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IJERPH
Volume 18
Issue 21
10.3390/ijerph182111045
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Article

Assessment of Oral Chemotherapy Nonadherence in Chronic Myeloid Leukemia Patients Using Brief Measures in Community Cancer Clinics: A Pilot Study

by
Terry C. Davis
1,*,
Connie L. Arnold
1,
Glenn Mills
1,
Glenn J. Lesser
2,
W. Mark Brown
3,
Richard Schulz
4,
Kathryn E. Weaver
5 and
Pamala A. Pawloski
6
1
Department of Medicine, Louisiana State University Health—Shreveport, Shreveport, LA 71130, USA
2
Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
3
Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
4
College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
5
Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA
6
Metro-Minnesota Community Oncology Research Consortium, St. Louis Park, MN 55416, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(21), 11045; https://doi.org/10.3390/ijerph182111045
Submission received: 9 September 2021 / Revised: 15 October 2021 / Accepted: 18 October 2021 / Published: 21 October 2021
(This article belongs to the Section Health Care Sciences & Services)
Versions Notes

Abstract

The purpose of this pilot study was to assess Chronic Myeloid Leukemia (CML) patients’ adherence to, beliefs about, and barriers to oral anticancer agents (OAC) using brief self-report measures in community-based cancer clinics. Patients completed a structured interview including a health literacy assessment, a Brief Medication Questionnaire, two single-item self-report adherence questions, and the Medications Adherence Reasons Scale. Of the 86 participants, 88.4% were white; 55.8% male; mean age, 58.7 years; and 22.1% had limited health literacy. Nonadherence (missing at least one dose in the last week) was reported by 18.6% of participants and associated (p < 0.003) with less-than-excellent perceived ability to take CML medications (16.3%). Black participants reported more difficulty taking CML medications than white participants (28.6% vs. 8.3%, p = 0.053). Among all participants, 43.0% reported their CML medicine was ineffective and 24.4% that taking CML pills was somewhat to very hard. The most common reasons for missing a dose were simply missed it (24.4%) and side effects (18.6%). Most patients perceived their ability to take CML medication was good to excellent, yet nearly one in five reported missing at least one dose in the last week. Brief, no-cost self-report assessments to screen CML patients’ OAC adherence, barriers, and beliefs could facilitate counseling in busy community cancer clinics.
Keywords: chronic myelogenous leukemia; antineoplastic agents; medication adherence; self-report; health literacy chronic myelogenous leukemia; antineoplastic agents; medication adherence; self-report; health literacy

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MDPI and ACS Style

Davis, T.C.; Arnold, C.L.; Mills, G.; Lesser, G.J.; Brown, W.M.; Schulz, R.; Weaver, K.E.; Pawloski, P.A. Assessment of Oral Chemotherapy Nonadherence in Chronic Myeloid Leukemia Patients Using Brief Measures in Community Cancer Clinics: A Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 11045. https://doi.org/10.3390/ijerph182111045

AMA Style

Davis TC, Arnold CL, Mills G, Lesser GJ, Brown WM, Schulz R, Weaver KE, Pawloski PA. Assessment of Oral Chemotherapy Nonadherence in Chronic Myeloid Leukemia Patients Using Brief Measures in Community Cancer Clinics: A Pilot Study. International Journal of Environmental Research and Public Health. 2021; 18(21):11045. https://doi.org/10.3390/ijerph182111045

Chicago/Turabian Style

Davis, Terry C., Connie L. Arnold, Glenn Mills, Glenn J. Lesser, W. Mark Brown, Richard Schulz, Kathryn E. Weaver, and Pamala A. Pawloski. 2021. "Assessment of Oral Chemotherapy Nonadherence in Chronic Myeloid Leukemia Patients Using Brief Measures in Community Cancer Clinics: A Pilot Study" International Journal of Environmental Research and Public Health 18, no. 21: 11045. https://doi.org/10.3390/ijerph182111045

APA Style

Davis, T. C., Arnold, C. L., Mills, G., Lesser, G. J., Brown, W. M., Schulz, R., Weaver, K. E., & Pawloski, P. A. (2021). Assessment of Oral Chemotherapy Nonadherence in Chronic Myeloid Leukemia Patients Using Brief Measures in Community Cancer Clinics: A Pilot Study. International Journal of Environmental Research and Public Health, 18(21), 11045. https://doi.org/10.3390/ijerph182111045

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