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Open AccessArticle

Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study

1
Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei 11217, Taiwan
2
Department of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
3
Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
4
Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan
5
College of Medicine, China Medical University, Taichung 404, Taiwan
6
Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan
7
Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 404, Taiwan
8
Department of Bioinformatics and Medical Engineering, Asia University, Taichung 413, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2018, 15(4), 587; https://doi.org/10.3390/ijerph15040587
Received: 6 February 2018 / Revised: 22 March 2018 / Accepted: 22 March 2018 / Published: 25 March 2018
Background: Few studies have investigated the longitudinal association between cervical spondylosis (CS) and migraine by using a nationwide population-based database. Methods: We conducted a retrospective cohort study from 2000 to 2011 identifying 27,930 cases of cervical spondylosis and 111,720 control subjects (those without cervical spondylosis) from a single database. The subjects were frequency-matched on the basis of sex, age, and diagnosis date. The non- cervical spondylosis cohort was four times the size of the cervical spondylosis cohort. To quantify the effects of cervical spondylosis on the risk of migraine, univariate and multivariate Cox proportional hazard regression analyses were used to calculate the hazard ratio (HR), and 95% confidence interval (CI). Results: After a 10-year follow-up controlling for potential confounding factors, overall migraine incidence was higher in the cervical spondylosis cohort than in the non-cervical spondylosis cohort (5.16 and 2.09 per 1000 people per year, respectively; crude hazard ratio = 2.48, 95% confidence interval = 2.28–2.69), with an adjusted hazard ratio of 2.03 (95% confidence interval = 1.86–2.22) after accounting for sex, age, comorbidities, and medication. Individuals with myelopathy in the cervical spondylosis cohort had a 2.19 times (95% confidence interval = 1.80–2.66) higher incidence of migraine when compared than did those in the non- cervical spondylosis cohort. Conclusions: Individuals with cervical spondylosis exhibited a higher risk of migraine than those without cervical spondylosis. The migraine incidence rate was even higher among individuals with cervical spondylotic myelopathy. View Full-Text
Keywords: cervical spondylosis; migraine; retrospective cohort study; population-based cervical spondylosis; migraine; retrospective cohort study; population-based
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Lin, W.-S.; Huang, T.-F.; Chuang, T.-Y.; Lin, C.-L.; Kao, C.-H. Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study. Int. J. Environ. Res. Public Health 2018, 15, 587.

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