Next Article in Journal
Efficacy of Exercise on Muscle Function and Physical Performance in Older Adults with Sarcopenia: An Updated Systematic Review and Meta-Analysis
Previous Article in Journal
Effects of Blended Learning Program for Cyber Sexual Harassment Prevention among Female High School Students in Bangkok, Thailand
 
 
Article

Metformin and the Development of Asthma in Patients with Type 2 Diabetes

1
Dr. Yen’s Clinic, Taoyuan 33354, Taiwan
2
Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 35053, Taiwan
3
Department of Health Services Administration, China Medical University, Taichung 40402, Taiwan
4
Department of Family Medicine, Min-Sheng General Hospital, Taoyuan 33044, Taiwan
5
Management Office for Health Data, China Medical University Hospital, Taichung 40459, Taiwan
6
College of Medicine, China Medical University, Taichung 40201, Taiwan
7
Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan
8
Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
9
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
10
Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan
11
Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei 11221, Taiwan
12
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2022, 19(13), 8211; https://doi.org/10.3390/ijerph19138211
Received: 31 May 2022 / Revised: 2 July 2022 / Accepted: 3 July 2022 / Published: 5 July 2022
We conducted this study to compare the risks of asthma development and exacerbation between metformin users and nonusers. Overall, 57,743 propensity score-matched metformin users and nonusers were identified from Taiwan’s National Health Insurance Research Database between 1 January 2000, and 31 December 2017. We used the Cox proportional hazards model with robust standard error estimates to compare the risks of asthma onset, exacerbation, and hospitalization for asthma in participants with type 2 diabetes (T2D). Compared with metformin nonuse, the aHRs (95% CI) for metformin use in asthma development, exacerbation, and hospitalization for asthma were 1.13 (1.06–1.2), 1.62 (1.35–1.95), and 1.5 (1.22–1.85), respectively. The cumulative incidences of asthma development, exacerbation, and hospitalization for asthma were significantly higher in metformin users than nonusers (p < 0.001). A longer cumulative duration of metformin use for more than 728 days was associated with significantly higher risks of outcomes than metformin nonuse. Our study demonstrated that metformin users showed significantly higher risks of asthma development, exacerbation, and hospitalization for asthma than metformin nonusers. Moreover, metformin use for more than 728 days was associated with higher risks of outcomes. A randomized control study is warranted to verify our results. View Full-Text
Keywords: type 2 diabetes; metformin; asthma; exacerbation; hospitalization type 2 diabetes; metformin; asthma; exacerbation; hospitalization
Show Figures

Figure 1

MDPI and ACS Style

Yen, F.-S.; Hsu, C.-C.; Shih, Y.-H.; Pan, W.-L.; Wei, J.C.-C.; Hwu, C.-M. Metformin and the Development of Asthma in Patients with Type 2 Diabetes. Int. J. Environ. Res. Public Health 2022, 19, 8211. https://doi.org/10.3390/ijerph19138211

AMA Style

Yen F-S, Hsu C-C, Shih Y-H, Pan W-L, Wei JC-C, Hwu C-M. Metformin and the Development of Asthma in Patients with Type 2 Diabetes. International Journal of Environmental Research and Public Health. 2022; 19(13):8211. https://doi.org/10.3390/ijerph19138211

Chicago/Turabian Style

Yen, Fu-Shun, Chih-Cheng Hsu, Ying-Hsiu Shih, Wei-Lin Pan, James Cheng-Chung Wei, and Chii-Min Hwu. 2022. "Metformin and the Development of Asthma in Patients with Type 2 Diabetes" International Journal of Environmental Research and Public Health 19, no. 13: 8211. https://doi.org/10.3390/ijerph19138211

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop