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An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS

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Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
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School of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka 10101, Zambia
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Department of Chemistry, College of Natural and Computational Science, University of Gondar, P.O. Box 196, Gondar 6200, Ethiopia
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Department of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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Water Research Group, School of Environmental Sciences and Development, North-West University, Private Bag X6001, Potchefstroom 2531, South Africa
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Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(2), 767; https://doi.org/10.3390/ijerph18020767
Received: 24 November 2020 / Revised: 12 January 2021 / Accepted: 13 January 2021 / Published: 18 January 2021
(This article belongs to the Section Environmental Health)
Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The crown accumulated much Pb-T than the root of the Sprague Dawley rat incisor. The levels of lead in blood (Pb-B) were positively correlated with the Pb-T in the crown and root incisors of the Sprague Dawley rats. As an application of the Pb-T crown results in experimental rats, we subsequently analyzed the Pb-T in the crown incisors of Pb-exposed wild rats (Rattus rattus) sampled from residential sites within varying distances from an abandoned lead–zinc mine. The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb–Zn mine. Furthermore, the Pb-T was strongly correlated (r = 0.85) with the Pb levels in the blood. Laser ablation ICP-MS Pb-T mappings revealed a homogenous distribution of Pb in the incisor with an increased intensity of Pb-T localized in the tip of the incisor crown bearing an enamel surface in both Sprague Dawley and R. rattus rats. These findings suggest that Pb-T in the crown incisor may be reflective of the rat’s environmental habitat, thus a possible indicator of Pb exposure. View Full-Text
Keywords: lead; incisor; biomarker; sentinel; wild rodent lead; incisor; biomarker; sentinel; wild rodent
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MDPI and ACS Style

Kataba, A.; Nakayama, S.M.M.; Nakata, H.; Toyomaki, H.; Yohannes, Y.B.; Yabe, J.; Muzandu, K.; Zyambo, G.; Kubota, A.; Matsukawa, T.; Yokoyama, K.; Ikenaka, Y.; Ishizuka, M. An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS. Int. J. Environ. Res. Public Health 2021, 18, 767. https://doi.org/10.3390/ijerph18020767

AMA Style

Kataba A, Nakayama SMM, Nakata H, Toyomaki H, Yohannes YB, Yabe J, Muzandu K, Zyambo G, Kubota A, Matsukawa T, Yokoyama K, Ikenaka Y, Ishizuka M. An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS. International Journal of Environmental Research and Public Health. 2021; 18(2):767. https://doi.org/10.3390/ijerph18020767

Chicago/Turabian Style

Kataba, Andrew, Shouta M. M. Nakayama, Hokuto Nakata, Haruya Toyomaki, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Golden Zyambo, Ayano Kubota, Takehisa Matsukawa, Kazuhito Yokoyama, Yoshinori Ikenaka, and Mayumi Ishizuka. 2021. "An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS" International Journal of Environmental Research and Public Health 18, no. 2: 767. https://doi.org/10.3390/ijerph18020767

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