Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Setting
2.2. Preoperative Major Psychiatric Disorders
2.3. Physical Comorbidities
2.4. Surgical Outcomes: In-Hospitalization and Post-Discharge Outcomes
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
- GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017, 390, 1211–1259. [Google Scholar] [CrossRef] [Green Version]
- Kalichman, L.; Cole, R.; Kim, D.H.; Li, L.; Suri, P.; Guermazi, A.; Hunter, D.J. Spinal stenosis prevalence and association with symptoms: The Framingham Study. Spine J. 2009, 9, 545–550. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Deyo, R.A.; Mirza, S.K.; Martin, B.I.; Kreuter, W.; Goodman, D.C.; Jarvik, J.G. Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults. JAMA 2010, 303, 1259–1265. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sivasubramaniam, V.; Patel, H.C.; Ozdemir, B.A.; Papadopoulos, M.C. Trends in hospital admissions and surgical procedures for degenerative lumbar spine disease in England: A 15-year time-series study. BMJ Open 2015, 5, e009011. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Reynolds, C.F.; Cuijpers, P.; Patel, V.; Cohen, A.; Dias, A.; Chowdhary, N.; Okereke, O.I.; Dew, M.A.; Anderson, S.J.; Mazumdar, S.; et al. Early intervention to reduce the global health and economic burden of major depression in older adults. Annu Rev. Public Health 2012, 33, 123–135. [Google Scholar] [CrossRef] [Green Version]
- Fu, T.S.; Lee, C.S.; Gunnell, D.; Lee, W.C.; Cheng, A.T. Changing trends in the prevalence of common mental disorders in Taiwan: A 20-year repeated cross-sectional survey. Lancet 2013, 381, 235–241. [Google Scholar] [CrossRef]
- Koyanagi, A.; Kohler-Forsberg, O.; Benros, M.E.; Munk Laursen, T.; Haro, J.M.; Nordentoft, M.; Hjorthoj, C. Mortality in unipolar depression preceding and following chronic somatic diseases. Acta Psychiatr. Scand. 2018, 138, 500–508. [Google Scholar] [CrossRef]
- Mitchell, A.J.; Pereira, I.E.; Yadegarfar, M.; Pepereke, S.; Mugadza, V.; Stubbs, B. Breast cancer screening in women with mental illness: Comparative meta-analysis of mammography uptake. Br. J. Psychiatry 2014, 205, 428–435. [Google Scholar] [CrossRef]
- Musselman, D.L.; Evans, D.L.; Nemeroff, C.B. The relationship of depression to cardiovascular disease: Epidemiology, biology, and treatment. Arch. Gen. Psychiatry 1998, 55, 580–592. [Google Scholar] [CrossRef]
- Spiegel, D.; Sands, S.; Koopman, C. Pain and depression in patients with cancer. Cancer 1994, 74, 2570–2578. [Google Scholar] [CrossRef]
- Hale, J.M.; Schneider, D.C.; Gampe, J.; Mehta, N.K.; Myrskyla, M. Trends in the Risk of Cognitive Impairment in the United States, 1996–2014. Epidemiology 2020, 31, 745–754. [Google Scholar] [CrossRef] [PubMed]
