.K. and N.J.M.; writing—original draft preparation, B.I.K., T.P.S., J.E.R. and C.N.P.; writing—review and editing, all authors; visualization, B.I.K. and N.J.M.; supervision, B.C.L.; project administration, T.A.L. and B.C.L.; funding acquisition, none. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

This study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of Duke University Heath System (code: Pro00110198-INIT-1.0) on 22 February 2022.

Informed Consent Statement

Patient consent was waived due to retrospective nature of this study.

Data Availability Statement

The original contributions presented in this study are included in the article. Further inquiries can be directed to the corresponding authors.

Conflicts of Interest

The authors declare no conflicts of interest that are related to the nature of this study.

Abbreviations

The following abbreviations are used in this manuscript:
OSPRO-YFOptimal Screening or Prediction of Referral and Outcome—Yellow Flag
PROMISPatient-Reported Outcomes Measurement Information System
ASESAmerican Shoulder and Elbow Surgeons Score
IKDCInternational Knee Documentation Committee Subjective Knee Form
EHR Electronic Health Record
PHQ-9Patient Health Questionnaire-9
STAIState-Trait Anxiety Inventory
STAXIState-Trait Anger Expression Inventory
FABQFear Avoidance Beliefs Questionnaire
TSK-11Tampa Scale of Kinesaphobia-11
PCSPain Catastrophizing Scale
SERSelf-Efficacy for Rehabilitation Outcome Scale
CPAQChronic Pain Acceptance Questionnaire
BMIBody Mass Index
SANESingle Assessment Numerical Evaluation
AICAkaike Information Criterion
BICBayesian Information Criterion
ANOVAAnalysis of Variance
HSDHonestly Significant Difference
BHBenjamini–Hochberg
HD-4High Distress Class 4
LD-1Low Distress Class
LS-2Low Self-Efficacy Class 2
NP-3Negative Pain Coping Class 3

