Next Article in Journal
Analysis of the Effect of Backpack Design with Reduced Load Moment Arm on Spinal Alignment
Previous Article in Journal
Prediction of Indoor Air Temperature Using Weather Data and Simple Building Descriptors
Open AccessArticle

Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels in Older Adults: A Population-Based Cohort Study

1
Department of Preventive Medicine, Colleague of Medicine, Seoul National University, Seoul 08826, Korea
2
Institute of Health and Environment, School of Public Health, Seoul National University, Seoul 08826, Korea
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(22), 4350; https://doi.org/10.3390/ijerph16224350
Received: 4 October 2019 / Revised: 1 November 2019 / Accepted: 3 November 2019 / Published: 7 November 2019
Background: Despite a potential link between immunoglobulin E (IgE) levels and cardiovascular disease, the effect of elevated total IgE levels on long-term mortality risk remains unclear. We prospectively investigated the association between total serum IgE levels and all-cause and cardiovascular mortality in US adults. Methods: We analyzed data from the 2005–2006 National Health and Nutrition Examination Survey (NHANES) and the NHANES (2005–2006) Linked Mortality Public File. The 2005–2006 NHANES data of 1496 older adults aged ≥50 years and who underwent a serum total IgE antibody test in the initial survey were included. Results: After a median follow-up of 119 months, a significant association was observed between total serum IgE levels and cardiovascular mortality, with subjects with the highest total IgE exhibiting a 3.19-fold (HR = 3.19; 95% confidence interval: 1.71–5.96) increase in the risk of cardiovascular mortality compared with those with the lowest total IgE (≤16.80 kU/L). Furthermore, the mortality rate increased with an increase in total IgE levels, regardless of baseline history of cardiovascular diseases (e.g., myocardial infarction, stroke, and noninvasively diagnosed large-vessel peripheral arterial disease). Conclusions: This finding suggests that the elevation of IgE levels may be a risk factor for increased cardiovascular mortality. View Full-Text
Keywords: immunoglobulin E; premature death; cause of death; cardiovascular disease; population-based cohort immunoglobulin E; premature death; cause of death; cardiovascular disease; population-based cohort
Show Figures

Figure 1

MDPI and ACS Style

Min, K.-B.; Min, J.-Y. Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels in Older Adults: A Population-Based Cohort Study. Int. J. Environ. Res. Public Health 2019, 16, 4350.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop