Predictive Accuracy of Singleton Versus Customized Twin Growth Chart for Adverse Perinatal Outcome: A Cohort Study
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- The Investigation and Management of the Small–for–Gestational–Age Fetus. Available online: https://www.rcog.org.uk/globalassets/documents/guidelines/gtg_31.pdf (accessed on 1 December 2014).
- Clausson, B.; Gardosi, J.; Francis, A.; Cnattingius, S. Perinatal outcome in SGA births defined by customised versus population-based birthweight standards. BJOG 2001, 108, 830–834. [Google Scholar] [PubMed]
- Figueras, F.; Figueras, J.; Meler, E.; Eixarch, E.; Coll, O.; Gratacos, E.; Gardosi, J.; Carbonell, X. Customised birthweight standards accurately predict perinatal morbidity. Arch. Dis. Child. Fetal. Neonatal. Ed. 2007, 92, F277–F280. [Google Scholar] [CrossRef]
- Figueras, F.; Eixarch, E.; Gratacos, E.; Gardosi, J. Predictiveness of antenatal umbilical artery Doppler for adverse pregnancy outcome in small-for-gestational-age babies according to customised birthweight centiles: Population-based study. BJOG 2008, 115, 590–594. [Google Scholar] [CrossRef] [PubMed]
- Figueras, F.; Eixarch, E.; Meler, E.; Iraola, A.; Figueras, J.; Puerto, B.; Gratacos, E. Small-for-gestational-age fetuses with normal umbilical artery Doppler have suboptimal perinatal and neurodevelopmental outcome. Eur. J. Obstet. Gynecol. Reprod. Biol. 2008, 136, 34–38. [Google Scholar] [CrossRef]
- Blickstein, I. Is it normal for multiples to be smaller than singletons? Best Pract. Res. Clin. Obstet. Gynaecol. 2004, 18, 613–623. [Google Scholar] [CrossRef] [PubMed]
- Stirrup, O.T.; Khalil, A.; D’Antonio, F.; Thilaganathan, B. STORK: Patterns of second- and third-trimester growth and discordance in twin pregnancy: Analysis of the Southwest Thames Obstetric Research Collaborative (STORK) Multiple Pregnancy Cohort. Fetal. Diagn. Ther. 2017, 41, 100–107. [Google Scholar] [CrossRef]
- Papageorghiou, A.T.; Bakoulas, V.; Sebire, N.J.; Nicolaides, K.H. Intrauterine growth in multiple pregnancies in relation to fetal number, chorionicity and gestational age. Ultrasound Obstet. Gynecol. 2008, 32, 890–893. [Google Scholar] [CrossRef]
- Torres, X.; Bennasar, M.; Eixarch, E.; Rueda, C.; Goncé, A.; Muñoz, M.; Marimón, E.; Martínez, J.M.; Gratacós, E.; Figueras, F. Gender-Specific Antenatal Growth Reference Charts in Monochorionic Twins. Fetal. Diagn. Ther. 2018, 44, 202–209. [Google Scholar] [CrossRef]
- Ananth, C.V.; Vintzileos, A.M.; Shen-Schwarz, S.; Smulian, J.C.; Lai, Y.L. Standards of birth weight in twin gestations stratified by placental chorionicity. Obstet. Gynecol. 1998, 91, 917–924. [Google Scholar]
- Odibo, A.O.; Cahill, A.G.; Goetzinger, K.R.; Harper, L.M.; Tuuli, M.G.; Macones, G.A. Customized growth charts for twin gestations to optimize identification of small-for-gestational age fetuses at risk of intrauterine fetal death. Ultrasound Obstet. Gynecol. 2013, 41, 637–642. [Google Scholar] [CrossRef]
