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Int. J. Environ. Res. Public Health 2019, 16(1), 148; https://doi.org/10.3390/ijerph16010148

The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice

1
Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Kingdom of Bahrain
2
Nanomedicine Research Unite, Princess Al—Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 329, Kingdom of Bahrain
3
Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
4
Department of Drug Sciences, University of Catania, 95125 Catania, Italy
*
Author to whom correspondence should be addressed.
Received: 20 November 2018 / Revised: 23 December 2018 / Accepted: 4 January 2019 / Published: 8 January 2019
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Abstract

Silver Nanoparticles (AgNPs), an epitome of nanotechnology, appear in everyday products such as water filters, printer ink, toothpaste, food packaging and cosmetics mostly due to their bactericidal properties. Given this high level of public exposure, the safety of AgNPs has never been fully established. The unsafe use of AgNPs could pose a real threat, not only to public health but also to economic growth in many industries. In this paper, we tested the effect of AgNPs on memory, learning, social behaviour and motor function of BALB/C mice. Outcomes of the present study suggested an impairment of these functions in AgNPs treated groups. Overall, obtained data support the evidence that the systemic exposure to AgNPs may result in alteration of the cerebral cognition and warrants further consideration on the impact of the AgNPs on human health with respect to their potential neurotoxicity. View Full-Text
Keywords: silver nanoparticles; BALB/C mice; behavioural testing; nanotoxicity; learning; memory silver nanoparticles; BALB/C mice; behavioural testing; nanotoxicity; learning; memory
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Greish, K.; Alqahtani, A.A.; Alotaibi, A.F.; Abdulla, A.M.; Bukelly, A.T.; Alsobyani, F.M.; Alharbi, G.H.; Alkiyumi, I.S.; Aldawish, M.M.; Alshahrani, T.F.; Pittalà, V.; Taurin, S.; Kamal, A. The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice. Int. J. Environ. Res. Public Health 2019, 16, 148.

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