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Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study

Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
Public Health Department, University of Oviedo, 33011 Oviedo, Spain
Occupational Risk Prevention Service, Hospital Central University of Asturias, Public Health Service of the Principado of Asturias (SESPA), 33006 Oviedo, Spain
Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, 21071 Huelva, Spain
Faculty of Nursing, University of Cantabria—IDIVAL, 39008 Santander, Spain
ISGlobal, 08903 Barcelona, Spain
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain
Department of Pathology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Hematology, Institut Català d’ Oncologia (IDIBELL), Universitat de Barcelona, L’ Hospitalet de Llobregat, 08908 Barcelona, Spain
Faculty of Medicine, University of Cantabria—IDIVAL, 39011 Santander, Spain
Hematology, Hospital del Mar, 08003 Barcelona, Spain
Hematopathology Unit/Hemato-Oncology Department, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08001 Barcelona, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28001 Madrid, Spain
Department of Preventive Medicine and Public Health, University of Granada, 18071 Granada, Spain
Instituto de Investigación Biosanitaria de Granada, Servicio Andaluz de Salud, Universidad de Granada, 18012 Granada, Spain
Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), 17007 Girona, Spain
Hospital del Mar Medical Research Institute (IMIM), 08001 Barcelona, Spain
Department of Health of Madrid, Epidemiology Section, Public Health Division, 28035 Madrid, Spain
National Center for Epidemiology, Carlos III Institute of Health, 28001 Madrid, Spain
Instituto de Investigación Sanitaria (IIS) de Hierro, 28220 Majadahonda, Spain
Sexual and Reproductive Health, PATH, Seattle, WA 98121, USA
IUOPA Medicine Department, University of Oviedo, 33003 Oviedo, Spain
Institute of Health Research of the Principality of Asturias-Foundation for Biosanitary Research of Asturias (ISPA-FINBA), 33003 Oviedo, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this article.
Int. J. Environ. Res. Public Health 2020, 17(14), 5174;
Received: 2 June 2020 / Revised: 29 June 2020 / Accepted: 5 July 2020 / Published: 17 July 2020
(This article belongs to the Special Issue Prevention of Occupational Risks)
We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010–2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances. View Full-Text
Keywords: pesticides; job-exposure matrix; chronic lymphocytic leukemia; occupational exposure pesticides; job-exposure matrix; chronic lymphocytic leukemia; occupational exposure
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MDPI and ACS Style

Benavente, Y.; Costas, L.; Rodríguez-Suarez, M.M.; Alguacil, J.; Santibáñez, M.; Vila, J.; Robles, C.; Alonso, E.; de la Banda, E.; Gonzalez-Barca, E.; Dierssen-Sotos, T.; Gimeno Vazquez, E.; Aymerich, M.; Campo, E.; Jiménez-Moleón, J.J.; Marcos-Gragera, R.; Castaño-Vinyals, G.; Aragonés, N.; Pollan, M.; de Sanjose, S.; Kogevinas, M.; Tardón, A.; Casabonne, D. Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study. Int. J. Environ. Res. Public Health 2020, 17, 5174.

AMA Style

Benavente Y, Costas L, Rodríguez-Suarez MM, Alguacil J, Santibáñez M, Vila J, Robles C, Alonso E, de la Banda E, Gonzalez-Barca E, Dierssen-Sotos T, Gimeno Vazquez E, Aymerich M, Campo E, Jiménez-Moleón JJ, Marcos-Gragera R, Castaño-Vinyals G, Aragonés N, Pollan M, de Sanjose S, Kogevinas M, Tardón A, Casabonne D. Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study. International Journal of Environmental Research and Public Health. 2020; 17(14):5174.

Chicago/Turabian Style

Benavente, Yolanda, Laura Costas, Marta M. Rodríguez-Suarez, Juan Alguacil, Miguel Santibáñez, Javier Vila, Claudia Robles, Esther Alonso, Esmeralda de la Banda, Eva Gonzalez-Barca, Trinidad Dierssen-Sotos, Eva Gimeno Vazquez, Marta Aymerich, Elias Campo, José J. Jiménez-Moleón, Rafael Marcos-Gragera, Gemma Castaño-Vinyals, Nuria Aragonés, Marina Pollan, Silvia de Sanjose, Manolis Kogevinas, Adonina Tardón, and Delphine Casabonne. 2020. "Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study" International Journal of Environmental Research and Public Health 17, no. 14: 5174.

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