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Article

Characterisation of Bacterial Isolates from Infected Post-Operative Patients in a Malaysian Tertiary Heart Care Centre

1
School of Health Science, International Medical University, Kuala Lumpur 57000, Malaysia
2
School of Medicine, International Medical University, Kuala Lumpur 57000, Malaysia
3
Institut Jantung Negara, Kuala Lumpur 50400, Malaysia
4
School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(18), 9828; https://doi.org/10.3390/ijerph18189828
Received: 17 August 2021 / Revised: 7 September 2021 / Accepted: 8 September 2021 / Published: 17 September 2021
Several bacterial species cause post-operative infections, which has been a critical health concern among hospital patients. Our study in this direction is a much-needed exploratory study that was carried out at the National Heart Institute (IJN) of Malaysia to examine the virulence properties of causative bacteria obtained from postoperative patients. The bacterial isolates and data were provided by the IJN. Antibiotic resistance gene patterns, and the ability to form biofilm were investigated for 127 isolates. Klebsiella pneumoniae (36.2%) was the most common isolate collected, which was followed by Pseudomonas aeruginosa (26%), Staphylococcus aureus (23.6%), Streptococcus spp. (8.7%) and Acinetobacter baumannii (5.5%). There were 49 isolates that showed the presence of multidrug resistance genes. The mecA gene was surprisingly found in methicillin-susceptible S. aureus (MSSA), which also carried the ermA gene from those erythromycin-susceptible strains. The phenotypic antibiotic resistance profiles varied greatly between isolates. Findings from the biofilm assay revealed that 44 of the 127 isolates demonstrated the ability to produce biofilms. Our findings provide insights into the possibility of some of these bacteria surviving under antibiotic stress, and some antibiotic resistance genes being silenced. View Full-Text
Keywords: postoperative patients; bacterial infection; ESBL genes postoperative patients; bacterial infection; ESBL genes
MDPI and ACS Style

Yong, Y.K.; Wen, N.C.M.; Yeo, G.E.C.; Chew, Z.X.; Chan, L.L.; Md Zain, N.Z.; Chellappan, D.K.; Liew, Y.K. Characterisation of Bacterial Isolates from Infected Post-Operative Patients in a Malaysian Tertiary Heart Care Centre. Int. J. Environ. Res. Public Health 2021, 18, 9828. https://doi.org/10.3390/ijerph18189828

AMA Style

Yong YK, Wen NCM, Yeo GEC, Chew ZX, Chan LL, Md Zain NZ, Chellappan DK, Liew YK. Characterisation of Bacterial Isolates from Infected Post-Operative Patients in a Malaysian Tertiary Heart Care Centre. International Journal of Environmental Research and Public Health. 2021; 18(18):9828. https://doi.org/10.3390/ijerph18189828

Chicago/Turabian Style

Yong, Yi K., Nicole C.M. Wen, Genieve E.C. Yeo, Zhi X. Chew, Li L. Chan, Noor Z. Md Zain, Dinesh K. Chellappan, and Yun K. Liew 2021. "Characterisation of Bacterial Isolates from Infected Post-Operative Patients in a Malaysian Tertiary Heart Care Centre" International Journal of Environmental Research and Public Health 18, no. 18: 9828. https://doi.org/10.3390/ijerph18189828

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