The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature
Abstract
:1. Introduction
2. Material and Methods
3. Results and Discussion
3.1. Preoperative Assessment
3.2. Surgical and Hormone Therapies
3.3. Differential Diagnosis
3.4. Pathological Findings
3.5. Histological Variants
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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First Author | Year of Publication | Number of Cases Described | Age | Clinical Symptoms | Tumor Largest Size (cm) * | Tumor Volume (cm3) | Pathologic Type | Therapy |
---|---|---|---|---|---|---|---|---|
David [5] | 1975 | 2 | 48; 65 | AUB, P, uterine prolapse | 12;15 | NS | 2 CDL | 2 TH |
Brand [6] | 1995 | 1 | 24 | Abdominal swelling | NS | NS | CDL | M |
Roth [1] | 1996 | 4 | 23–41 | Pelvic mass, AUB | 10–25 (25 cm) | NS | 4 CDL | 3 TH ± BSO, 1 M |
Menolascino-Bratta [7] | 1999 | 1 | 26 | P | 16 | 2240 | CDL | TH + BSO + A |
Roth [8] | 2000 | 1 | 46 | Menometrorrhagia | 34 | 11560 | CL | TH + BSO |
Cheuk [9] | 2002 | 1 | 55 | Menorrhagia, uterine prolapse | 10 | 360 | CL | TH + BSO |
Jordan [10] | 2002 | 6 | 34–46 | P, pelvic mass, menorrhagia | 10–22 (18 cm) | NS | 6 CDL (4 with intravenous leiomyomatosis) | 1 M, 5 subtotal/TH ± BSO |
Kim [11] | 2002 | 1 | 26 | AUB | 12 | NS | CDL | M |
Stewart [12] | 2003 | 1 | 58 | Pelvic mass | 16.4 | 1697.4 | CDL | TH + BSO+O |
Gurbuz [13] | 2005 | 1 | 67 | Abdominal mass | 10 | 120 | CL | TH + BSO |
Saeed [14] | 2006 | 1 | 27 | P, constipation | 41 | 13837.5 | CDL | TH + BSO |
Maimoon [15] | 2006 | 1 | 40 | Urinary retention | 10 | NS | CL with hydropic degeneration | TH + SO |
Mathew [16] | 2007 | 1 | 30 | P in pregnancy | 30 | NS | CL with hydropic degeneration | M |
Shelekhova [17] | 2007 | 2 | 73;48 | Pelvic mass, P | 8;9 | NS, 260 | 2 CDL (1 with intravascular growth, 1 with hydropic degeneration) | 2 TH + BSO |
Weissferdt [18] | 2007 | 1 | 52 | Menorrhagia, P | 6 | 72 | CDL with hydropic degeneration | TH + S |
Özcimen [19] | 2008 | 1 | 38 | AUB, P | 15 | 750 | CDL | TH + BS |
Misir [20] | 2009 | 6 | 35–57 | Pelvic mass, abdominal swelling, irregular menses, menorrhagia | 5–30 | NS | 6 CDL (2 epithelioid, 5 with hydropic degeneration) | 4 TH, 1 TH + BSO + O + A, 1 TH + SO |
Preda [4] | 2009 | 1 | 41 | Incidental | 9 | NS | CDL | TH + ovariectomy |
Adelipe [21] | 2010 | 1 | 37 | Menorrhagia | NS | NS | CDL | TH + O |
Agarwal [22] | 2010 | 1 | 52 | Polymenorrhagia | 10 | NS | CDL | TH |
Fukunaga [23] | 2010 | 4a | 35–56 | Constipation, abdominal mass, hypermenorrhea, P | 4–30 | NS | 4 CDLb | 4 TH ± BSO |
Aggarwal [24] | 2011 | 1 | 52 | Menorrhagia, uterine prolapse | 10 | NS | CL with hydropic degeneration | TH + SO |
Soleymani [25] | 2011 | 1 | 63 | AUB, P | 4 | 36 | Epithelioid CDL | TH + BSO |
Gezginig [26] | 2011 | 1 | 57 | P | 9 | 162 | CDL with intravascular growth | TH + BSO |
Ersöz [27] | 2011 | 1 | 51 | Menorrhagia | 8 | NS | CL | TH + BSO |
Kim [28] | 2013 | 1 | 43 | Pelvic mass and P | 13 | NS | CL | TH + BSO |
Sellami [29] | 2013 | 4c | 47–52 | Abdominal mass, hyper-menorrhea | 7–30 (10 cm) | NS | 4 CDLd | 1 M, 3 subtotal/TH ± BSO |
Bothale [30] | 2013 | 1 | 39 | Pelvic mass | 18 | 4320 | CL | TH |
Roth [31] | 2013 | 1 | 21 | Menorrhagia | 6.5 | 143 | CDL | M, then TH + BSO |
Makharoblidze [32] | 2013 | 1 | 42 | Menorrhagia, polymenorrhea, P | 31 | 27900 | CDL | TH |
Onu [33] | 2013 | 1 | 50 | Chronic lower back pain | 4 | 30 | CDL | RH + BSO + O + A |
Tanaka [34] | 2013 | 1 | 36 | Incidental | 10 | NS | CDL | M |
Chawla [35] | 2014 | 1 | 42 | Dysmenorrhea, P | 7 | 245 | Epithelioid CL | TH + BSO |
Meena [36] | 2014 | 1 | 40 | P | 14 | NS | CDL | TH + BSO |