- Ghi, T.; Prefumo, F.; Fichera, A.; Lanna, M.; Periti, E.; Persico, N.; Viora, E.; Rizzo, G.; Società Italiana di Ecografia Ostetrica e Ginecologica Working Group on Fetal Biometric Charts. Development of customized fetal growth charts in twins. Am. J. Obstet. Gynecol 2017, 216, 514.e1–514.e17. [Google Scholar] [CrossRef]
- Hadlock, F.P.; Harrist, R.B.; Sharman, R.S.; Deter, R.L.; Park, S.K. Estimation of fetal weight with the use of head, body, and femur measurements—A prospective study. Am. J. Obstet. Gynecol. 1985, 151, 333–337. [Google Scholar] [CrossRef]
- Ghi, T.; Cariello, L.; Rizzo, L.; Ferrazzi, E.; Periti, E.; Prefumo, F.; Stampalija, T.; Viora, E.; Verrotti, C.; Rizzo, G.; et al. Customized Fetal Growth Charts for Parents’ Characteristics, Race, and Parity by Quantile Regression Analysis: A Cross-sectional Multicenter Italian Study. J. Ultrasound Med. 2016, 35, 83–92. [Google Scholar] [CrossRef]
- Sarzyńska-Nowacka, U.; Kosińska-Kaczyńska, K. Fetal growth charts for twin gestation—On the horns of a dilemma. In Proceedings of the XXXIII Congress of Polish Society of Obstetricians and Gynecologists, Warsaw, Poland, 13–15 September 2018. [Google Scholar]
- Blickstein, I. Normal and abnormal growth of multiples. Sem. Neonat. 2002, 7, 177–185. [Google Scholar] [CrossRef] [PubMed]
- Mendez-Figueroa, H.; Truong, V.T.T.; Pedroza, C.; Chauhan, S.P. Growth among Twins: Use of Singleton versus Twin-Specific Growth Nomograms. Am. J. Perinatol. 2018, 35, 184–191. [Google Scholar] [CrossRef]
- Stirrup, O.T.; Khalil, A.; D’Antonio, F.; Thilaganathan, B. Southwest Thames Obstetric Research Collaborative (STORK). Fetal growth reference ranges in twin pregnancy: Analysis of the Southwest Thames Obstetric Research Collaborative (STORK) multiple pregnancy cohort. Ultrasound Obstet. Gynecol. 2015, 45, 301–307. [Google Scholar] [CrossRef]
- Bricelj, K.; Blickstein, I.; Bržan-Šimenc, G.; Janša, V.; Lučovnik, M.; Verdenik, I.; Trojner-Bregar, A.; Tul, N. Growth curves for twins in Slovenia. J. Matern. Fetal Neonatal Med. 2017, 30, 479–481. [Google Scholar] [CrossRef] [PubMed]
- Kibel, M.; Kahn, M.; Sherman, C.; Kingdom, J.; Zaltz, A.; Barrett, J.; Melamed, N. Placental abnormalities differ between small for gestational age fetuses in dichorionic twin and singleton pregnancies. Placenta 2017, 60, 28–35. [Google Scholar] [CrossRef]
- Grantz, K.L.; Grewal, J.; Albert, P.S.; Wapner, R.; D’Alton, M.E.; Sciscione, A.; Grobman, W.A.; Wing, D.A.; Owen, J.; Newman, R.B.; et al. Dichorionic twin trajectories: The NICHD Fetal Growth Studies. Am. J. Obstet. Gynecol. 2016, 215, 221.e1–221.e16. [Google Scholar] [CrossRef]
- Gielen, M.; Lindsey, P.J.; Derom, C.; Loos, R.J.; Souren, N.Y.; Paulussen, A.D.; Zeegers, M.P.; Derom, R.; Vlietinck, R.; Nijhuis, J.G. Twin-specific intrauterine ‘growth’ charts based on cross-sectional birthweight data. Twin Res. Hum. Genet. 2008, 11, 224–235. [Google Scholar] [CrossRef]
- Kalafat, E.; Sebghati, M.; Thilaganathan, B.; Khalil, A.; Southwest Thames Obstetric Research Collaborative (STORK). Predictive accuracy of Southwest Thames Obstetric Research Collaborative (STORK) chorionicity-specific twin growth charts for stillbirth: A validation study. Ultrasound Obstet. Gynecol. 2019, 53, 193–199. [Google Scholar] [CrossRef] [PubMed]
