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Int. J. Environ. Res. Public Health 2018, 15(1), 102;

Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure
Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 03760, Korea
Department of Occupational and Environmental Medicine, School of Medicine, Inha University, Incheon 22212, Korea
Department of Pediatrics, College of Medicine, Korea University, Seoul 02841, Korea
Taean Environmental Health Center, Taean 32144, Korea
Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 02841, Korea
Department of Occupational and Environmental Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 44033, Korea
Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 31116, Korea
Author to whom correspondence should be addressed.
Received: 3 December 2017 / Accepted: 3 January 2018 / Published: 9 January 2018


Few birth cohort studies have examined the role of traffic-related air pollution (TRAP) in the development of infantile atopic dermatitis (AD), but none have investigated the role of preventive factors such as green spaces. The aim of this study was to investigate whether exposure to nitrogen dioxide (NO2) and particulate matter with an aerodynamic diameter of <10 μm (PM10) during pregnancy is associated with increased risk of development of AD in 6-month-old children and also to examine how this association changes with residential green space. This study used prospective data from 659 participants of the Mothers and Children’s Environmental Health study. Subjects were geocoded to their residential addresses and matched with air pollution data modeled using land-use regression. Information on infantile AD was obtained by using a questionnaire administered to the parents or guardians of the children. The association between infantile AD and exposure to NO2 and PM10 was determined using logistic regression models. We assessed the effects of residential green spaces using stratified analyses and by entering product terms into the logistic regression models. The risk of infantile AD significantly increased with an increase in air pollution exposure during the first trimester of pregnancy. The adjusted odds ratio (OR) and 95% confidence interval (CI) were 1.219 (1.023–1.452) per 10 μg/m3 increase in PM10 and 1.353 (1.027–1.782) per 10 ppb increase in NO2. An increase in the green space within 200 m of residence was associated with a decreased risk of AD (OR = 0.996, 95% CI: 0.993–0.999). The stratified analysis of residential green space revealed stronger associations between infantile AD and PM10 and NO2 exposure during the first trimester in the areas in the lower tertiles of green space. This study indicated that exposure to TRAP during the first trimester of pregnancy is associated with infantile AD. Less residential green space may intensify the association between TRAP exposure and infantile AD.
child health; atopic dermatitis; greenness; traffic-related air pollution; particulate matter; birth cohort

1. Introduction

Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects as many as 10–30% of children [1,2] with a typical onset during infancy. The prevalence of AD appears to have increased worldwide in recent decades [1,3]. In South Korea, the prevalence of AD in children aged 6–7 years was 5.7% and 11.2% in 2000 and 2010, respectively [4]. Despite many attempts to identify the causative factors of AD in children, they remain unknown. Although genetic factors and atopic sensitization are considered major determinants of prognosis [5], the growing incidence rate in recent years is most likely associated with environmental factors [6].
Several epidemiological studies have reported that exposure to ambient air pollutants increases the risk of AD or exacerbates AD symptoms in children [7,8]. Increasingly, exposure to air pollution during pregnancy is being considered a potential cause of AD. However, studies regarding prenatal exposure to air pollution and the development of AD are limited [9,10,11,12,13,14,15,16,17,18]. Most of these studies reported that exposures to ambient air pollutants during pregnancy increase the risk of AD in childhood. These studies differ considerably with regard to exposure assessment and outcome definitions, including the age of children. Other studies have shown no association between ambient air pollutants during pregnancy and AD in childhood [17,18].
Access to green space around homes is inversely associated with the risk of AD in children [19,20]. Green spaces have also been associated with better mental health and improved cardiovascular health in the general adult population [21,22]. Some studies have reported that residing in or near green spaces unfavorably influences allergy health outcomes in children [23,24,25]. Recent studies have suggested that the health benefits for overweight and obese children may depend on the type of green space [26], and that greenness has beneficial effects on adverse pregnancy outcomes such as low birth weight and preterm birth [27].
Inconsistent associations between air pollution exposure during pregnancy and AD have prompted further study of the relationship between air pollution, green space, and infantile AD. Although previous studies have found that infantile AD may be related to air pollution during pregnancy and that green spaces may mitigate risk, all those studies analyzed the effects of air pollution and residential greenness separately [11,13,20]. This is the first cohort study to investigate the relationship between exposure to traffic-related air pollution (TRAP), consisting of particulate matter with an aerodynamic diameter of ≤10 µm (PM10) and nitrogen dioxide (NO2), during pregnancy, with green spaces and the development of AD in children aged 6 months.
In this study, we sought to investigate whether exposure to PM10 and NO2 during different periods of pregnancy is associated with increased risk of infantile AD. Furthermore, in the stratified analysis, we investigated the combined effects of TRAP and greenness on the risk for infantile AD.

