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Article

Circulating Peptidome Is Strongly Altered in COVID-19 Patients

by
Gianluca Baldanzi
1,2,†,
Beatrice Purghè
1,2,†,
Beatrice Ragnoli
3,
Pier Paolo Sainaghi
1,4,
Roberta Rolla
5,
Annalisa Chiocchetti
2,5,
Marcello Manfredi
1,2,* and
Mario Malerba
1,3
1
Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy
2
Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, 28100 Novara, Italy
3
Respiratory Unit, Sant’Andrea Hospital, 13100 Vercelli, Italy
4
Internal and Emergency Medicine Department, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy
5
Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2023, 20(2), 1564; https://doi.org/10.3390/ijerph20021564
Submission received: 17 November 2022 / Revised: 6 January 2023 / Accepted: 11 January 2023 / Published: 14 January 2023
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Abstract

Whilst the impact of coronavirus disease 2019 (COVID-19) on the host proteome, metabolome, and lipidome has been largely investigated in different bio-fluids, to date, the circulating peptidome remains unexplored. Thus, the present study aimed to apply an untargeted peptidomic approach to provide insight into alterations of circulating peptides in the development and severity of SARS-CoV-2 infection. The circulating peptidome from COVID-19 severe and mildly symptomatic patients and negative controls was characterized using LC-MS/MS analysis for identification and quantification purposes. Database search and statistical analysis allowed a complete characterization of the plasma peptidome and the detection of the most significant modulated peptides that were impacted by the infection. Our results highlighted not only that peptide abundance inversely correlates with disease severity, but also the involvement of biomolecules belonging to inflammatory, immune-response, and coagulation proteins/processes. Moreover, our data suggested a possible involvement of changes in protein degradation patterns. In the present research, for the first time, the untargeted peptidomic approach enabled the identification of circulating peptides potentially playing a crucial role in the progression of COVID-19.
Keywords: COVID-19; peptidomics; protein degradation; biomarkers; respiratory disease COVID-19; peptidomics; protein degradation; biomarkers; respiratory disease
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MDPI and ACS Style

Baldanzi, G.; Purghè, B.; Ragnoli, B.; Sainaghi, P.P.; Rolla, R.; Chiocchetti, A.; Manfredi, M.; Malerba, M. Circulating Peptidome Is Strongly Altered in COVID-19 Patients. Int. J. Environ. Res. Public Health 2023, 20, 1564. https://doi.org/10.3390/ijerph20021564

AMA Style

Baldanzi G, Purghè B, Ragnoli B, Sainaghi PP, Rolla R, Chiocchetti A, Manfredi M, Malerba M. Circulating Peptidome Is Strongly Altered in COVID-19 Patients. International Journal of Environmental Research and Public Health. 2023; 20(2):1564. https://doi.org/10.3390/ijerph20021564

Chicago/Turabian Style

Baldanzi, Gianluca, Beatrice Purghè, Beatrice Ragnoli, Pier Paolo Sainaghi, Roberta Rolla, Annalisa Chiocchetti, Marcello Manfredi, and Mario Malerba. 2023. "Circulating Peptidome Is Strongly Altered in COVID-19 Patients" International Journal of Environmental Research and Public Health 20, no. 2: 1564. https://doi.org/10.3390/ijerph20021564

APA Style

Baldanzi, G., Purghè, B., Ragnoli, B., Sainaghi, P. P., Rolla, R., Chiocchetti, A., Manfredi, M., & Malerba, M. (2023). Circulating Peptidome Is Strongly Altered in COVID-19 Patients. International Journal of Environmental Research and Public Health, 20(2), 1564. https://doi.org/10.3390/ijerph20021564

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