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Open AccessArticle

Gene-Environment Interaction between the IL1RN Variants and Childhood Environmental Tobacco Smoke Exposure in Asthma Risk

1
Division of Biostatistics, Department of Population Health, School of Medicine (SOM), New York University, New York, NY 10016, USA
2
Department of Environmental Medicine, SOM, New York University, New York, NY 10016, USA
3
Division of Pulmonary and Critical Care Medicine, Department of Medicine, SOM, New York University, New York, NY 10016, USA
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(6), 2036; https://doi.org/10.3390/ijerph17062036
Received: 28 February 2020 / Revised: 16 March 2020 / Accepted: 17 March 2020 / Published: 19 March 2020
(1) Background: Variants of the interleukin-1 receptor antagonist (IL1RN) gene, encoding an anti-inflammatory cytokine, are associated with asthma. Asthma is a chronic inflammatory disease of the airway influenced by interactions between genetic variants and environmental factors. We discovered a gene–environment interaction (GEI) of IL1RN polymorphisms with childhood environmental tobacco smoke (ETS) exposure on asthma susceptibility in an urban adult population. (2) Methods: DNA samples from the NYU/Bellevue Asthma Registry were genotyped for tag SNPs in IL1RN in asthma cases and unrelated healthy controls. Logistic regressions were used to study the GEI between IL1RN variants and childhood ETS exposures on asthma and early onset asthma, respectively, adjusting for population admixture and other covariates. (3) Results: Whereas the rare genotypes of IL1RN SNPs (e.g., GG in SNP rs2234678) were associated with decreased risk for asthma among those without ETS exposure (odds ratio OR = 0.215, p = 0.021), they are associated with increased risk for early onset asthma among those with childhood ETS (OR = 4.467, p = 0.021). (4) Conclusions: We identified a GEI between polymorphisms of IL1RN and childhood ETS exposure in asthma. Analysis of GEI indicated that childhood ETS exposure disrupted the protective effect of some haplotypes/genotypes of IL1RN for asthma and turned them into high-risk polymorphisms for early onset asthma. View Full-Text
Keywords: gene and environment interaction; environmental tobacco smoke; IL1RN variants; early onset asthma; SNP genotypes; risk haplotypes; case-control association study; population admixture; ancestral informative markers; inflammation gene and environment interaction; environmental tobacco smoke; IL1RN variants; early onset asthma; SNP genotypes; risk haplotypes; case-control association study; population admixture; ancestral informative markers; inflammation
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Shao, Y.; Zhang, Y.; Liu, M.; Fernandez-Beros, M.-E.; Qian, M.; Reibman, J. Gene-Environment Interaction between the IL1RN Variants and Childhood Environmental Tobacco Smoke Exposure in Asthma Risk. Int. J. Environ. Res. Public Health 2020, 17, 2036.

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