2. Materials and Methods

2.1. Study Population

This was a prospective birth cohort study conducted as a part of the Mothers and Children’s Environmental Health (MOCEH) study that included 1751 pregnant women and was performed from 2006 to 2010 in the Republic of Korea. After excluding subjects that were lost to follow-up, 1516 participants were eligible for enrollment in the study. The MOCEH has been previously described in detail [28]. Exposure levels to TRAP were estimated for 1471 women who provided an exact residential address. We excluded 85 children with a gestational age <37 weeks or birth weight <2500 g. Of the remaining 1386 participants, 727 were excluded for the following missing information: AD status at 6 months of age (n = 390), maternal body mass index (BMI; n = 17), family income (n = 36), educational status (n = 11), parental allergy history (n = 4), parity (n = 116), exposure to second-hand smoke (n = 1), type of birth (n = 149), breastfeeding (n = 1), and temperature (n = 2). The final study population consisted of 659 pregnant women and their babies. The characteristics of the excluded participants did not differ significantly from those of the study population except for the presence of pets (Table S1). The participants who enrolled in this study provided written informed consent before participation, and the study was approved by the institutional review boards (EGCT 117-4) of Ewha Woman’s University, Dankook University Hospital, and Ulsan University Hospital.

2.2. Exposure to TRAP

Exposure to TRAP was assessed based on geocoded residential addresses. The concentrations of PM10 and NO2 at the participant’s residential address were estimated using land-use regression (LUR) models following a previously described standardized method [29]. In brief, we modeled TRAP concentrations using a regulatory monitoring network and the ambient concentrations of PM10 and NO2 in the study area. The air pollutants were measured at 37 regulatory monitoring sites of the Korean Ministry of Environment, using centrally and locally available geographic variables as potential predictors. Predictor variables, such as traffic indicators, surrounding land usage, topography, and spatial trends, were derived from a geographic information system (GIS) (ArcGIS version 9.3, ESRI, Redlands, CA, USA). Multiple linear regression models were built using a supervised forward stepwise procedure. The predictor variables that were left in the final LUR model included the length of all roads, traffic intensity on the nearest road, total heavy-duty traffic loads on all roads, and variables representing spatial trends. To specify the uncertainty of air pollution exposure, we calculated the adjusted R2, the leave-one-out-cross-validation (LOOCV) R2, and the root mean squared error (RMSE) between the predicted and measured concentrations. The model adjusted R2 and the LOOCV R2 of the NO2 models were 0.79 and 0.73, respectively. For PM10 models, the adjusted R2 and the LOOCV R2 were 0.69 and 0.60, respectively. The RMSE was 0.005 ppm for NO2 and 3.14 µg/m3 for PM10, which suggested that the predicted values fitted well with the measured values, as also reported in previous study [30].
The mean PM10 and NO2 exposure levels were computed by using each participant’s gestational age and birth date. The mean values were first generated for each day, and the daily mean values were then averaged for each pregnant woman over different periods of the pregnancy as follows: 0 to 12 weeks gestation (first trimester), 13 to 28 weeks gestation (second trimester), 29 to 42 weeks gestation (third trimester), and 0 to 42 weeks gestation (entire pregnancy).

2.3. Assessment of Green Spaces

To determine green spaces, we used the land cover classification maps (1:25,000) of the Korean Ministry of Environment that detail land cover and use across Korea. These are thematic maps made by using Landsat image data from the National Aeronautics and Space Administration and Korean Arirang satellite images. These spatial information databases depict the surface of the earth based on certain scientific criteria and then color index the area with homogeneous characteristics for display in the form of a map. The maps developed by the Environmental Spatial Information Service Center of the Ministry of Environment are largely divided into urbanized areas including parks, agricultural areas, forest areas, grasslands, wetlands, open areas, and coastal areas. Using the GIS tool (ArcGIS 9.3), we extracted the maps of parks, forest areas, and grasslands. These maps were used to calculate the amount of green space within different buffer sizes (100 m, 200 m, 300 m, and 500 m) around the maternal residential address [27,31].