- Gerhardt, J.; Bette, S.; Janssen, I.; Gempt, J.; Meyer, B.; Ryang, Y.M. Is Eighty the New Sixty? Outcomes and Complications after Lumbar Decompression Surgery in Elderly Patients over 80 Years of Age. World Neurosurg. 2018, 112, e555–e560. [Google Scholar] [CrossRef] [PubMed]
- Hajek, A.; Brettschneider, C.; Röhr, S.; Gühne, U.; Van Der Leeden, C.; Lühmann, D.; Mamone, S.; Wiese, B.; Weyerer, S.; Werle, J.; et al. Which Factors Contribute to Frailty among the Oldest Old? Results of the Multicentre Prospective AgeCoDe and AgeQualiDe Study. Gerontology 2020, 66, 460–466. [Google Scholar] [CrossRef]
- Trief, P.M.; Grant, W.; Fredrickson, B. A prospective study of psychological predictors of lumbar surgery outcome. Spine 2000, 25, 2616–2621. [Google Scholar] [CrossRef] [PubMed]
- Hoy, D.; Brooks, P.; Blyth, F.; Buchbinder, R. The Epidemiology of low back pain. Best Pract. Res. Clin. Rheumatol. 2010, 24, 769–781. [Google Scholar] [CrossRef]
- Jegan, N.R.; Brugger, M.; Viniol, A.; Strauch, K.; Barth, J.; Baum, E.; Leonhardt, C.; Becker, A. Psychological risk and protective factors for disability in chronic low back pain—A longitudinal analysis in primary care. BMC Musculoskelet. Dis. 2017, 18, 114. [Google Scholar] [CrossRef] [Green Version]
- Trief, P.M.; Ploutz-Snyder, R.; Fredrickson, B.E. Emotional health predicts pain and function after fusion: A prospective multicenter study. Spine 2006, 31, 823–830. [Google Scholar] [CrossRef] [PubMed]
- Mainio, A.; Tuunanen, S.; Hakko, H.; Niemela, A.; Koivukangas, J.; Rasanen, P. Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: A follow-up from 1990 to 2003. Eur. Arch. Psychiatry Clin. Neurosci. 2006, 256, 516–521. [Google Scholar] [CrossRef]
- Menendez, M.E.; Neuhaus, V.; Bot, A.G.; Ring, D.; Cha, T.D. Psychiatric disorders and major spine surgery: Epidemiology and perioperative outcomes. Spine 2014, 39, E111–E122. [Google Scholar] [CrossRef] [Green Version]
- Diebo, B.G.; Lavian, J.D.; Murray, D.P.; Liu, S.; Shah, N.V.; Beyer, G.A.; Segreto, F.A.; Bloom, L.; Vasquez-Montes, D.; Day, L.M.; et al. The Impact of Comorbid Mental Health Disorders on Complications Following Adult Spinal Deformity Surgery with Minimum 2-Year Surveillance. Spine 2018, 43, 1176–1183. [Google Scholar] [CrossRef]
- Najera, K.; Fagan, B.M.; Thompson, P.M. SNAP-25 in Major Psychiatric Disorders: A Review. Neuroscience 2019, 420, 79–85. [Google Scholar] [CrossRef] [PubMed]
- Semahegn, A.; Torpey, K.; Manu, A.; Assefa, N.; Tesfaye, G.; Ankomah, A. Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis. Syst. Rev. 2020, 9, 17. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Jackson, K.L.; Rumley, J.; Griffith, M.; Agochukwu, U.; DeVine, J. Correlating Psychological Comorbidities and Outcomes After Spine Surgery. Glob. Spine J. 2020, 10, 929–939. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Chien, I.C.; Bih, S.H.; Chou, Y.J.; Lin, C.H.; Lee, W.G.; Chou, P. Trends in the use of psychotropic drugs in Taiwan: A population-based national health insurance study, 1997–2004. Psychiatr. Serv. 2007, 58, 554–557. [Google Scholar] [CrossRef] [PubMed]