References

  1. Samitier, G.; Marcano, A.I.; Alentorn-Geli, E.; Cugat, R.; Farmer, K.W.; Moser, M.W. Failure of Anterior Cruciate Ligament Reconstruction. Arch. Bone Jt. Surg. 2015, 3, 220–240. [Google Scholar]
  2. Matsuki, K.; Sugaya, H. Complications after arthroscopic labral repair for shoulder instability. Curr. Rev. Musculoskelet. Med. 2015, 8, 53–58. [Google Scholar] [CrossRef] [PubMed]
  3. Poleshuck, E.L.; Bair, M.J.; Kroenke, K.; Damush, T.M.; Tu, W.; Wu, J.; Krebs, E.E.; Giles, D.E. Psychosocial stress and anxiety in musculoskeletal pain patients with and without depression. Gen. Hosp. Psychiatry 2009, 31, 116–122. [Google Scholar] [CrossRef] [PubMed]
  4. Piussi, R.; Krupic, F.; Senorski, C.; Svantesson, E.; Sundemo, D.; Johnson, U.; Senorski, E.H. Psychological impairments after ACL injury—Do we know what we are addressing? Experiences from sports physical therapists. Scand. J. Med. Sci. Sports 2021, 31, 1508–1517. [Google Scholar] [CrossRef]
  5. Bullock, G.S.; Sell, T.C.; Zarega, R.; Reiter, C.; King, V.; Wrona, H.; Mills, N.; Ganderton, C.; Duhig, S.; Raisasen, A.; et al. Kinesiophobia, Knee Self-Efficacy, and Fear Avoidance Beliefs in People with ACL Injury: A Systematic Review and Meta-Analysis. Sports Med. 2022, 52, 3001–3019. [Google Scholar] [CrossRef]
  6. Carriere, J.S.; Pimentel, S.D.; Yakobov, E.; Edwards, R.R. A Systematic Review of the Association Between Perceived Injustice and Pain-Related Outcomes in Individuals with Musculoskeletal Pain. Pain Med. 2020, 21, 1449–1463. [Google Scholar] [CrossRef] [PubMed]
  7. Ackerman, I.N.; Ademi, Z.; Osborne, R.H.; Liew, D. Comparison of Health-Related quality of life, work status, and health care utilization and costs according to hip and knee joint disease severity: A national Australian study. Phys. Ther. 2013, 93, 889–899. [Google Scholar] [CrossRef]
  8. Filbay, S.R.; Ackerman, I.N.; Russell, T.G.; Macri, E.M.; Crossley, K.M. Health-Related quality of life after anterior cruciate ligament reconstruction: A systematic review. Am. J. Sports Med. 2014, 42, 1247–1255. [Google Scholar] [CrossRef]
  9. Ackerman, I.N.; Fotis, K.; Pearson, L.; Schoch, P.; Broughton, N.; Brennan-Olsen, S.L.; Bucknill, A.; Cross, E.; Bunting-Frame, N.; Page, R.S. Impaired Health-Related quality of life, psychological distress, and productivity loss in younger people with persistent shoulder pain: A cross-sectional analysis. Disabil. Rehabil. 2022, 44, 3785–3794. [Google Scholar] [CrossRef]
  10. Piva, S.R.; Fitzgerald, G.K.; Wisniewski, S.; Delitto, A. Predictors of pain and function outcome after rehabilitation in patients with patellofemoral pain syndrome. J. Rehabil. Med. 2009, 41, 604–612. [Google Scholar] [CrossRef]
  11. Flor, H.; Turk, D.C. Chronic back pain and rheumatoid arthritis: Predicting pain and disability from cognitive variables. J. Behav. Med. 1988, 11, 251–265. [Google Scholar] [CrossRef] [PubMed]
  12. Castle, J.P.; Jildeh, T.R.; Buckley, P.J.; Abbas, M.J.; Mumuni, S.; Okoroha, K.R. Older, Heavier, Arthritic, Psychiatrically Disordered, and Opioid-Familiar Patients Are at Risk for Opioid Use After Medial Patellofemoral Ligament Reconstruction. Arthrosc. Sports Med. Rehabil. 2021, 3, e2025–e2031. [Google Scholar] [CrossRef]
  13. Levin, J.M.; Baker, R.; Goltz, D.E.; Wickman, J.; Lentz, T.A.; Cook, C.; George, S.Z.; Klifto, C.S.; Anakwenze, O.A. Heterogeneity of Pain-Related psychological distress in patients seeking care for shoulder pathology. J. Shoulder Elb. Surg. 2022, 31, 681–687. [Google Scholar] [CrossRef] [PubMed]
  14. Miner, H.; Rijk, L.; Thomas, J.; Ring, D.; Reichel, L.M.; Fatehi, A. Mental-Health Phenotypes and Patient-Reported Outcomes in Upper-Extremity Illness. J. Bone Jt. Surg. Am. 2021, 103, 1411–1416. [Google Scholar] [CrossRef]