- Cordiez, S.; Deruelle, P.; Drumez, E.; Bodart, S.; Subtil, D.; Houfflin-Debarge, V.; Garabedian, C. Impact of customized growth curves on screening for small for gestational age twins. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017, 215, 28–32. [Google Scholar] [CrossRef]
- Ego, A.; Subtil, D.; Grange, G.; Thiebaugeorges, O.; Senat, M.V.; Vayssiere, C.; Zeitlin, J. Customized versus population-based birth weight standards for identifying growth restricted infants: A French multicenter study. Am. J. Obstet. Gynecol. 2006, 194, 1042–1049. [Google Scholar] [CrossRef]
- Ego, A.; Prunet, C.; Lebreton, E.; Blondel, B.; Kaminski, M.; Goffinet, F.; Zeitlin, J. Courbes de croissance in utero ajustées et non ajustées adaptées à la population française. I—Méthodes de construction [Customized and non-customized French intrauterine growth curves. I—Methodology]. J. Gynecol. Obstet. Biol. Reprod. (Paris) 2016, 45, 155–164. [Google Scholar] [CrossRef]
- Puccio, G.; Giuffré, M.; Piccione, M.; Piro, E.; Malerba, V.; Corsello, G. Intrauterine growth pattern and birthweight discordance in twin pregnancies: A retrospective study. Ital. J. Pediatr. 2014, 40, 43. [Google Scholar] [CrossRef]
- Allaf, M.B.; Vintzileos, A.M.; Chavez, M.R.; Wax, J.A.; Ravangard, S.F.; Figueroa, R.; Borgida, A.; Shamshirsaz, A.; Markenson, G.; Davis, S.; et al. First-trimester sonographic prediction of obstetric and neonatal outcomes in monochorionic diamniotic twin pregnancies. J. Ultrasound Med. 2014, 33, 135–140. [Google Scholar] [CrossRef] [PubMed]
- Allaf, M.B.; Campbell, W.A.; Vintzileos, A.M.; Haeri, S.; Javadian, P.; Shamshirsaz, A.A.; Ogburn, P.; Figueroa, R.; Wax, J.; Markenson, G.; et al. Does early second-trimester sonography predict adverse perinatal outcomes in monochorionic diamniotic twin pregnancies? J. Ultrasound Med. 2014, 33, 1573–1578. [Google Scholar] [CrossRef]
Included | Excluded | ||
---|---|---|---|
Total N = 322 | Total (%) | Total N = 184 | |
Ethnicity | |||
| 312 | 96.9 | 182 |
| 10 | 3.1 | 2 |
Maternal age (years) | |||
| 1 | 0.3 | 2 |
| 259 | 80.4 | 137 |
| 62 | 19.3 | 34 |
Primiparity | 221 | 68.6 | 83 |
Parity Ϯ | 1.39 | 0.72 | 1.39 |
Chorionicity | |||
| 247 | 76.7 | 12 |
| 75 | 23.3 | 19 |
Smoking during pregnancy | 17 | 5.3 | |
ART | 109 | 33.9 | |
Diabetes mellitus (pre- and gestational) | 58 | 18.0 | |
Hypertensive disease of pregnancy | 99 | 30.7 | |
Intrahepatic cholestasis of pregnancy | 12 | 3.7 | |
Gestational age at delivery (weeks) | |||
| 2 | 0.6 | |
| 24 | 7.5 | |
| 187 | 58.1 | |
| 109 | 33.9 | |
Caesarean delivery | 210 | 65.2 | |
Vaginal delivery | 112 | 34.8 |
Singleton Normogram | Twin Normogram | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
SGA (N = 131) | AGA (N = 481) | LGA (N = 32) | RR SGA vs. AGA | RR (95% CI) | SGA (N = 63) | AGA (N = 518) | LGA (N = 63) | RR SGA vs. AGA | RR (95% CI) | |
Composite neonatal morbidity | 47 | 94 | 4 | 31 | 102 | 11 | ||||
Apgar score < 8 at 5 min | 14 | 12 | 1 | 9 | 16 | 2 | ||||