- Chien, I.C.; Chou, Y.J.; Lin, C.H.; Bih, S.H.; Chou, P. Prevalence of psychiatric disorders among National Health Insurance enrollees in Taiwan. Psychiatr. Serv. 2004, 55, 691–697. [Google Scholar] [CrossRef]
- Sivaganesan, A.; Zuckerman, S.; Khan, I.; Nian, H.; Harrell, F.E., Jr.; Pennings, J.S.; Harbaugh, R.; Foley, K.T.; Bydon, M.; Asher, A.L.; et al. Predictive Model for Medical and Surgical Readmissions Following Elective Lumbar Spine Surgery: A National Study of 33,674 Patients. Spine 2019, 44, 588–600. [Google Scholar] [CrossRef] [PubMed]
- Dietz, N.; Sharma, M.; Alhourani, A.; Ugiliweneza, B.; Wang, D.; Nuno, M.A.; Drazin, D.; Boakye, M. Bundled Payment Models in Spine Surgery: Current Challenges and Opportunities, a Systematic Review. World Neurosurg. 2019, 123, 177–183. [Google Scholar] [CrossRef]
- Kessler, R.C.; Chiu, W.T.; Demler, O.; Merikangas, K.R.; Walters, E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 2005, 62, 617–627. [Google Scholar] [CrossRef] [Green Version]
- Berk, M.; Berk, L.; Castle, D. A collaborative approach to the treatment alliance in bipolar disorder. Bipolar Dis. 2004, 6, 504–518. [Google Scholar] [CrossRef]
- Tu, H.P.; Lin, C.H.; Hsieh, H.M.; Jiang, H.J.; Wang, P.W.; Huang, C.J. Prevalence of anxiety disorder in patients with type 2 diabetes: A nationwide population-based study in Taiwan 2000–2010. Psychiatr. Q. 2017, 88, 75–91. [Google Scholar] [CrossRef]
- Zhu, Y.; Chen, Y.; Crimmins, E.M.; Zissimopoulos, J.M. Sex, Race, and Age Differences in Prevalence of Dementia in Medicare Claims and Survey Data. J. Gerontol. Ser. B 2021, 76, 596–606. [Google Scholar] [CrossRef]
- Brown, A.; Alas, H.; Bortz, C.; Pierce, K.E.; Vasquez-Montes, D.; Ihejirika, R.C.; Segreto, F.A.; Haskel, J.; Kaplan, D.J.; Segar, A.H.; et al. Patients with psychiatric diagnoses have increased odds of morbidity and mortality in elective orthopedic surgery. J. Clin. Neurosci. 2021, 84, 42–45. [Google Scholar] [CrossRef]
- Jiménez-Almonte, J.H.; Hautala, G.S.; Abbenhaus, E.J.; Grabau, J.D.; Nzegwu, I.N.; Mehdi, S.K.; Akhtar, Z.M.; Liu, B.; Jacobs, C.A.; Cassidy, R.C. Spine patients demystified: What are the predictive factors of poor surgical outcome in patients after elective cervical and lumbar spine surgery? Spine J. 2020, 20, 1529–1534. [Google Scholar] [CrossRef] [PubMed]