  15. Castro, M.M.; Daltro, C.; Kraychete, D.C.; Lopes, J. The cognitive behavioral therapy causes an improvement in quality of life in patients with chronic musculoskeletal pain. Arq. Neuropsiquiatr. 2012, 70, 864–868. [Google Scholar] [CrossRef]
  16. Olason, M.; Andrason, R.H.; Jonsdottir, I.H.; Kristbergsdottir, H.; Jensen, M.P. Cognitive Behavioral Therapy for Depression and Anxiety in an Interdisciplinary Rehabilitation Program for Chronic Pain: A Randomized Controlled Trial with a 3-Year Follow-up. Int. J. Behav. Med. 2018, 25, 55–66. [Google Scholar] [CrossRef]
  17. Lentz, T.A.; Beneciuk, J.M.; Bialosky, J.E.; Zeppieri, G., Jr.; Dai, Y.; Wu, S.S.; George, S.Z. Development of a Yellow Flag Assessment Tool for Orthopaedic Physical Therapists: Results From the Optimal Screening for Prediction of Referral and Outcome (OSPRO) Cohort. J. Orthop. Sports Phys. Ther. 2016, 46, 327–343. [Google Scholar] [CrossRef] [PubMed]
  18. Sinha, P.; Calfee, C.S.; Delucchi, K.L. Practitioner’s Guide to Latent Class Analysis: Methodological Considerations and Common Pitfalls. Crit. Care Med. 2021, 49, e63–e79. [Google Scholar] [CrossRef]
  19. Lentz, T.A.; George, S.Z.; Manickas-Hill, O.; Malay, M.R.; O’Donnell, J.; Jayakumar, P.; Jiranek, W.; Mather, R.C., 3rd. What General and Pain-Associated Psychological Distress Phenotypes Exist Among Patients with Hip and Knee Osteoarthritis? Clin. Orthop. Relat. Res. 2020, 478, 2768–2783. [Google Scholar] [CrossRef]
  20. Vermunt, J.K.; Magidson, J. Latent Gold 4.0 User’s Guide; Statistical Innovations Inc.: Belmont, MA, USA, 2005. [Google Scholar]
  21. Pincus, T.; Schmukler, J.; Castrejon, I. Patient questionnaires in osteoarthritis: What patients teach doctors about their osteoarthritis on a multidimensional health assessment questionnaire (MDHAQ) in clinical trials and clinical care. Clin. Exp. Rheumatol. 2019, 37 (Suppl. 120), 100–111. [Google Scholar]
  22. Hill, J.C.; Dunn, K.M.; Main, C.J.; Hay, E.M. Subgrouping low back pain: A comparison of the STarT Back Tool with the Orebro Musculoskeletal Pain Screening Questionnaire. Eur. J. Pain 2010, 14, 83–89. [Google Scholar] [CrossRef]
  23. Linton, S.J.; Hallden, K. Can we screen for problematic back pain? A screening questionnaire for predicting outcome in acute and subacute back pain. Clin. J. Pain 1998, 14, 209–215. [Google Scholar] [CrossRef] [PubMed]
  24. Treede, R.D.; Rief, W.; Barke, A.; Aziz, Q.; Bennett, M.I.; Benoliel, R.; Cohen, M.; Evers, S.; Finnerup, N.B.; First, M.B.; et al. Chronic pain as a symptom or a disease: The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain 2019, 160, 19–27. [Google Scholar] [CrossRef]
  25. Kittelson, A.J.; George, S.Z.; Maluf, K.S.; Stevens-Lapsley, J.E. Future directions in painful knee osteoarthritis: Harnessing complexity in a heterogeneous population. Phys. Ther. 2014, 94, 422–432. [Google Scholar] [CrossRef]
  26. Rundell, S.D.; Goode, A.P.; Suri, P.; Heagerty, P.J.; Comstock, B.A.; Friedly, J.L.; Gold, L.S.; Bauer, Z.; Avins, A.L.; Nedeljkovic, S.S.; et al. Effect of Comorbid Knee and Hip Osteoarthritis on Longitudinal Clinical and Health Care Use Outcomes in Older Adults With New Visits for Back Pain. Arch. Phys. Med. Rehabil. 2017, 98, 43–50. [Google Scholar] [CrossRef] [PubMed]
  27. Szeverenyi, C.; Kekecs, Z.; Johnson, A.; Elkins, G.; Csernatony, Z.; Varga, K. The Use of Adjunct Psychosocial Interventions Can Decrease Postoperative Pain and Improve the Quality of Clinical Care in Orthopedic Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J. Pain 2018, 19, 1231–1252. [Google Scholar] [CrossRef] [PubMed]
  28. Maddison, R.; Prapavessis, H.; Clatworthy, M. Modeling and rehabilitation following anterior cruciate ligament reconstruction. Ann. Behav. Med. 2006, 31, 89–98. [Google Scholar] [CrossRef]
