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Article

The GGLEAM Study: Understanding Glaucoma in the Ohio Amish

1
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
2
Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA
3
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
4
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5
Ohio Eye Associates, Mansfield, OH 44906, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(4), 1551; https://doi.org/10.3390/ijerph18041551
Received: 23 December 2020 / Revised: 2 February 2021 / Accepted: 3 February 2021 / Published: 6 February 2021
(This article belongs to the Special Issue Genetic Epidemiology: The State-of-the-Art and Future Perspectives)
Glaucoma leads to millions of cases of visual impairment and blindness around the world. Its susceptibility is shaped by both environmental and genetic risk factors. Although over 120 risk loci have been identified for glaucoma, a large portion of its heritability is still unexplained. Here we describe the foundation of the Genetics of GLaucoma Evaluation in the AMish (GGLEAM) study to investigate the genetic architecture of glaucoma in the Ohio Amish, which exhibits lower genetic and environmental heterogeneity compared to the general population. To date, we have enrolled 81 Amish individuals in our study from Holmes County, Ohio. As a part of our enrollment process, 62 GGLEAM study participants (42 glaucoma-affected and 20 unaffected individuals) received comprehensive eye examinations and glaucoma evaluations. Using the data from the Anabaptist Genealogy Database, we found that 80 of the GGLEAM study participants were related to one another through a large, multigenerational pedigree containing 1586 people. We plan to integrate the health and kinship data obtained for the GGLEAM study to interrogate glaucoma genetics and pathophysiology in this unique population. View Full-Text
Keywords: glaucoma; vision; endophenotype; family history; founder population; Amish glaucoma; vision; endophenotype; family history; founder population; Amish
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MDPI and ACS Style

Waksmunski, A.R.; Song, Y.E.; Kinzy, T.G.; Laux, R.A.; Sewell, J.; Fuzzell, D.; Fuzzell, S.; Miller, S.; Wiggs, J.L.; Pasquale, L.R.; Skarie, J.M.; Haines, J.L.; Cooke Bailey, J.N. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish. Int. J. Environ. Res. Public Health 2021, 18, 1551. https://doi.org/10.3390/ijerph18041551

AMA Style

Waksmunski AR, Song YE, Kinzy TG, Laux RA, Sewell J, Fuzzell D, Fuzzell S, Miller S, Wiggs JL, Pasquale LR, Skarie JM, Haines JL, Cooke Bailey JN. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish. International Journal of Environmental Research and Public Health. 2021; 18(4):1551. https://doi.org/10.3390/ijerph18041551

Chicago/Turabian Style

Waksmunski, Andrea R., Yeunjoo E. Song, Tyler G. Kinzy, Reneé A. Laux, Jane Sewell, Denise Fuzzell, Sarada Fuzzell, Sherri Miller, Janey L. Wiggs, Louis R. Pasquale, Jonathan M. Skarie, Jonathan L. Haines, and Jessica N. Cooke Bailey. 2021. "The GGLEAM Study: Understanding Glaucoma in the Ohio Amish" International Journal of Environmental Research and Public Health 18, no. 4: 1551. https://doi.org/10.3390/ijerph18041551

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