2.4. Health Outcome

Information on doctor-diagnosed infantile AD at the age of 6 months was obtained from the Korean version of the International Study on Allergies and Asthma in Childhood (ISAAC) that included a standardized questionnaire according to an enriched version of the ISAAC standardized protocol. The occurrence of infantile AD was defined as an affirmative answer to the question, “Has a doctor told you that your son/daughter has atopic dermatitis?”.

2.5. Statistical Analysis

We used the chi-square test and t-test to compare the values and frequencies of the baseline characteristics according to the child’s AD status. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) to assess the relationship between AD and TRAP (PM10 and NO2) or levels of green space. These models were adjusted for the mother’s age (years), body mass index (BMI), gestational age (weeks), parity (0, 1, or ≥2), infant sex (male vs. female), exposure to environmental tobacco smoke (yes vs. no), educational level (more than university vs. less than university), parental history of allergy (yes vs. no), family income (<$2000, $2000–$4000, or >$4000), presence of pets (yes vs. no), residential mobility during pregnancy (yes vs. no), season of birth (winter vs. other seasons), breastfeeding (exclusive breastfeeding vs. exclusive formula or mixed feeding), type of birth (cesarean vs. vaginal), temperature, and humidity. To assess the combined effect of TRAP and green space, we conducted a stratified analysis in which we examined the association between exposure to PM10 and NO2 during different windows of pregnancy and childhood AD according to the level of green space. We investigated the AD risk resulting from PM10 and NO2 exposure stratified by tertile of green space. All analyses were performed with Stata 13 (Stata Corporation, College Station, TX, USA). The significance level was set at p < 0.05.

3. Results

Table 1 summarizes the demographic characteristics of the participants with and without AD. Most of the mothers were highly educated (72.7% were university or college graduates), were not exposed to pets (97.4%) during pregnancy, and belonged to a higher socioeconomic status based on an income of ≥$2000/month. Generally, the maternal and infant characteristics different between children with and without AD at 6 months. However, average birth weight and maternal BMI were different between infants with and without AD. Parity and education level were significantly higher among mothers of children with AD. Our study included a fairly large number of AD cases in areas with less green space (Figure 1).
Table 2 summarizes the data for maternal exposure to air pollutants during different periods of pregnancy. The mean exposures during pregnancy were 53.60 μg/m3 for PM10 and 24.69 ppb for NO2. The correlation of the subjects’ trimester-specific PM10 and NO2 mean concentrations varied across trimesters. The concentration of the first trimester (Pearson’s correlation coefficient, r = 0.51) and the third (r = 0.37) trimester were moderately correlated. Mean concentrations for the whole pregnancy were highly correlated with trimester-specific mean NO2 concentration (r = 0.89–0.95) and moderately correlated with mean PM10 concentration (r = 0.37–0.73). The mean size of the green space within a 200-m buffer of the residences was 62.00 m2. There was a negative correlation between the mean level of green space (200-m buffer) and the PM10 and NO2 concentrations (r = −0.12 and r = −0.45, respectively; p < 0.001).
The association between AD at 6 months of age and exposure to air pollutants in different trimesters is shown in Table 3. We found that the association was significant only for exposure to PM10 and NO2 during the first trimester of pregnancy. The adjusted OR (95% CI) was 1.219 (1.023–1.452) per 10 μg/m3 increase in PM10 and 1.353 (1.027–1.782) per 10 ppb increase in NO2. Furthermore, an increase in green space area within a 200-m buffer around the home address was associated with a statistically significant decrease in AD risk. The adjusted OR (95% CI) was 0.996 (0.993–0.999). Risk estimates were consistent for a 300 m-buffer size but not significant for the 100-m and 500-m buffer sizes. The unadjusted associations were consistent with the adjusted associations, although somewhat higher ORs were observed for the adjusted associations. The unadjusted association between PM10 exposure in the third trimester and AD showed some beneficial effect, but this association remained insignificant in the adjusted model.
We found that the risk of AD during the first trimester was significant at the lower tertiles of green space within the 200-m buffer. The adjusted OR (95% CI) was 1.581 (1.162–2.152) per 10 μg/m3 increase in PM10 and 1.632 (1.050–2.538) per 10 ppb increase in NO2 (Table 4). However, this association disappeared in the upper tertiles. The association between PM10 and infantile AD at low levels of green space (tertile 1) for the other buffer sizes (100 m, 300 m, and 500 m) were also significant, but the results were inconsistent for NO2 exposure.