Geynisman [37] | 2014 | 1 | 50 | P | 18 | 1890 | CDL | TH + BSO |
Blake [38] | 2014 | 1 | 56 | AUB | 20 | NS | CDL with adipocytic differentia-tion | RH + BSO + O |
Bas [39] | 2015 | 1 | 46 | P, menometrorrhagia | 22 | 5280 | CL | TH |
Saeki [40] | 2015 | 2 | 44; 31 | Incidental, P | 20;13 | NS, M **: 497.3 | 2 CDL | 1 TH + BSO, 1 GnRHanalogs + M |
Motoshima [41] | 2016 | 1 | 39 | Abdominal mass | 14 | 1176 | CDL with hydropic degeneration | M |
Raga [42] | 2016 | 1 | 28 | Menorrhagia, dysmenorrhea | 15 | 1435.4 | CDL | UPA + M |
Shimizu [43] | 2016 | 1 | 40 | Menorrhagia | 10 | 810 | CDL | TH + BS |
Xu [44] | 2016 | 4 | 37–55 | Pelvic mass | 7–30 | NS, 12000, 5250, NS | 4 CDL | 4 TH ± BSO |
Buckshee [45] | 2017 | 1 | 29 | P | 26 | 6760 | CDL | M |
Merchant [46] | 2017 | 1 | 35 | Dysmenorrhea and menorrhagia | 10 | 210 | CDL with intra-vascular growth | M |
Sonmez [47] | 2017 | 1 | 38 | P | 13.5 | 1275.8 | CL with symplastic features | M |
Rahman [48] | 2018 | 1 | 46 | P, abdominal swelling | 43 | 31648 | CDL with hydropic degeneration | TH + SO |
Smith [49] | 2018 | 1 | 42 | Pelvic vaginal cuff mass | 8 | 240 | CDL | Resection |
Khatun [50] | 2018 | 1 | 48 | P | 10 | 320 | CDL | TH + BSO |
Rocha [51] | 2018 | 1 | 38 | Menorrhagia, P | 25 | 13800 | CDL of the uterus and the ovary | TH + BSO |
Tuli [52] | 2018 | 1 | 50 | Menorrhagia | 11.8 | 681.5 | CDL with hydropic degeneration | TH + BSO |
Jamal [53] | 2019 | 1 | 60 | P | 4 | NS | CDL | TH |
Kashima [54] | 2019 | 1 | 43 | Menorrhagia | 22 | 1694 | CDL with intravascular growth | TH + BSO |
Özdemir [55] | 2019 | 1 | 34 | Menorrhagia, P | 17 | NS | CDL | TH |
Lenz [56] | 2020 | 1 | 64 | P | NS | NS | CDL | TH + R |
Parker [57] | 2020 | 1 | 39 | Abdominal mass | 28 | NS | CL | M |
Niziurski [58] | 2020 | 1 | 41 | AUB, pelvic mass | 20 | 5100 | CDL with hydropic degeneration | TH + BSO + intestine resection |
Buonomo [3] | 2020 | 13 | 30–67 | Pelvic mass, P, incidental, metrorrhagia | 4–14,7 | 489.6, 280, 132.8, 305, 770, 480, 210, 49, 165, 1411 M **: 157.5, 106.5, 1188 | 3 CDL, 10 CL | 3 M, 4 TH + BSO, 2 TH + BS, 1 TH + S, 2 RH + BSO, 1 RH + S + O |
Pelvic Ultrasound | Magnetic Resonance Imaging | During Surgery |
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Gross Pathology | Microscopic Elements |
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Positivity [9,20] | Negativity [25] |
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Buonomo, F.; Bussolaro, S.; Fiorillo, C.d.A.; Giorda, G.; Romano, F.; Biffi, S.; Ricci, G. The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature. Int. J. Environ. Res. Public Health 2021, 18, 8521. https://doi.org/10.3390/ijerph18168521
Buonomo F, Bussolaro S, Fiorillo CdA, Giorda G, Romano F, Biffi S, Ricci G. The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature. International Journal of Environmental Research and Public Health. 2021; 18(16):8521. https://doi.org/10.3390/ijerph18168521
Chicago/Turabian StyleBuonomo, Francesca, Sofia Bussolaro, Clarice de Almeida Fiorillo, Giorgio Giorda, Federico Romano, Stefania Biffi, and Giuseppe Ricci. 2021. "The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature" International Journal of Environmental Research and Public Health 18, no. 16: 8521. https://doi.org/10.3390/ijerph18168521
APA StyleBuonomo, F., Bussolaro, S., Fiorillo, C. d. A., Giorda, G., Romano, F., Biffi, S., & Ricci, G. (2021). The Management of the Cotyledonoid Leiomyoma of the Uterus: A Narrative Review of the Literature. International Journal of Environmental Research and Public Health, 18(16), 8521. https://doi.org/10.3390/ijerph18168521