  29. Flint, F.A. The Psychological Effects of Modeling in Athletic Injury Rehabilitation. Ph.D. Thesis, University of Oregon, Eugene, OR, USA, 1991. [Google Scholar]
  30. Flint, F. Integrating sport psychology and sports medicine in research. J. Appl. Sport Psychol. 1997, 10, 83–102. [Google Scholar] [CrossRef]
  31. De Carlo, M.S.; Sell, K.E.; Shelbourne, K.D.; Klootwyk, T.E. Current concepts on accelerated ACL rehabilitation. J. Sport Rehabil. 1994, 3, 304–318. [Google Scholar] [CrossRef]
  32. Louw, A.; Puentedura, E.J.; Diener, I.; Peoples, R.R. Preoperative therapeutic neuroscience education for lumbar radiculopathy: A single-case fMRI report. Physiother. Theory Pract. 2015, 31, 496–508. [Google Scholar] [CrossRef]
  33. Louw, A.; Rico, D.; Langerwerf, L.; Maiers, N.; Diener, I.; Cox, T. Preoperative pain neuroscience education for shoulder surgery: A case series. S. Afr. J. Physiother. 2020, 76, 1417. [Google Scholar] [CrossRef] [PubMed]
  34. Lluch, E.; Duenas, L.; Falla, D.; Baert, I.; Meeus, M.; Sanchez-Frutos, J.; Nijs, J. Preoperative Pain Neuroscience Education Combined With Knee Joint Mobilization for Knee Osteoarthritis: A Randomized Controlled Trial. Clin. J. Pain 2018, 34, 44–52. [Google Scholar] [CrossRef] [PubMed]
  35. Gibson, E.; Sabo, M.T. Can pain catastrophizing be changed in surgical patients? A scoping review. Can. J. Surg. 2018, 61, 311–318. [Google Scholar] [CrossRef]
  36. Stearns, Z.R.; Carvalho, M.L.; Beneciuk, J.M.; Lentz, T.A. Screening for Yellow Flags in Orthopaedic Physical Therapy: A Clinical Framework. J. Orthop. Sports Phys. Ther. 2021, 51, 459–469. [Google Scholar] [CrossRef] [PubMed]
Figure 1. Tiered phenotype classification system.
Figure 1. Tiered phenotype classification system.
Ijerph 22 00914 g001
Figure 2. Phenotype outlines and suggested treatments.
Figure 2. Phenotype outlines and suggested treatments.
Ijerph 22 00914 g002
Table 1. Model fit parameters for number of k classes.
Table 1. Model fit parameters for number of k classes.
Model—Number of Classes (k)dfBICAICLikelihood RatioEntropy
14006062.536073.532454.8055-
23884887.784910.781207.82780.931
33764646.534681.53894.36030.956
4 *3644509.194556.19684.79530.929
53524463.114522.11566.48810.952
63404444.324515.32475.4760.911
* Ideal classification system balances high entropy (close to 1) and a high likelihood ratio with lower BIC and AIC values.
Table 2. Model class membership for number of k classes.
Table 2. Model class membership for number of k classes.
Model—Number of Classes (k)Class 1Class 2Class 3Class 4Class 5Class 6
243.80%56.20%----
342.09%28.22%29.68%---
4 *24.33%24.09%24.57%27.01%--
518.20%9.25%22.87%24.33%25.30%
625.30%18.00%8.52%6.60%18.25%23.36%
k = number of classes. * Ideal model has all classes with relatively similar numbers of patients.
Table 3. Patient demographics, baseline characteristics, and procedures.
Table 3. Patient demographics, baseline characteristics, and procedures.
HD-4NP-3LS-2LD-1p-Value
N10099101111
Age, mean (sd)39.84 (17.52)44.42 (18.32)39.49 (18.19)45.49 (17.90)0.028
Race, n (%) <0.001
Caucasian/White45 (45.0)62 (62.6)72 (71.3)90 (81.1)
Black or African American43 (43.0)27 (27.3)18 (17.8)16 (14.4)
Other/Mixed/Not Reported12 (12.0)10 (10.1)11 (10.9)5 (4.5)
Ethnicity = Hispanic (%)31 (47.0)29 (50.0)39 (63.9)40 (56.3)0.235
Male Sex, n (%)4 (4.2)7 (7.4)5 (5.2)5 (4.8)0.784
BMI (kg/m2), mean (sd)31.30 (7.61)29.60 (7.37)28.43 (6.17)28.94 (6.35)0.084
Current Smoker, n (%)10 (14.5)7 (10.3)3 (4.3)2 (2.7)0.032
General Anesthesia (vs. Other), n (%)11 (16.4)8 (11.8)4 (5.9)7 (9.3)0.247
Procedure, n (%)----0.458
-----Totals
AC Joint/Clavicle Resection12 (2.9)1 (1.0)4 (4.0)2 (2.0)5 (4.5)
ACL, PCL, or Other Ligamentous Repair63 (15.3)16 (16.0)14 (14.1)18 (17.8)15 (13.5)
LUA/MUA2 (0.5)1 (1.0)1 (1.0)0 (0.0)0 (0.0)