- Fried, D.A.; Sadeghi-Nejad, H.; Gu, D.; Zhou, S.; He, W.; Giordano, S.H.; Pentakota, S.R.; Demissie, K.; Helmer, D.; Shen, C. Impact of serious mental illness on the treatment and mortality of older patients with locoregional high-grade (nonmetastatic) prostate cancer: Retrospective cohort analysis of 49 985 SEER-Medicare patients diagnosed between 2006 and 2013. Cancer Med. 2019, 8, 2612–2622. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Donath, L.; Puta, C.; Boettger, S.; Mueller, H.J.; Faude, O.; Meyer, T.; Bar, K.J.; Gabriel, H.H. Ventilatory inefficiency in major depressive disorder: A potential adjunct for cardiac risk stratification in depressive disorders? Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2010, 34, 882–887. [Google Scholar] [CrossRef] [PubMed]
- Yohannes, A.M.; Mülerová, H.; Lavoie, K.; Vestbo, J.; Rennard, S.I.; Wouters, E.; Hanania, N.A. The Association of Depressive Symptoms with Rates of Acute Exacerbations in Patients With COPD: Results From a 3-year Longitudinal Follow-up of the ECLIPSE Cohort. J. Am. Med. Dir. Assoc. 2017, 18, 955–959.e6. [Google Scholar] [CrossRef]
- Schenker, Y.; Stewart, A.; Na, B.; Whooley, M.A. Depressive Symptoms and Perceived Doctor-Patient Communication in the Heart and Soul Study. J. Gen. Intern. Med. 2009, 24, 550–556. [Google Scholar] [CrossRef] [Green Version]
- Simon, G.E.; Vonkorff, M.; Piccinelli, M.; Fullerton, C.; Ormel, J. An International Study of the Relation between Somatic Symptoms and Depression. N. Engl. J. Med. 1999, 341, 1329–1335. [Google Scholar] [CrossRef]
- Johansson, P.; Nieuwenhuis, M.; Lesman-Leegte, I.; Van Veldhuisen, D.J.; Jaarsma, T. Depression and the delay between symptom onset and hospitalization in heart failure patients. Eur. J. Heart Fail. 2011, 13, 214–219. [Google Scholar] [CrossRef]
- King, W.C.; Hinerman, A.S.; White, G.E.; Courcoulas, A.P.; Belle, S.H. Associations Between Physical Activity and Changes in Depressive Symptoms and Health-Related Quality of Life Across 7 Years Following Roux-en-Y Gastric Bypass Surgery: A Multicenter Prospective Cohort Study. Ann. Surg. 2020. [Google Scholar] [CrossRef]
- Goodwin, R.D. Association between physical activity and mental disorders among adults in the United States. Prev. Med. 2003, 36, 698–703. [Google Scholar] [CrossRef]
- Suetani, S.; Mamun, A.; Williams, G.M.; Najman, J.M.; McGrath, J.J.; Scott, J.G. The association between the longitudinal course of common mental disorders and subsequent physical activity status in young adults: A 30-year birth cohort study. J. Psychiatr. Res. 2019, 109, 173–177. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- King, A.P.; Abelson, J.L.; Gholami, B.; Upchurch, G.R., Jr.; Henke, P.; Graham, L.; Liberzon, I. Presurgical Psychological and Neuroendocrine Predictors of Psychiatric Morbidity After Major Vascular Surgery: A Prospective Longitudinal Study. Psychosom. Med. 2015, 77, 993–1005. [Google Scholar] [CrossRef] [Green Version]
- Carreon, L.Y.; Jespersen, A.B.; Stottrup, C.C.; Hansen, K.H.; Andersen, M.O. Is the Hospital Anxiety and Depression Scale Associated with Outcomes After Lumbar Spine Surgery? Glob. Spine J. 2020, 10, 266–271. [Google Scholar] [CrossRef] [PubMed]
