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Volume 19
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10.3390/ijerph191811327
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Article

The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan

by
De-Kai Syu
1,
Shu-Hua Hsu
2,
Ping-Chun Yeh
1,
Tsung-Lin Lee
1,
Yu-Feng Kuo
1,
Yen-Chun Huang
3,4,
Ching-Chuan Jiang
1,* and
Mingchih Chen
3,4,*
1
Department of Orthopedics, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No. 69, Guizi Rd., Taishan Dist., New Taipei City 24352, Taiwan
2
Department of Family Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No. 69, Guizi Rd., Taishan Dist., New Taipei City 24352, Taiwan
3
Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City 242062, Taiwan
4
Artificial Intelligence Development Center, Fu Jen Catholic University, No. 510, Zhongzheng Rd., Xin-Zhuang Dist., New Taipei City 242062, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2022, 19(18), 11327; https://doi.org/10.3390/ijerph191811327
Submission received: 18 July 2022 / Revised: 5 September 2022 / Accepted: 7 September 2022 / Published: 9 September 2022
(This article belongs to the Special Issue Vascular Disease and Health)
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Abstract

Background: There are several possible links that have been used to claim that osteoporosis and peripheral artery disease (PAD) are associated; however, the solid evidence is not sufficient. This study aimed to use the Taiwan National Health Insurance Research Database (NHIRD) to determine if osteoporosis is associated with peripheral artery disease (PAD). Method: NHIRD records from 23 million patients were collected to recruit two matched cohort groups: 64,562 patients with and 64,562 patients without osteoporosis. To compare the crude hazard ratio (HR) and the incidence rate ratio between the two cohort groups for PAD, the Cox model was used. Result: With an adjusted HR of 1.18 (95% CI, 1.08–1.29), the osteoporosis cohort group had a significantly greater risk for PAD than the group without osteoporosis. The cumulative incidence of PAD in the cohort group was also statistically higher than it was in the group without osteoporosis (1.71% and 1.39%; p ≤ 0.0001, log-rank) over the 10-year follow-up period. In addition, the osteoporotic patients with ischemic stroke, chronic obstructive pulmonary disease (COPD), and congestive heart failure (CHF) had a significantly increased risk of PAD based on subgroup analysis. Conclusions: There was a positive association between osteoporosis and the development of PAD, as patients with osteoporosis had an increased incidence of PAD over time.
Keywords: peripheral arterial disease; osteoporosis; National Health Insurance Research Database; Taiwan peripheral arterial disease; osteoporosis; National Health Insurance Research Database; Taiwan

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MDPI and ACS Style

Syu, D.-K.; Hsu, S.-H.; Yeh, P.-C.; Lee, T.-L.; Kuo, Y.-F.; Huang, Y.-C.; Jiang, C.-C.; Chen, M. The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan. Int. J. Environ. Res. Public Health 2022, 19, 11327. https://doi.org/10.3390/ijerph191811327

AMA Style

Syu D-K, Hsu S-H, Yeh P-C, Lee T-L, Kuo Y-F, Huang Y-C, Jiang C-C, Chen M. The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan. International Journal of Environmental Research and Public Health. 2022; 19(18):11327. https://doi.org/10.3390/ijerph191811327

Chicago/Turabian Style

Syu, De-Kai, Shu-Hua Hsu, Ping-Chun Yeh, Tsung-Lin Lee, Yu-Feng Kuo, Yen-Chun Huang, Ching-Chuan Jiang, and Mingchih Chen. 2022. "The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan" International Journal of Environmental Research and Public Health 19, no. 18: 11327. https://doi.org/10.3390/ijerph191811327

APA Style

Syu, D.-K., Hsu, S.-H., Yeh, P.-C., Lee, T.-L., Kuo, Y.-F., Huang, Y.-C., Jiang, C.-C., & Chen, M. (2022). The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan. International Journal of Environmental Research and Public Health, 19(18), 11327. https://doi.org/10.3390/ijerph191811327

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