Meniscus/Chondroplasty145 (35.3)37 (37.0)37 (37.4)32 (31.7)39 (35.1)
MPFL Recon12 (2.9)3 (3.0)2 (2.0)5 (5.0)2 (1.8)
ORIF43 (10.5)12 (12.0)9 (9.1)11 (10.9)11 (9.9)
Other/Unspecified4 (1.0)0 (0.0)0 (0.0)2 (2.0)2 (1.8)
Rotator Cuff Repair60 (14.6)13 (13.0)20 (20.2)14 (13.9)13 (11.7)
Shoulder Labral/Capsule Repair33 (8.0)13 (13.0)5 (5.1)7 (6.9)8 (7.2)
Tenodesis/Tenotomy37 (9.0)4 (4.0)7 (7.1)10 (9.9)16 (14.4)
Abbreviations: HD-4 = high distress class 4; NP-3 = negative pain coping, low self-efficacy class 3; LS-2 = low self-efficacy class 2; LD-1 = low distress class 1; BMI = body mass index; AC = acromioclavicular; ACL = anterior cruciate ligament; PCL = posterior cruciate ligament; I&D = irrigation and debridement; LOA/MUA = lysis of adhesions/manipulation under anesthesia; MPFL = medial patellofemoral ligament; ORIF = open reduction internal fixation.
Table 4. Preoperative patient-reported outcomes.
Table 4. Preoperative patient-reported outcomes.
HD-4NP-3LS-2LD-1p-ValuePost Hoc Pairwise Differences *
N10099101111
Pain, mean (sd)4.61 (3.30)3.71 (2.95)2.03 (2.62)2.66 (2.50)<0.001 *4-2; 4-1; 3-2
SANE, mean (sd)36.97 (26.88)41.44 (26.14)43.61 (31.17)48.07 (26.19)0.153
ASES, mean (sd)35.52 (21.49)40.22 (26.03)60.42 (28.31)52.25 (15.57)0.029 *none
ASES unaffected side, mean (sd)80.33 (27.17)88.70 (20.77)96.94 (4.76)88.50 (21.61)0.439
IKDC, mean (sd)30.76 (21.61)33.43 (15.36)37.06 (17.90)38.25 (14.58)0.334
IKDC unaffected side, mean (sd)77.80 (20.45)79.40 (24.76)84.33 (20.35)88.67 (16.89)0.188
PROMIS category, mean (sd)
      Physical Function33.58 (8.66)35.02 (10.91)36.35 (9.44)38.19 (9.45)0.091
      Pain Interference67.08 (7.11)63.49 (7.84)60.84 (8.52)61.46 (6.85)<0.001 *4-2; 4-1
      Sleep Disturbance59.36 (11.25)53.90 (9.79)51.59 (6.67)52.18 (9.85)0.007 *none
      Depression57.05 (10.88)48.91 (9.64)45.61 (8.05)45.96 (8.20)<0.001 *4-3; 4-2; 4-1
* statistically significant differences (p < 0.05) from pairwise comparisons after p-value correction for multiple comparisons. Abbreviations: HD-4 = high distress class 4; NP-3 = negative pain coping, low self-efficacy class 3; LS-2 = low self-efficacy class 2; LD-1 = low distress class 1; SANE = Single Assessment Numeric Evaluation; PROMIS = Patient-Reported Outcomes Measurement Information System; ASES = American Shoulder and Elbow Surgeons Score; IKDC = International Knee Documentation Committee.
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Kim, B.I.; Morriss, N.J.; Stauffer, T.P.; Ralph, J.E.; Park, C.N.; Lentz, T.A.; Lau, B.C. Characterization of Tiered Psychological Distress Phenotypes in an Orthopaedic Sports Population. Int. J. Environ. Res. Public Health 2025, 22, 914. https://doi.org/10.3390/ijerph22060914

AMA Style

Kim BI, Morriss NJ, Stauffer TP, Ralph JE, Park CN, Lentz TA, Lau BC. Characterization of Tiered Psychological Distress Phenotypes in an Orthopaedic Sports Population. International Journal of Environmental Research and Public Health. 2025; 22(6):914. https://doi.org/10.3390/ijerph22060914

Chicago/Turabian Style

Kim, Billy I., Nicholas J. Morriss, Taylor P. Stauffer, Julia E. Ralph, Caroline N. Park, Trevor A. Lentz, and Brian C. Lau. 2025. "Characterization of Tiered Psychological Distress Phenotypes in an Orthopaedic Sports Population" International Journal of Environmental Research and Public Health 22, no. 6: 914. https://doi.org/10.3390/ijerph22060914

APA Style

Kim, B. I., Morriss, N. J., Stauffer, T. P., Ralph, J. E., Park, C. N., Lentz, T. A., & Lau, B. C. (2025). Characterization of Tiered Psychological Distress Phenotypes in an Orthopaedic Sports Population. International Journal of Environmental Research and Public Health, 22(6), 914. https://doi.org/10.3390/ijerph22060914

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