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Article

Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy
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Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy
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PhD Degree Program in Pharmacological Sciences, Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy
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Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
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Department of Biomedical Sciences, Dental Sciences, & Morpho-Functional Imaging, Polyclinic Hospital University, 98124 Messina, Italy
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International Society of Doctors for Environment, 82100 Benevento, Italy
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Italian Association for Metals and Biocompatibility Research—A.I.R.M.E.B., 20122 Milan, Italy
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Department of Neuroscience, Imaging and Clinical Science, ‘G. d’Annunzio’ University of Chieti-Pescara, 66100 Chieti, Italy
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Institute of Mountain Emergency Medicine, Eurac Research, 39100 Bolzano, Italy
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ITER Center for Balance and Rehabilitation Research (ICBRR), 02032 Rome, Italy
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Department of Internal Medicine, Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, 00189 Rome, Italy
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Department of MeSVA, University of L’Aquila, 67100 L’Aquila, Italy
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Natrail Tagesklinik, 81925 Munchen, Germany
*
Author to whom correspondence should be addressed.
Patient with Multiple Chemical Sensitivity (MCS. The patient wanted to remain anonymous, so we decided to use a pseudonym).
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(21), 11294; https://doi.org/10.3390/ijerph182111294
Received: 25 August 2021 / Revised: 15 October 2021 / Accepted: 19 October 2021 / Published: 27 October 2021
Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM). View Full-Text
Keywords: multiple chemical sensitivity (MCS); chemical intolerance; threshold limit value; environmental exposure; neurogenic inflammation multiple chemical sensitivity (MCS); chemical intolerance; threshold limit value; environmental exposure; neurogenic inflammation
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MDPI and ACS Style

Damiani, G.; Alessandrini, M.; Caccamo, D.; Cormano, A.; Guzzi, G.; Mazzatenta, A.; Micarelli, A.; Migliore, A.; Piroli, A.; Bianca, M.; Tapparo, O.; Pigatto, P.D.M. Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS). Int. J. Environ. Res. Public Health 2021, 18, 11294. https://doi.org/10.3390/ijerph182111294

AMA Style

Damiani G, Alessandrini M, Caccamo D, Cormano A, Guzzi G, Mazzatenta A, Micarelli A, Migliore A, Piroli A, Bianca M, Tapparo O, Pigatto PDM. Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS). International Journal of Environmental Research and Public Health. 2021; 18(21):11294. https://doi.org/10.3390/ijerph182111294

Chicago/Turabian Style

Damiani, Giovanni, Marco Alessandrini, Daniela Caccamo, Andrea Cormano, Gianpaolo Guzzi, Andrea Mazzatenta, Alessandro Micarelli, Alberto Migliore, Alba Piroli, Margherita Bianca, Ottaviano Tapparo, and Paolo D.M. Pigatto 2021. "Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)" International Journal of Environmental Research and Public Health 18, no. 21: 11294. https://doi.org/10.3390/ijerph182111294

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