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The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study

1
Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia
2
Department of Biological Sciences, Technological University Dublin, D07 EWV4 Dublin, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Stefano Ballestri
Int. J. Environ. Res. Public Health 2021, 18(10), 5303; https://doi.org/10.3390/ijerph18105303
Received: 24 March 2021 / Revised: 29 April 2021 / Accepted: 14 May 2021 / Published: 17 May 2021
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
Magnesium (Mg) deficiency might be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim of this study was to determine the acute effect of an oral Mg supplement as compared to control on endothelial function assessed by flow-mediated dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9 kg/m2) completed this randomized cross-over study. Blood pressure (BP) and FMD were measured and blood samples were taken before participants drank 200 mL water, with or without an over the counter Mg supplement (450 mg and 300 mg for men and women). Measurements were repeated at 60 and 120 min. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = 0.037). A difference of −0.085 mm in FMD was observed 60-min post drink in the control group, as compared to baseline FMD, and no difference was observed in the supplement group as compared to baseline. Despite the non-significant interaction between treatment and time on FMD, once adjusted for baseline, the difference seen in the control group and the lack of change in the supplement group at 60 min post-drink suggests that Mg might attenuate the reduction in FMD post-prandially. View Full-Text
Keywords: magnesium 1; flow mediated dilatation 2; endothelial function magnesium 1; flow mediated dilatation 2; endothelial function
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MDPI and ACS Style

Murphy, C.; Byrne, J.; Keogh, J.B.; Headland, M.L.; Clifton, P.M. The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study. Int. J. Environ. Res. Public Health 2021, 18, 5303. https://doi.org/10.3390/ijerph18105303

AMA Style

Murphy C, Byrne J, Keogh JB, Headland ML, Clifton PM. The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study. International Journal of Environmental Research and Public Health. 2021; 18(10):5303. https://doi.org/10.3390/ijerph18105303

Chicago/Turabian Style

Murphy, Caitríona; Byrne, Jennifer; Keogh, Jennifer B.; Headland, Michelle L.; Clifton, Peter M. 2021. "The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study" Int. J. Environ. Res. Public Health 18, no. 10: 5303. https://doi.org/10.3390/ijerph18105303

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