- Maratos, E.C.; Trivedi, R.; Richards, H.; Seeley, H.; Laing, R.J. Psychological distress does not compromise outcome in spinal surgery. Br. J. Neurosurg. 2012, 26, 466–471. [Google Scholar] [CrossRef]
- Joe, S.; Lee, J.S. Association between non-compliance with psychiatric treatment and non-psychiatric service utilization and costs in patients with schizophrenia and related disorders. BMC Psychiatry 2016, 16, 444. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Shivakumar, V.; Kalmady, S.V.; Rajasekaran, A.; Chhabra, H.; Anekal, A.C.; Narayanaswamy, J.C.; Ravi, V.; Gangadhar, B.N.; Venkatasubramanian, G. Telomere length and its association with hippocampal gray matter volume in antipsychotic-naive/free schizophrenia patients. Psychiatry Res. Neuroimaging 2018, 282, 11–17. [Google Scholar] [CrossRef]
- Wu, C.S.; Gau, S.S. Association Between Antipsychotic Treatment and Advanced Diabetes Complications Among Schizophrenia Patients with Type 2 Diabetes Mellitus. Schizophr. Bull. 2016, 42, 703–711. [Google Scholar] [CrossRef] [Green Version]
- Pereira, B.J.; de Holanda, C.V.; Ribeiro, C.A.; Holanda, L.F.; Cabral, C.D.; Caravalho, L.L.; de Oliveira, J.G. Spinal surgery for degenerative lumbar spine disease: Predictors of outcome. Clin. Neurol. Neurosurg. 2016, 140, 1–5. [Google Scholar] [CrossRef]
- Pumberger, M.; Chiu, Y.L.; Ma, Y.; Girardi, F.P.; Vougioukas, V.; Memtsoudis, S.G. Perioperative mortality after lumbar spinal fusion surgery: An analysis of epidemiology and risk factors. Eur. Spine J. 2012, 21, 1633–1639. [Google Scholar] [CrossRef] [Green Version]
- Shen, Y.; Silverstein, J.C.; Roth, S. In-hospital complications and mortality after elective spinal fusion surgery in the united states: A study of the nationwide inpatient sample from 2001 to 2005. J. Neurosurg. Anesthesiol. 2009, 21, 21–30. [Google Scholar] [CrossRef] [PubMed]
- Rhee, T.G.; Rosenheck, R.A. Initiation of new psychotropic prescriptions without a psychiatric diagnosis among US adults: Rates, correlates, and national trends from 2006 to 2015. Health Serv. Res. 2019, 54, 139–148. [Google Scholar] [CrossRef] [PubMed]
Control (n = 9061) | Major Psychiatric Disorders (n = 1048) | p | |
---|---|---|---|
Demographic data | |||
Age | 57.1 ± 15.2 | 59.5 ± 14.4 | <0.001 *** |
Female, n (%) | 4518 (49.9) | 651 (62.1) | <0.001 *** |
Diagnosis, n (%) | <0.001 *** | ||
Disc displacement | 4050 (44.7) | 409 (39.0) | |
Spondylosis | 538 (5.9) | 58 (5.5) | |
Spinal stenosis | 4473 (49.4) | 581 (55.4) | |
Spine procedure, n (%) | 0.193 | ||
Discectomy | 4387 (48.4) | 489 (46.7) | |
Laminectomy | 2922 (32.3) | 332 (31.7) | |
Spine fusion | 1752 (19.3) | 227 (21.6) | |
Number of spine procedure | 0.738 | ||
1 | 7575 (83.7) | 871 (83.3) | |
≧2 | 1478 (16.3) | 175 (16.7) | |
Urbanization, n (%) | 0.906 | ||
Urban | 4911 (54.2) | 566 (54.0) | |
Rural | 4150 (45.8) | 482 (46.0) | |
