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Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential

1
Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
2
VitroLive Fertility Clinic in Szczecin, 70-483 Szczecin, Poland
3
Department of Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland
4
Healthcare Center Nowe Orlowo, 81-525 Gdynia, Poland
5
Invicta Fertility Clinic, 80-850 Gdansk, Poland
6
Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(11), 2004; https://doi.org/10.3390/ijerph16112004
Received: 13 May 2019 / Revised: 29 May 2019 / Accepted: 3 June 2019 / Published: 5 June 2019
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
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Abstract

Because the assessment of sperm DNA fragmentation (SDF) plays a key role in male fertility, our study was designed to find the relationships between SDF and standard semen parameters. The receiver operating characteristic (ROC) curve showed that 18% SDF is a prognostic parameter for discriminating between men with normal and abnormal standard semen parameters (n = 667). Men with > 18% SDF had significantly lower quality semen, a higher prevalence of abnormal semen characteristics, and a higher odds ratio for abnormal semen parameters compared to men with ≤ 18% SDF. An ROC analysis provided predictive values for age and semen parameters to distinguish between men with SDF > 18% and men with ≤ 18% SDF. SDF was positively correlated with male age and teratozoospermia index but negatively with sperm concentration, total number of spermatozoa, sperm morphology, progressive motility, and vitality. Our study shows that 18% SDF has a predictive value for distinguishing between men with normal and abnormal semen characteristics. Men with >18% SDF have a higher risk for abnormal semen parameters, while age and obtained semen parameters have a predictive value for SDF. There is a relationship between SDF and conventional sperm characteristics, and thus, SDF can be incorporated into male fertility assessment. View Full-Text
Keywords: semen analysis; male fertility potential; sperm DNA fragmentation semen analysis; male fertility potential; sperm DNA fragmentation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gill, K.; Jakubik, J.; Rosiak-Gill, A.; Kups, M.; Lukaszuk, M.; Kurpisz, M.; Fraczek, M.; Piasecka, M. Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential. Int. J. Environ. Res. Public Health 2019, 16, 2004.

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