4. Discussion

The results of this prospective cohort study provide evidence that maternal exposure to PM10 and NO2 during the first trimester of pregnancy increases infantile AD risk and that this risk is reduced in residential areas with sufficient green space.
Exposure to ambient pollutants during early pregnancy may be important for the development of AD. To date, few studies have reported the effect that TRAP exposure in specific trimesters has on the development of childhood AD [11,13,17]. Three recent cohort studies demonstrated associations between childhood AD and exposure to air pollution by trimester. One study in Taiwan reported that the risk of AD in infants at the age of 6 months was significantly associated with exposure to carbon monoxide, a proxy measure for TRAP, during the first trimester [11]. Another study in Spain found that the risk of AD in children during the first 12–18 months of age was associated with NO2 exposure during the second and third trimesters [17]. A third study in China observed that the highest risk of AD after exposure to NO2 during the first trimester occurred at 3–6 years of age [13]. Our findings are comparable to those of Huang et al. (2015) [11], who found that exposure to TRAP in the first trimester was a potential risk factor for the development of AD in early childhood. The skin structures of the fetus develop rapidly in the first trimester of pregnancy [32], making it a critical period where the fetus may be highly vulnerable to the harmful effects of air pollution [18,33]. One study suggested that infants may be indirectly affected before birth due to air pollution crossing the protective barrier of the placenta or due to a systemic effect on the health of the mother [34].
We found a stronger influence of TRAP on AD in children residing in areas with less green space, suggesting that AD might be affected by the amount of residential green space. A previous study showed that the amount of forest and agricultural land around homes was inversely associated with the risk of atopic sensitization in children [19], which is associated with the development of AD [35]. Although the exact mechanism of the preventive effect of green space on TRAP-related AD is not known, the environmental biodiversity hypothesis might provide a useful framework for identifying potential underlying mechanisms [36]. Environmental biodiversity has been proposed to contribute to human commensal microbiota, and the microbiota are increasingly understood to influence immune tolerance [37]. Commensal microorganisms on the skin have been shown to correlate with the levels of an inflammatory cytokine that plays a key role in immunologic tolerance (IL-10) [38]. Studies have shown that T-helper 2 chemokines are highly expressed in the skin of patients with AD [39,40] and there have been significant immunologic improvements in children with AD after short-term exposure to forest environments [20]. Maternal exposure to air pollution during pregnancy may alter immune competence in the offspring, thus increasing the risk of AD later in life [41]. Therefore, low green space exposure may exert a suppressive effect on immunologic mechanisms and may, in turn, contribute to the development of TRAP-related AD. However, we could not rule out the possibility of other mechanisms. For example, vegetation may reduce the adverse effect of air pollution on AD by filtering pollutants from the air and lowering ambient temperatures [42,43,44]. Moreover, the helpful effects of vegetation may be outweighed by the adverse effects of pollen [24]. Therefore, in our study, we could not exclude the possible effect of allergens on immunologic improvement.
The main strength of our study was its prospective design beginning in early pregnancy. This design minimized the uncertainty of random error in the covariates of interest. Another strength is the objective estimation of exposure to TRAP at the individual level with temporally adjusted LUR models to capture small-scale variability in pollution. We found an association between increased mean personal exposure to TRAP and the lack of green space surrounding the residential address using individual exposure modeling. However, this method could not estimate personal exposure influenced by maternal time-activity patterns [45]. Higher or lower personal exposures for women at work and away from their residences during pregnancy may have caused exposure misclassification. Also, this study relies on address at recruitment early in pregnancy to generate pollution measures. Those women who moved may have caused additional exposure misclassification mostly for the exposure later in the pregnancy, and this might explain why we find association in the first pregnancy period. Another limitation is that health data were obtained through questionnaires and could have been misclassified. Moreover, cases with missing data were excluded from the study. This may have affected the results due to the loss of information. However, we did not find significant differences between the participants included in this study and those excluded from the study (Table S1).

5. Conclusions

Prenatal exposure to TRAP, especially in the first trimester of pregnancy, and low residential green space are both associated with an increased risk of AD at 6 months of age. Exposure to less green space may intensify the effect of PM10 and NO2 exposure in developing childhood AD. Our findings support the hypothesis that childhood AD may originate in the fetus and may be triggered by TRAP. Our results indicate that strategies to reduce TRAP exposure and to expand green space (forest, parks, etc.) access for pregnant women during early gestation are needed to prevent childhood AD.