CPAP | 23 | 63 | 3 | 1.9 | 1.2–2.9 | 16 | 66 | 7 | 2.5 | 1.5–4.3 |
Mechanical ventilation | 19 | 28 | 1 | 4.3 | 1.9–9.5 | 12 | 33 | 3 | 4.6 | 2.0–11.0 |
NICU admission | 45 | 94 | 4 | 2.5 | 1.4–4.6 | 31 | 102 | 10 | 3.1 | 1.6–6.3 |
IVH (grade 3 or 4) | 1 | 3 | 0 | 1.3 | 0.8–2.3 | 1 | 3 | 0 | 2.0 | 1.1–3.7 |
NEC | 2 | 0 | 0 | 2.5 | 1.3–4.6 | 2 | 0 | 0 | 3.0 | 1.5–6.1 |
Sepsis | 3 | 2 | 0 | 2.0 | 1.2–3.4 | 3 | 2 | 0 | 2.5 | 1.3–4.6 |
Pneumonia/inborn infection | 28 | 50 | 2 | 1.2 | 0.1–11.9 | 19 | 56 | 5 | 2.7 | 0.3–26.8 |
Neonatal death | 5 | 5 | 0 | 4 | 4 | 2 |
Singleton Normogram | Total | Females | Males | MCDA | DCDA |
---|---|---|---|---|---|
Sensitivity | 32.9% | 35.5% | 28.9% | 48.9% | 25.5% |
Specificity | 83.2% | 82.3% | 87.4% | 77.1% | 84.8% |
Positive predictive value | 35.9% | 34.9% | 44.0% | 47.8% | 29.4% |
Negative predictive value | 81.3% | 82.6% | 78.3% | 77.9% | 82.2% |
p-value (for this type of test) | 0.17 | 0.18 | 0.13 | 0.23 | 0.15 |
Twin Normogram | |||||
Sensitivity | 21.7% | 17.7% | 22.1% | 33.3% | 16.3% |
Specificity | 93.6% | 94.4% | 96.3% | 88.6% | 94.9% |
Positive predictive value | 49.2% | 45.8% | 68.0% | 55.6% | 44.4% |
Negative predictive value | 80.7% | 81.0% | 77.6% | 75.6% | 82.1% |
p-value (for this type of test) | 0.06 | 0.06 | 0.04 | 0.11 | 0.05 |
Singleton Normogram | Twin Normogram | Hadlock [13] | Customised Ego [25] | EPOPé MO [26] | EPOPé M1 [26] | |
---|---|---|---|---|---|---|
Sensitivity | 32.9% | 21.7% | 67.3% | 63.0% | 59.9% | 57.4% |
Specificity | 83.2% | 93.6% | 80.0% | 82.3% | 83.5% | 83.2% |
PPV | 35.9% | 42.9% | 63.7% | 65.0% | 65.5% | 64.1% |
NPV | 81.3% | 80.7% | 82.4% | 80.9% | 79.9% | 78.9% |
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Nowacka, U.; Kosińska-Kaczyńska, K.; Krajewski, P.; Saletra-Bielińska, A.; Walasik, I.; Szymusik, I. Predictive Accuracy of Singleton Versus Customized Twin Growth Chart for Adverse Perinatal Outcome: A Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 2016. https://doi.org/10.3390/ijerph18042016
Nowacka U, Kosińska-Kaczyńska K, Krajewski P, Saletra-Bielińska A, Walasik I, Szymusik I. Predictive Accuracy of Singleton Versus Customized Twin Growth Chart for Adverse Perinatal Outcome: A Cohort Study. International Journal of Environmental Research and Public Health. 2021; 18(4):2016. https://doi.org/10.3390/ijerph18042016
Chicago/Turabian StyleNowacka, Urszula, Katarzyna Kosińska-Kaczyńska, Paweł Krajewski, Aleksandra Saletra-Bielińska, Izabela Walasik, and Iwona Szymusik. 2021. "Predictive Accuracy of Singleton Versus Customized Twin Growth Chart for Adverse Perinatal Outcome: A Cohort Study" International Journal of Environmental Research and Public Health 18, no. 4: 2016. https://doi.org/10.3390/ijerph18042016
APA StyleNowacka, U., Kosińska-Kaczyńska, K., Krajewski, P., Saletra-Bielińska, A., Walasik, I., & Szymusik, I. (2021). Predictive Accuracy of Singleton Versus Customized Twin Growth Chart for Adverse Perinatal Outcome: A Cohort Study. International Journal of Environmental Research and Public Health, 18(4), 2016. https://doi.org/10.3390/ijerph18042016