Physical comorbidities, n (%) | |||
Hypertension | 5624 (62.1) | 667 (63.6) | 0.319 |
Diabetes | 3294 (36.4) | 383 (36.5) | 0.903 |
Hyperlipidemia | 3957 (43.7) | 489 (46.7) | 0.065 |
Chronic kidney disease | 895 (9.9) | 105 (10.0) | 0.884 |
Coronary heart disease | 3153 (34.8) | 369 (35.2) | 0.791 |
Osteoporosis | 2324 (25.6) | 304 (29.0) | 0.019 * |
COPD | 3055 (33.7) | 353 (33.7) | 0.983 |
Cerebrovascular disease | 2227 (24.6) | 296 (28.2) | 0.009 ** |
Fibromyalgia/myositis | 4415 (48.7) | 506 (48.3) | 0.786 |
Control (n = 9061) | Major Psychiatric Disorders (n = 1048) | p | |
---|---|---|---|
In-hospital outcomes | |||
Hospitalization stay, days | 9.3 ± 6.7 | 9.6 ± 6.7 | 0.242 |
Ventilator use, n (%) | 202 (2.2) | 39 (3.7) | 0.003 ** |
Post-discharge outcomes | |||
Rehabilitation, n (%) | 4199 (46.3) | 540 (51.5) | 0.001 ** |
Readmission, n (%) | 1185 (13.1) | 129 (12.3) | 0.483 |
Major Psychiatric Disorders | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Anxiety | p | Depression | p | Bipolar | p | Schizophrenia | p | Dementia | p | |
Total number (%) | 494 (4.9) | 667 (6.6) | 68 (0.7) | 38 (0.4) | 197 (1.9) | |||||
Demographic data | ||||||||||
Age, years | 57.6 ± 14.3 | 0.426 | 58.1 ± 13.7 | 0.063 | 57.4 ± 14.4 | 0.843 | 48.8 ± 15.1 | <0.001 *** | 70.1 ± 10.9 | <0.001 *** |
Female, n (%) | 298 (60.3) | <0.001 *** | 447 (67.0) | <0.001 *** | 47 (69.1) | 0.002 ** | 18 (47.4) | 0.759 | 111 (56.3) | 0.072 |
Diagnosis, n (%) | 0.062 | 0.057 | 0.021 * | 0.244 | <0.001 *** | |||||
Disc displacement | 203 (41.1) | 268 (40.2) | 19 (27.9) | 20 (52.6) | 53 (26.9) | |||||
Spondylosis | 22 (4.5) | 38 (5.7) | 5 (7.4) | 0 (0.0) | 9 (4.6) | |||||
Spinal stenosis | 269 (54.5) | 361 (54.1) | 44 (64.7) | 18 (47.4) | 135 (68.5) | |||||
Spine procedure, n (%) | 0.173 | 0.559 | 0.224 | 0.247 | <0.001 *** | |||||
Discectomy | 257 (52.0) | 313 (46.9) | 26 (38.2) | 23 (60.5) | 76 (38.6) | |||||
Laminectomy | 140 (28.3) | 214 (32.1) | 25 (36.8) | 11 (28.9) | 62 (31.5) | |||||
Spinal fusion | 97 (19.6) | 140 (21.0) | 17 (25.0) | 4 (10.5) | 59 (29.9) | |||||
Physical comorbidities, n (%) | ||||||||||
Hypertension | 301 (60.9) | 0.612 | 409 (61.3) | 0.701 | 42 (61.8) | 0.959 | 19 (50.0) | 0.126 | 150 (76.1) | <0.001 *** |
Diabetes mellitus | 167 (33.8) | 0.251 | 230 (34.5) | 0.332 | 26 (38.2) | 0.748 | 7 (18.4) | 0.022 * | 89 (45.2) | 0.011 * |
Hyperlipidemia | 235 (47.6) | 0.089 | 316 (47.4) | 0.063 | 29 (42.6) | 0.865 | 11 (28.9) | 0.068 | 84 (42.6) | 0.773 |
Chronic kidney disease | 40 (8.1) | 0.195 | 60 (9.0) | 0.460 | 8 (11.8) | 0.604 | 1 (2.6) | 0.174 | 33 (16.8) | 0.001 ** |
Coronary heart disease | 160 (32.4) | 0.273 | 230 (34.5) | 0.869 | 23 (33.8) | 0.867 | 9 (23.7) | 0.151 | 77 (39.1) | 0.211 |
Osteoporosis | 129 (26.1) | 0.818 | 198 (29.7) | 0.022 * | 20 (29.4) | 0.479 | 9 (23.7) | 0.782 | 75 (38.1) | <0.001 *** |
