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Article

Differential Kinetics of Cycle Threshold Values during Admission by Symptoms among Patients with Mild COVID-19: A Prospective Cohort Study

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Division of Innovation for Medical Information Technology, The Jikei University School of Medicine, Tokyo 105-8461, Japan
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Allm, Inc., Yushin Bldg. Shinkan 2F, 3-27-11 Shibuya, Shibuya-ku, Tokyo 150-0002, Japan
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Division of Molecular Epidemiology, The Jikei University School of Medicine, Tokyo 105-8461, Japan
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Department of Global Health Promotion, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
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Department of Neurosurgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan
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Infectious Disease Department, Team Medical Clinic, Tokyo 105-0003, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Jozsef Z. Farkas
Int. J. Environ. Res. Public Health 2021, 18(15), 8181; https://doi.org/10.3390/ijerph18158181
Received: 27 June 2021 / Revised: 28 July 2021 / Accepted: 29 July 2021 / Published: 2 August 2021
(This article belongs to the Section Infectious Disease Epidemiology)
In the coronavirus disease 2019 (COVID-19) pandemic, more than half of the cases of transmission may occur via asymptomatic individuals, which makes it difficult to contain. However, whether viral load in the throat during admission is different between asymptomatic and symptomatic patients is not well known. By conducting a prospective cohort study of patients with asymptomatic or mild COVID-19, cycle threshold (Ct) values of the polymerase chain reaction test for COVID-19 were examined every other day during admission. The Ct values during admission increased more steadily in symptomatic patients and febrile patients than in asymptomatic patients, with significance (p = 0.01 and p = 0.004, respectively), although the Ct values as a whole were not significantly different between the two groups. Moreover, the Ct values as a whole were higher in patients with dysosmia/dysgeusia than in those without it (p = 0.02), whereas they were lower in patients with a headache than those without (p = 0.01). Patients who were IgG-positive at discharge maintained higher Ct values, e.g., more than 35, during admission than those with IgG-negative (p = 0.03). Assuming that viral load and Ct values are negatively associated, the viral loads as a whole and their changes by time may be different by symptoms and immune reaction, i.e., IgG-positive at discharge. View Full-Text
Keywords: coronavirus disease 2019; COVID-19; SARS-CoV-2; mild; asymptomatic; febrile; afebrile; PCR; Ct; cycle threshold coronavirus disease 2019; COVID-19; SARS-CoV-2; mild; asymptomatic; febrile; afebrile; PCR; Ct; cycle threshold
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MDPI and ACS Style

Sakano, T.; Urashima, M.; Takao, H.; Takeshita, K.; Kobashi, H.; Fujiwara, T. Differential Kinetics of Cycle Threshold Values during Admission by Symptoms among Patients with Mild COVID-19: A Prospective Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 8181. https://doi.org/10.3390/ijerph18158181

AMA Style

Sakano T, Urashima M, Takao H, Takeshita K, Kobashi H, Fujiwara T. Differential Kinetics of Cycle Threshold Values during Admission by Symptoms among Patients with Mild COVID-19: A Prospective Cohort Study. International Journal of Environmental Research and Public Health. 2021; 18(15):8181. https://doi.org/10.3390/ijerph18158181

Chicago/Turabian Style

Sakano, Teppei, Mitsuyoshi Urashima, Hiroyuki Takao, Kohei Takeshita, Hiroe Kobashi, and Takeo Fujiwara. 2021. "Differential Kinetics of Cycle Threshold Values during Admission by Symptoms among Patients with Mild COVID-19: A Prospective Cohort Study" International Journal of Environmental Research and Public Health 18, no. 15: 8181. https://doi.org/10.3390/ijerph18158181

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