The Assessment of Prolonged Inferior Alveolar Nerve Blockade for Postoperative Analgesia in Mandibular Third Molar Surgery by a Perineural Addition of Dexamethasone to 0.5% Ropivacaine: A Randomized Comparison Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subject Selection
2.1.1. Study Design
2.1.2. Exclusion Criteria
2.2. Techniques of Injections of Local Anesthetics and Dexamethasone
2.3. Wisdom Tooth Surgery
2.4. Summary of Anesthesia and Analgesia Parameters with Defined Outcomes
2.5. Sample Size
2.6. Statistical Analysis
3. Results
4. Discussion
Strengths and Weaknesses of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Rop + Dex (Group I) N = 15 | Rop (Group II) N = 15 | Bup (Group III) N = 15 | ||||
---|---|---|---|---|---|---|
Age | 29.07 ± 7.40 | 24.53 ± 6.22 | 27.58 ± 10.32 | |||
95% CI of mean age | 24.97–33.16 | 21.09–27.98 | 21.86–33.29 | |||
Sex | ||||||
Male | 7 | 46.7 (%) | 3 | 20.0 (%) | 5 | 33.3 (%) |
Female | 8 | 53.3 (%) | 12 | 80.0 (%) | 10 | 66.7 (%) |
Ropivacaine + Dex N = 15 | Ropivacaine N = 15 | Bupivacaine N = 15 | p1 Values | |
---|---|---|---|---|
Primary local anesthesia outcomes | ||||
Duration of anesthesia (min) | 549.73 ± 224.56 b | 277.0 ± 61.52 | 316.47 ± 151.88 a | 0.001 |
Secondary local anesthesia outcomes | ||||
Onset time of anesthesia (min) | 4.13 ± 1.30 | 5.40 ± 2.10 | 4.47 ± 1.46 | 0.289 |
Success of local anesthesia in absolute terms #/%, with additional anesthesia #/% | 14 (93.4%) 1 (6.66%) | 10 (66.7%) 5 (33.33%) | 9 (60%) 6 (40%) | 0.034 2 |
Amount of anesthesia per patient (mL) | 4.13 | 4.66 | 4.8 | 0.097 |
The # of patients used analgesics #/% | 10 (66.7%) | 15 (100%/0%) | 13 (86.7%) | 0.052 |
NRS of pain when the first anlgesics used | 3.70 ± 0.68 | 4.93 ± 0.96 | 4.50 ± 0.76 | 0.004 |
Duration of analgesia when analgesics used for the first time (min) | 654.9 ± 198.4 b | 345.4 ± 88.0 | 413.7 ± 152.3 | 0.001 |
# of analgesics during 24 h postoeratively | 1.90 ± 0.57 b | 2.80 ± 0.86 | 2.36 ± 0.84 | 0.027 |
Dizziness #/% | 1 (2.22%) | 0 (0.0%) | 1 (2.22%) | 1.000 3 |
Drowiness #/% | 0 (0.0%) | 0 (0.0%) | 1 (2.22%) | 1.000 3 |
Haematoma #/% | 0 (0.0%) | 1 (2.22%) | 1 (2.22%) | 1.000 3 |
Positive aspiration #/% | 1 (2.22%) | 0 (0.0%) | 0 (0.0%) | 1.000 3 |
Transient paresthesia of n.lingualis #/% | 0 (0.0%) | 0 (0.0%) | 1 (2.22%) | 1.000 3 |
Administered Local Anesthesia Solutions | Achieved Mark | Mean Quality of Achieved Anesthesia | p Value 1 | |||||||
---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |||
GROUP I 0.5% Ropivacaine and 4 mg Dex | 9 | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 1.47 ± 0.38 | 0.037 |
GROUP II Plain 0.5% Ropivacaine | 3 | 7 | 2 | 2 | 1 | 0 | 0 | 0 | 2.40 ± 1.31 a | |
GROUP III 0.5% Bupivacaine | 4 | 5 | 4 | 2 | 0 | 0 | 0 | 0 | 2.27 ± 1.00 a |
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Stojanović, S.; Burić, N.; Tijanić, M.; Todorović, K.; Burić, K.; Burić, N.; Jovanović, M.; Bajagić, V. The Assessment of Prolonged Inferior Alveolar Nerve Blockade for Postoperative Analgesia in Mandibular Third Molar Surgery by a Perineural Addition of Dexamethasone to 0.5% Ropivacaine: A Randomized Comparison Study. Int. J. Environ. Res. Public Health 2022, 19, 1324. https://doi.org/10.3390/ijerph19031324
Stojanović S, Burić N, Tijanić M, Todorović K, Burić K, Burić N, Jovanović M, Bajagić V. The Assessment of Prolonged Inferior Alveolar Nerve Blockade for Postoperative Analgesia in Mandibular Third Molar Surgery by a Perineural Addition of Dexamethasone to 0.5% Ropivacaine: A Randomized Comparison Study. International Journal of Environmental Research and Public Health. 2022; 19(3):1324. https://doi.org/10.3390/ijerph19031324
Chicago/Turabian StyleStojanović, Simona, Nikola Burić, Milos Tijanić, Kosta Todorović, Kristina Burić, Nina Burić, Marija Jovanović, and Vukadin Bajagić. 2022. "The Assessment of Prolonged Inferior Alveolar Nerve Blockade for Postoperative Analgesia in Mandibular Third Molar Surgery by a Perineural Addition of Dexamethasone to 0.5% Ropivacaine: A Randomized Comparison Study" International Journal of Environmental Research and Public Health 19, no. 3: 1324. https://doi.org/10.3390/ijerph19031324