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Article

The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study

1
Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia
2
School of Biological and Health Sciences, Technological University Dublin, D07 EWV4 Dublin, Ireland
*
Author to whom correspondence should be addressed.
Academic Editors: David Berrigan and Jaeku Kang
Int. J. Environ. Res. Public Health 2021, 18(15), 8169; https://doi.org/10.3390/ijerph18158169
Received: 25 May 2021 / Revised: 26 July 2021 / Accepted: 28 July 2021 / Published: 2 August 2021
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
Evidence supports an association between low magnesium (Mg) intake and coronary heart disease and between Mg intake and endothelial function. The aim of this study was to assess the effect of one week of Mg supplementation on endothelial function, assessed by flow mediated dilatation (FMD). Nineteen healthy men and women completed this cross-over pilot study in which participants were randomised to take an over-the-counter magnesium supplement for one week or to follow their usual diet. Weight, FMD and blood pressure (BP) were taken on completion of each intervention and 24 h urine collections and blood samples were taken to assess compliance. Baseline serum Mg was within normal range for all participants. Urinary Mg and urinary magnesium-creatinine ratio (Mg/Cr) significantly increased between interventions, (p = 0.03, p = 0.005, respectively). No significant differences in FMD or BP were found between the interventions. A significant negative correlation was seen between age and FMD (r = −0.496, p = 0.031). When adjusted for age, saturated fat was negatively associated with FMD (p = 0.045). One week of Mg supplementation did not improve FMD in a healthy population. View Full-Text
Keywords: magnesium; flow mediated dilatation; endothelial function magnesium; flow mediated dilatation; endothelial function
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MDPI and ACS Style

Byrne, J.; Murphy, C.; Keogh, J.B.; Clifton, P.M. The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 8169. https://doi.org/10.3390/ijerph18158169

AMA Style

Byrne J, Murphy C, Keogh JB, Clifton PM. The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study. International Journal of Environmental Research and Public Health. 2021; 18(15):8169. https://doi.org/10.3390/ijerph18158169

Chicago/Turabian Style

Byrne, Jennifer, Caitríona Murphy, Jennifer B. Keogh, and Peter M. Clifton 2021. "The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study" International Journal of Environmental Research and Public Health 18, no. 15: 8169. https://doi.org/10.3390/ijerph18158169

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