Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis
Abstract
:1. Introduction
2. Methods
2.1. Study Design and Participants
2.2. Study Procedures
2.3. Retinal Images
2.4. WMH Evaluation Using ARIA
2.5. Lifestyle Changes Assessment Using HPLP-II
2.6. Statistical Analysis
3. Results
3.1. Participant Characteristics
3.2. ARIA-WMH Scores
3.3. HPLP-II Scores
3.4. Univariate Analysis of ARIA-WMH
3.5. Association between Changes in ARIA-WMH and HPLP-II Domains
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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N | % | ARIA-WMH Change | |||
---|---|---|---|---|---|
Mean | SD | p | |||
Gender | |||||
Female | 147 | 76.2 | −0.002 | 0.12 | 0.94 |
Male | 46 | 23.8 | −0.004 | 0.13 | |
Age | |||||
<65 | 139 | 72.0 | −0.004 | 0.13 | 0.82 |
≥65 | 54 | 28.0 | 0.0004 | 0.10 | |
BMI (kg/m2) | |||||
Desirable | 131 | 68.6 | −0.012 | 0.13 | 0.08 |
Overweight and Obese | 60 | 31.4 | 0.018 | 0.10 | |
Missing | 2 | ||||
Waist-hip ratio | |||||
Normal | 109 | 57.1 | −0.008 | 0.14 | 0.42 |
High | 82 | 42.9 | 0.006 | 0.10 | |
Missing | 2 | ||||
Hypertension | |||||
No | 119 | 61.7 | −0.005 | 0.12 | 0.77 |
Yes | 74 | 38.3 | 0.0005 | 0.12 | |
Diabetes Mellitus | |||||
No | 160 | 85.6 | −0.008 | 0.13 | 0.03 * |
Yes | 27 | 14.4 | 0.034 | 0.08 | |
Missing | 6 | ||||
Family history of CVD | |||||
No | 79 | 42.0 | −0.003 | 0.14 | 0.94 |
Yes | 109 | 58.0 | −0.002 | 0.11 | |
Missing | 5 | ||||
Tx for cholesterol | |||||
No | 130 | 71.8 | −0.007 | 0.13 | 0.35 |
Yes | 51 | 28.2 | 0.010 | 0.10 | |
Missing | 12 | ||||
Smoking | |||||
Non-Smoker | 188 | 97.4 | −0.003 | 0.12 | 0.12 |
Smoker | 5 | 2.6 | 0.025 | 0.03 | |
Drinking | |||||
Non-drinker | 151 | 78.2 | −0.009 | 0.12 | 0.17 |
Drinker | 42 | 21.8 | 0.021 | 0.13 |
ARIA-WMH Scores | Baseline | One-Year |
---|---|---|
N (%) | N (%) | |
Mean ± SD | 0.344 ± 0.17 | 0.341 ± 0.17 |
<0.4 | 118 (61.1) | 118 (61.1) |
0.4~0.6 | 64 (33.2) | 59 (30.6) |
>0.6 | 11 (5.7) | 16 (8.3) |
ARIA-WMH Change Score | N | % |
Mean ± SD | −0.003 | 0.12 |
<−0.1 | 29 | 15.1 |
−0.1~0.01 | 67 | 34.7 |
0~0.1 | 67 | 34.7 |
>0.1 | 30 | 15.5 |
Scale and Subscales | Question Number | Baseline | One-Year | Mean Item Score Change | ||
---|---|---|---|---|---|---|
Total Scores | Mean Item Score | Total Scores | Mean Item Score | |||
Total | 52 | 138.96 ± 20.93 | 2.67 ± 0.40 | 141.97 ± 21.85 | 2.73 ± 0.42 | 0.06 ± 0.019 * |
IR | 9 | 25.32 ± 4.08 | 2.81 ± 0.45 | 25.77 ± 4.22 | 2.86 ± 0.47 | 0.05 ± 0.024 * |
SG | 9 | 25.07 ± 4.79 | 2.79 ± 0.53 | 25.63 ± 4.99 | 2.85 ± 0.55 | 0.06 ± 0.026 * |
NU | 9 | 24.82 ± 3.98 | 2.76 ± 0.44 | 25.42 ± 3.76 | 2.82 ± 0.42 | 0.07 ± 0.022 * |
SM | 8 | 21.19 ± 3.79 | 2.65 ± 0.47 | 21.53 ± 3.90 | 2.69 ± 0.49 | 0.04 ± 0.027 |
HR | 9 | 22.67 ± 4.22 | 2.52 ± 0.47 | 23.36 ± 4.50 | 2.60 ± 0.50 | 0.08 ± 0.029 * |
PA | 8 | 19.89 ± 4.95 | 2.49 ± 0.62 | 20.27 ± 4.90 | 2.53 ± 0.61 | 0.05 ± 0.028 |
Diabetes Subgroup | HR | N | % | ARIA-WMH Change | ||
---|---|---|---|---|---|---|
Mean | SD | p | ||||
Non-diabetes | negative | 85 | 53.13 | 0.02 | 0.13 | 0.003 |
positive | 75 | 46.88 | −0.04 | 0.12 | ||
Diabetes | negative | 12 | 44.44 | 0.04 | 0.09 | 0.691 |
positive | 15 | 55.56 | 0.05 | 0.05 |
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Lai, M.; Lee, J.; Li, X.; Kwok, C.; Chong, M.; Zee, B. Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis. Int. J. Environ. Res. Public Health 2023, 20, 3530. https://doi.org/10.3390/ijerph20043530
Lai M, Lee J, Li X, Kwok C, Chong M, Zee B. Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis. International Journal of Environmental Research and Public Health. 2023; 20(4):3530. https://doi.org/10.3390/ijerph20043530
Chicago/Turabian StyleLai, Maria, Jack Lee, Xinxin Li, Chloe Kwok, Marc Chong, and Benny Zee. 2023. "Lifestyle Changes Reduced Estimated White Matter Hyperintensities Based on Retinal Image Analysis" International Journal of Environmental Research and Public Health 20, no. 4: 3530. https://doi.org/10.3390/ijerph20043530