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Curcumin, Cardiometabolic Health and Dementia

by 1,* and 2
1
Department of Food and Nutrition/Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea
2
School of Pharmacy and Medical Sciences, University of South Australia, General Post Office Box 2471, Adelaide, SA 5001, Australia
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(10), 2093; https://doi.org/10.3390/ijerph15102093
Received: 19 August 2018 / Revised: 15 September 2018 / Accepted: 20 September 2018 / Published: 24 September 2018
Current research indicates curcumin [diferuloylmethane; a polyphenolic compound isolated from the rhizomes of the dietary spice turmeric (Curcuma longa)] exerts a beneficial effect on health which may be partly attributable to its anti-oxidative and anti-inflammatory properties. The aim of this review is to examine potential mechanisms of the actions of curcumin in both animal and human studies. Curcumin modulates relevant molecular target pathways to improve glucose and lipid metabolism, suppress inflammation, stimulate antioxidant enzymes, facilitate insulin signalling and reduce gut permeability. Curcumin also inhibits Aβ and tau accumulation in animal models and enhances mitochondria and synaptic function. In conclusion, in high-dose animal studies and in vitro, curcumin exerts a potential beneficial effect on cardiometabolic disease. However, human studies are relatively unconvincing. More intervention studies should be conducted with the new curcumin formulation with improved oral bioavailability. View Full-Text
Keywords: Curcumin; glucose; insulin resistance; inflammation; type 2 diabetes Curcumin; glucose; insulin resistance; inflammation; type 2 diabetes
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MDPI and ACS Style

Kim, Y.; Clifton, P. Curcumin, Cardiometabolic Health and Dementia. Int. J. Environ. Res. Public Health 2018, 15, 2093. https://doi.org/10.3390/ijerph15102093

AMA Style

Kim Y, Clifton P. Curcumin, Cardiometabolic Health and Dementia. International Journal of Environmental Research and Public Health. 2018; 15(10):2093. https://doi.org/10.3390/ijerph15102093

Chicago/Turabian Style

Kim, Yoona; Clifton, Peter. 2018. "Curcumin, Cardiometabolic Health and Dementia" Int. J. Environ. Res. Public Health 15, no. 10: 2093. https://doi.org/10.3390/ijerph15102093

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