Implementation and Effectiveness of a Pharmacotherapeutic Follow-Up Service for People with Tuberculosis in Primary Healthcare
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Study Location and Healthcare System
2.3. Pharmacotherapy Follow-Up Service for People with Tuberculosis
2.4. Data Source and Collection
2.5. Assessment of Implementation of the Pharmacotherapy Follow-Up Service
2.6. Assessment of Effectiveness of the Pharmacotherapy Follow-Up Service
3. Results
3.1. Assessment of Effectiveness of the Pharmacotherapy Follow-Up Service
3.2. Assessment of Effectiveness of the Pharmacotherapy Follow-Up Service
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Included in the PFU Service | Not Included in the PFU Service | p-Value |
---|---|---|---|
(N = 721) | (N = 355) | ||
Sex—N (%) | |||
Female | 258 (35.9) | 115 (32.5) | 0.265 * |
Male | 460 (64.1) | 239 (67.5) | |
Age—Median (interquartile range) | 45 (26) | 43 (23) | 0.880 ** |
Race—N (%) | |||
White | 207 (30.0) | 113 (35.2) | 0.076 * |
Yellow | 2 (0.3) | 1 (0.3) | |
Brown | 360 (52.1) | 145 (45.2) | |
Black | 122 (17.6) | 60 (18.7) | |
Native | 0 (0.0) | 2 (0.6) | |
Number of medications used—Median (interquartile range) | 2 (5) | 1 (4) | 0.0001 ** |
Dropout risk—N (%) # | |||
Low | 352 (48.8) | 157 (45.0) | 0.239 * |
High | 369 (51.2) | 192 (55.0) | |
Clinical risk—N (%) # | |||
A | 608 (84.3) | 302 (86.0) | 0.418 * |
B | 106 (14.7) | 48 (13.7) | |
C | 7 (1.0) | 1 (0.3) | |
D | 0 | 0 | |
Directly Observed Treatment—N (%) | |||
No | 322 (44.9) | 62 (40.0) | 0.258 * |
Yes | 394 (55.1) | 93 (60.0) | |
Adverse Drug Reaction to Antituberculosis Drug—N (%) | |||
None | 439 (60.9) | N/A | N/A |
Mild | 257 (35.6) | N/A | N/A |
Severe | 25 (3.5) | N/A | N/A |
Pharmaceutical Prescription—N (%) | |||
Yes | 31 (4.3) | N/A | N/A |
No | 690 (95.7) | N/A | N/A |
Cure | Included in PFU Service | Not Included in PFU Service | HR (95%CI; p-Value) * | HR (95%CI; p-Value) ** |
---|---|---|---|---|
(N = 721) | (N = 355) | |||
Yes | 652 (90.43) | 261 (73.52) | 2.77 (2.08–3.67; <0.001) | 2.71 (2.04–3.61; <0.001) |
No | 69 (9.57) | 94 (26.48) |
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Lara-Júnior, C.R.; Ahouagi, A.E.d.O.; Pinto, I.V.L.; Braga, D.G.; Andrade, T.R.; Ramalho-de-Oliveira, D.; Nascimento, M.M.G.d. Implementation and Effectiveness of a Pharmacotherapeutic Follow-Up Service for People with Tuberculosis in Primary Healthcare. Int. J. Environ. Res. Public Health 2022, 19, 14552. https://doi.org/10.3390/ijerph192114552
Lara-Júnior CR, Ahouagi AEdO, Pinto IVL, Braga DG, Andrade TR, Ramalho-de-Oliveira D, Nascimento MMGd. Implementation and Effectiveness of a Pharmacotherapeutic Follow-Up Service for People with Tuberculosis in Primary Healthcare. International Journal of Environmental Research and Public Health. 2022; 19(21):14552. https://doi.org/10.3390/ijerph192114552
Chicago/Turabian StyleLara-Júnior, Célio Rezende, Ana Emília de Oliveira Ahouagi, Isabela Vaz Leite Pinto, Debora Gontijo Braga, Thiago Rabelo Andrade, Djenane Ramalho-de-Oliveira, and Mariana Martins Gonzaga do Nascimento. 2022. "Implementation and Effectiveness of a Pharmacotherapeutic Follow-Up Service for People with Tuberculosis in Primary Healthcare" International Journal of Environmental Research and Public Health 19, no. 21: 14552. https://doi.org/10.3390/ijerph192114552