Supplementary Materials

The following are available online at, Table S1: Characteristics of study participants who were included or not included in the present study.


The authors would like to express their sincere thanks to MOCEH (Mothers and Children’s Environmental Health) project of the Ministry of Environment, Republic of Korea. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2-2016-1674-001-1).

Author Contributions

Yun-Chul Hong, Yangho Kim, Mina Ha and Eunhee Ha conceived and designed the experiments; Myeongjee Lee, Shinhee Ye, Jung-Hyun Kwon, Myung-Sook Park, Hwan-Cheol Kim and Jong-Han Leem performed the experiments and analyzed the data; Eunhee Ha, Dirga Kumar Lamichhane and Ji-Young Lee analyzed the data and wrote the paper. Yun-Chul Hong, Mina Ha and Eunhee Ha ultimately revised the paper.

Conflicts of Interest

The authors declare no conflict of interest.


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Figure 1. Green space and atopic dermatitis in children. The red filled circles indicate the children with atopic dermatitis; and the blue filled circles indicate the children without atopic dermatitis. The green color indicates green spaces.
Figure 1. Green space and atopic dermatitis in children. The red filled circles indicate the children with atopic dermatitis; and the blue filled circles indicate the children without atopic dermatitis. The green color indicates green spaces.
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Table 1. Characteristics of study participants.
Table 1. Characteristics of study participants.
CharacteristicsTotal (n = 659)Atopic Dermatitis at Age 6 Monthsp-Value 1
Yes (n = 168)No (n = 492)
Age (years), n (%)
 <30326 (49.5)88 (52.7)238 (48.4)0.567
 30–34268 (40.7)65 (38.9)203 (41.3)
 ≥3565 (9.8)14 (8.4)51 (10.3)
Education, n (%)
 <university180 (27.3)32 (19.2)148 (30.1)0.006
 ≥university479 (72.7)135 (80.8)344 (69.9)
Income per month, n (%)
 <$2000177 (26.9)48 (28.7)129 (26.2)0.591
$2000–4000354 (53.7)84 (50.3)270 (54.9)
 >$4000128 (19.4)35 (21.0)93 (18.9)
 Pre-pregnancy BMI 2, mean (SD)21.3 (2.9)20.9 (3.1)21.5 (2.8)0.025
Parity, n (%)
 0315 (47.8)92 (55.1)223 (45.3)0.029
 ≥1344 (52.2)75 (44.9)269 (54.7)
History of allergy, n (%)
 No470 (71.3)113 (67.7)357 (72.6)0.227
 Yes189 (28.7)54 (32.3)135 (27.4)
Exposure to SHS, n (%)
 No400 (60.7)106 (63.5)294 (59.8)0.395
 Yes259 (39.3)61 (36.5)198 (40.2)
Residential mobility, n (%)
 No575 (87.2)140 (83.8)435 (88.4)0.125
 Yes84 (12.8)27 (16.2)57 (11.6)
 Gestational age (weeks), mean (SD)39.0 (1.1)39.1 (1.1)39.0 (1.1)0.665
Type of birth, n (%)
 Vaginal birth425 (64.5)108 (64.7)317 (64.4)0.955
 Cesarean section234 (35.5)59 (35.3)175 (35.6)
Season of birth, n (%)
 Winter184 (27.9)43 (25.8)141 (28.7)0.469
 Others475 (72.1)124 (74.2)351 (71.3)
Presence of pets, n (%)
 No642 (97.4)162 (97.0)480 (97.6)0.696
 Yes17 (2.6)5 (3.0)12 (2.4)
Sex, n (%)
 Male358 (54.3)89 (53.3)269 (54.7)0.757
 Female301 (45.7)78 (46.7)223 (45.3)
 Birth weight (grams), mean (SD)3310 (374.4)3364 (393.7)3292 (366.2)0.030
Breastfeeding, n (%)
 Exclusive breast-feeding238 (36.1)67 (40.1)171 (34.8)0.212
 Exclusive formula or mixed feeding421 (63.9)100 (59.9)321 (65.2)
1 Two-sided χ2 test and t-test where appropriate. 2 Weight in kilograms/height in m2. Abbreviations: SD, standard deviation; SHS, secondhand smoke; BMI, body mass Index.
