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Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study

Institute of Global Health-Faculty of Medicine, Chemin de Mines 9, 1202 Geneva, Switzerland
Community Psychiatric Service, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland
Gynecology Division, Department of Obstetrics and Gynecology, Geneva University Hospitals, Boulevard de la Cluse 30, 1205 Geneva, Switzerland
Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland
Geneva Foundation for Medical Education and Research, Route de Ferney 150, 1211 Geneva 2, Switzerland
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(7), 1447;
Received: 31 May 2018 / Revised: 2 July 2018 / Accepted: 5 July 2018 / Published: 9 July 2018
(This article belongs to the Special Issue Vaccination and Health Outcomes)
Background: The human papillomavirus (HPV) vaccination program for young girls aged 11–26 years was introduced in Switzerland in 2008. The objective of this study was to evaluate the prevalence of high- and low-risk HPV in a population of undergraduate students using self-sampling for monitoring the HPV vaccination program’s effect. Methods: Undergraduate women aged between 18–31 years, attending the Medical School and University of Applied Sciences in Geneva, were invited to participate in the study. Included women were asked to perform vaginal self-sampling for HPV testing using a dry cotton swab. Results: A total of 409 students participated in the study—aged 18–31 years—of which 69% of the participants were vaccinated with Gardasil HPV vaccine and 31% did not received the vaccine. About HPV prevalence, 7.2% of unvaccinated women were HPV 16 or 18 positive, while 1.1% of vaccinated women were infected by HPV 16 or 18 (p < 0.01). Prevalence of HPV 6 and 11 was 8.3% in non-vaccinated women versus 2.1% in vaccinated women (p < 0.02). We observed no cross-protection for the other HPV genotypes of a low- and high-risk strain. Conclusions: Prevalence of HPV 6/11/16/18 was lower in vaccinated women versus unvaccinated women. Continued assessment of HPV vaccine effectiveness in real population is needed. View Full-Text
Keywords: HPV; self-sampling; vaccination HPV; self-sampling; vaccination
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Jeannot, E.; Viviano, M.; De Pree, C.; Amadane, M.; Kabengele, E.; Vassilakos, P.; Petignat, P. Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study. Int. J. Environ. Res. Public Health 2018, 15, 1447.

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