COPD | 159 (32.2) | 0.484 | 216 (32.4) | 0.482 | 22 (32.4) | 0.813 | 10 (26.3) | 0.335 | 80 (40.6) | 0.043 * |
Cerebrovascular disease | 118 (23.9) | 0.728 | 181 (27.1) | 0.139 | 12 (17.6) | 0.186 | 5 (13.2) | 0.103 | 92 (46.7) | <0.001 *** |
Fibromyalgia/myositis | 229 (46.4) | 0.305 | 349 (52.3) | 0.073 | 38 (55.9) | 0.239 | 16 (42.1) | 0.415 | 78 (39.6) | 0.011 * |
In-hospital outcomes | ||||||||||
Hospitalization stay, days | 8.8 ± 5.3 | 0.033 * | 9.5 ± 6.4 | 0.518 | 11.1 ± 8.0 | 0.029 * | 9.7 ± 7.4 | 0.714 | 11.0 ± 8.6 | <0.001 *** |
Ventilator use, n (%) | 16 (3.2) | 0.143 | 23 (3.4) | 0.043 * | 3 (4.4) | 0.196 | 1 (2.6) | 0.577 | 11 (5.6) | 0.002 ** |
Post-discharge outcomes | ||||||||||
Rehabilitation, n (%) | 245 (49.6) | 0.158 | 350 (52.5) | 0.002 ** | 41 (60.3) | 0.022 * | 22 (57.9) | 0.154 | 95 (48.2) | 0.600 |
Readmission, n (%) | 58 (11.7) | 0.390 | 92 (13.8) | 0.598 | 10 (14.7) | 0.692 | 6 (15.8) | 0.621 | 19 (9.6) | 0.156 |
Variables | Anxiety | Depression | Bipolar | Schizophrenia | Dementia | |||||
---|---|---|---|---|---|---|---|---|---|---|
OR 95% CI | p | OR 95% CI | p | OR 95% CI | p | OR 95% CI | p | OR 95% CI | p | |
Patients vs. controls | ||||||||||
In-hospital outcomes | ||||||||||
Hospitalization stay a | 0.77 (0.60, 0.98) | 0.035 * | 1.02 (0.87, 1.20) | 0.798 | 1.77 (1.08, 2.89) | 0.024 * | 1.77 (0.92, 3.41) | 0.088 | 1.05 (0.78, 1.40) | 0.759 |
Ventilator use | 1.51 (0.89, 2.55) | 0.125 | 1.62 (1.04, 2.54) | 0.033 * | 2.13 (0.65, 6.98) | 0.214 | 2.07 (0.27, 15.80) | 0.482 | 1.32 (0.70, 2.51) | 0.391 |
Post-discharge outcomes | ||||||||||
Rehabilitation | 1.12 (0.93, 1.34) | 0.220 | 1.25 (1.06, 1.47) | 0.007 ** | 1.69 (1.04, 2.76) | 0.035 * | 1.78 (0.93, 3.40) | 0.083 | 1.02 (0.75, 1.38) | 0.914 |
Readmission | 0.91 (0.69, 1.21) | 0.513 | 1.12 (0.89, 1.41) | 0.334 | 1.20 (0.61, 2.36) | 0.593 | 1.27 (0.53, 3.05) | 0.598 | 0.78 (0.48, 1.26) | 0.309 |
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Huang, Y.-C.; Chang, C.-H.; Lin, C.-L.; Wang, L.-J.; Hsu, C.-W.; Su, Y.-F.; Lo, Y.-C.; Hung, C.-F.; Hsieh, Y.-Y.; Chen, C.-S. Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease. Int. J. Environ. Res. Public Health 2021, 18, 5391. https://doi.org/10.3390/ijerph18105391
Huang Y-C, Chang C-H, Lin C-L, Wang L-J, Hsu C-W, Su Y-F, Lo Y-C, Hung C-F, Hsieh Y-Y, Chen C-S. Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease. International Journal of Environmental Research and Public Health. 2021; 18(10):5391. https://doi.org/10.3390/ijerph18105391
Chicago/Turabian StyleHuang, Yu-Chi, Chih-Hui Chang, Chih-Lung Lin, Liang-Jen Wang, Chih-Wei Hsu, Yu-Feng Su, Yi-Ching Lo, Chi-Fa Hung, Yun-Yu Hsieh, and Cheng-Sheng Chen. 2021. "Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease" International Journal of Environmental Research and Public Health 18, no. 10: 5391. https://doi.org/10.3390/ijerph18105391