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Article

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

1
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
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Department of Ophthalmology, Taichung Tzu Chi Hospital, Taichung 40201, Taiwan
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Department of Otolaryngology–Head and Neck Surgery, Tri-Service General Hospital, Taipei 11221, Taiwan
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Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 20402, Taiwan
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Department of Chinese Medicine, Chang Gung University, Taoyuan City 33302, Taiwan
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Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 50093, Taiwan
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Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 33305, Taiwan
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Department of Medicine, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan
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Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 33305, Taiwan
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Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan 717, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2019, 16(22), 4456; https://doi.org/10.3390/ijerph16224456
Received: 22 September 2019 / Revised: 12 November 2019 / Accepted: 12 November 2019 / Published: 13 November 2019
This study investigates the development of glaucoma in subjects with surgery-indicated chronic rhinosinusitis (CRS) by the use of the National Health Insurance Research Database in Taiwan. Individuals that received the functional endoscopic sinus surgery (FESS) with a diagnostic code of CRS were regarded as surgery-indicated CRS and enrolled in the study group. Four non-CRS patients were age- and gender-matched to each patient in the study group. The exclusion criteria included legal blindness, ocular tumor, history of eyeball removal, and previous glaucoma. The outcome was regarded as the development of glaucoma, and conditional logistic regression was used for the statistical analysis, which involved multiple potential risk factors in the multivariate model. A total of 6506 patients with surgery-indicated CRS that received FESS and another 26,024 non-CRS individuals were enrolled after exclusion. The age and gender distributions were identical between the two groups due to matching. There were 108 and 294 glaucoma events in the study group and control group, respectively, during the follow-up period, and the study group had a significantly higher adjusted hazard ratio (1.291, 95% confidential interval: 1.031–1.615). The cumulative probability analysis also revealed a correlation between the occurrence of glaucoma and the CRS disease interval. In the subgroup analysis, the chance of developing open-angle glaucoma and normal-tension glaucoma was significantly higher in the study group than in the control group. In conclusion, the existence of surgery-indicated CRS is a significant risk factor for the development of glaucoma, which correlated with the disease interval. View Full-Text
Keywords: chronic rhinosinusitis; functional endoscopic sinus surgery; glaucoma; population-based chronic rhinosinusitis; functional endoscopic sinus surgery; glaucoma; population-based
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MDPI and ACS Style

Chau, S.-F.; Wu, P.-H.; Sun, C.-C.; Huang, J.-Y.; Nien, C.-W.; Yang, S.-F.; Chou, M.-C.; Lu, P.-T.; Chen, H.-C.; Lee, C.-Y. The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study. Int. J. Environ. Res. Public Health 2019, 16, 4456. https://doi.org/10.3390/ijerph16224456

AMA Style

Chau S-F, Wu P-H, Sun C-C, Huang J-Y, Nien C-W, Yang S-F, Chou M-C, Lu P-T, Chen H-C, Lee C-Y. The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study. International Journal of Environmental Research and Public Health. 2019; 16(22):4456. https://doi.org/10.3390/ijerph16224456

Chicago/Turabian Style

Chau, Siu-Fung, Pei-Hsuan Wu, Chi-Chin Sun, Jing-Yang Huang, Chan-Wei Nien, Shun-Fa Yang, Ming-Chih Chou, Pei-Ting Lu, Hung-Chi Chen, and Chia-Yi Lee. 2019. "The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study" International Journal of Environmental Research and Public Health 16, no. 22: 4456. https://doi.org/10.3390/ijerph16224456

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