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Article

The Effect of Ultraviolet B Irradiation Compared with Oral Vitamin D Supplementation on the Well-being of Nursing Home Residents with Dementia: A Randomized Controlled Trial

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Department of Public Health and Primary Care, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands
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Woonzorgcentra Haaglanden, Polanenhof 497, 2548 MP Den Haag, The Netherlands
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Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(5), 1684; https://doi.org/10.3390/ijerph17051684
Received: 23 December 2019 / Revised: 21 February 2020 / Accepted: 28 February 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Sun Exposure and Vitamin D for Public Health)
There are indications that ultraviolet B (UVB) exposure has beneficial effects on well-being through mechanisms other than vitamin D synthesis alone. We conducted a randomized controlled multicenter trial to compare the effects of UVB light and vitamin D supplementation (VD) in terms of the well-being of nursing home residents with dementia. Participants were randomly assigned to the intervention group (UVB group, n = 41; half-body UVB irradiation, twice weekly over 6 months, with 1 standard erythema dose (SED)) or to the control group (VD group, n = 37; 5600 International units (IU) cholecalciferol supplementation once a week). The main outcome was well-being, measured by the Cohen-Mansfield Agitation Inventory (CMAI) and the Cornell scale for depression in dementia at 0, 3, and 6 months. Secondary outcomes were QUALIDEM quality of life domains and biochemical parameters of bone homeostasis. Intention-to-treat analysis with linear mixed modeling showed no significant between-group differences on agitation (p = 0.431) or depressive symptoms (p = 0.982). At six months, the UVB group showed less restless/tense behavior compared to the VD group (mean difference of the mean change scores 2.2, 95% CI 0.8 to 3.6; p = 0.003 for group x time interaction) and lower serum 25(OH)D3 concentration (estimated mean difference - 21.9, 95% CI −32.6 to −11.2; p = 0.003 for group difference). The exposure of nursing home residents with dementia to UVB light showed no positive benefits in terms of wellbeing. UVB treatment may have a positive effect on the restless/tense behavior characteristic of advanced dementia but more research is needed to confirm this finding. View Full-Text
Keywords: UVB irradiation; vitamin D supplementation; well-being; quality of life; nursing home residents UVB irradiation; vitamin D supplementation; well-being; quality of life; nursing home residents
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MDPI and ACS Style

Veleva, B.I.; Caljouw, M.A.A.; van der Steen, J.T.; Mertens, B.J.A.; Chel, V.G.M.; Numans, M.E. The Effect of Ultraviolet B Irradiation Compared with Oral Vitamin D Supplementation on the Well-being of Nursing Home Residents with Dementia: A Randomized Controlled Trial. Int. J. Environ. Res. Public Health 2020, 17, 1684. https://doi.org/10.3390/ijerph17051684

AMA Style

Veleva BI, Caljouw MAA, van der Steen JT, Mertens BJA, Chel VGM, Numans ME. The Effect of Ultraviolet B Irradiation Compared with Oral Vitamin D Supplementation on the Well-being of Nursing Home Residents with Dementia: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health. 2020; 17(5):1684. https://doi.org/10.3390/ijerph17051684

Chicago/Turabian Style

Veleva, Bistra I., Monique A.A. Caljouw, Jenny T. van der Steen, Bart J.A. Mertens, Victor G.M. Chel, and Mattijs E. Numans 2020. "The Effect of Ultraviolet B Irradiation Compared with Oral Vitamin D Supplementation on the Well-being of Nursing Home Residents with Dementia: A Randomized Controlled Trial" International Journal of Environmental Research and Public Health 17, no. 5: 1684. https://doi.org/10.3390/ijerph17051684

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