Table 2. Distributions of prenatal PM10/NO2 exposure, temperature, humidity, and greenness levels in residential areas of 6-month-old children.
Table 2. Distributions of prenatal PM10/NO2 exposure, temperature, humidity, and greenness levels in residential areas of 6-month-old children.
Exposure VariablesMean (SD)MinimumPercentilesMaximum
PM10 exposure (μg/m3)
 First trimester54.27 (12.49)21.47 44.38 53.19 64.11 87.96
 Second trimester52.53 (9.94)26.70 45.4051.74 59.84 81.23
 Third trimester54.22 (11.08)27.31 45.68 54.12 62.50 89.22
 Entire pregnancy53.60 (6.22)26.04 49.85 53.46 57.49 72.62
NO2 exposure (ppb)
 First trimester24.13 (9.26)7.37 18.24 22.13 26.66 62.85
 Second trimester24.69 (8.51)8.40 19.02 22.77 27.70 60.92
 Third trimester25.34 (8.43)9.05 19.58 23.66 27.85 54.04
 Entire pregnancy24.69 (8.01)9.42 20.07 22.37 26.49 55.91
 First trimester11.49 (8.62)−5.824.749.9219.527.68
 Second trimester11.82 (8.29)−2.554.479.9919.8925.82
 Third trimester11.59 (8.55)−4.344.549.7419.1827.01
 Entire pregnancy11.63 (8.28)−3.744.799.9519.6826.66
 First trimester64.65 (8.64)46.1458.2464.2971.2783.38
 Second trimester64.25 (9.11)39.0358.6463.0070.7184.95
 Third trimester65.05 (8.13)49.1958.5865.3371.4383.21
 Entire pregnancy64.66 (8.31)44.7958.7663.8870.9483.26
Green space (m2)
 100-m buffer38.44 (49.40)0.005.7319.6247.47205.38
 200-m buffer62.00 (63.11)0.0013.0138.3198.49292.93
 300-m buffer132.52 (89.37)2.0352.42123.36184.36440.83
 500-m buffer336.67 (232.79)2.03111.83247.91538.30903.54
Abbreviations: SD, standard deviation.
Table 3. Risk of atopic dermatitis in 6-month-old children with prenatal exposure to ambient PM10/NO2 and green space in their area of residence.
Table 3. Risk of atopic dermatitis in 6-month-old children with prenatal exposure to ambient PM10/NO2 and green space in their area of residence.
Exposure VariableAtopic Dermatitis
UnadjustedAdjusted 1
OR (95% CI)OR (95% CI)
PM10 (10 μg/m3)
 First trimester1.195 (1.038–1.376) *1.219 (1.023–1.452) *
 Second trimester1.050 (0.881–1.253)0.927 (0.725–1.185)
 Third trimester0.834 (0.710–0.980) *0.975 (0.792–1.201)
 Entire pregnancy1.123 (0.844–1.493)1.096 (0.795–1.510)
NO2 (10 ppb)
 First trimester1.202 (1.002–1.444) *1.353 (1.027–1.782) *
 Second trimester1.045 (0.852–1.282)1.115 (0.839–1.480)
 Third trimester0.999 (0.811–1.230)1.254 (0.934–1.684)
 Entire pregnancy1.105 (0.891–1.369)1.269 (0.936–1.721)
Residential surrounding green space
 100-m buffer0.993 (0.993–1.001)0.997 (0.993–1.001)
 200-m buffer0.997 (0.994–0.999) *0.996 (0.993–0.999) *
 300-m buffer0.999 (0.996–0.999) *0.997 (0.995–0.999) *
 500-m buffer0.999 (0.999–1.000)0.999 (0.998–1.000)
Abbreviations: OR, odds ratios; CI, confidence interval; ppb, part per billion. 1 Adjusted for maternal age, education, income, body mass index, history of allergy, exposure to secondhand smoke, residential mobility, gestational age, the presence of pets, infant sex, birth weight, season of birth, breastfeeding, mode of delivery, temperature, and humidity. * Significant at p < 0.05.
Table 4. Risk of atopic dermatitis in 6-month-old children with exposure to ambient PM10/NO2 during the first trimester of pregnancy stratified by the level of green space in the residential area.
Table 4. Risk of atopic dermatitis in 6-month-old children with exposure to ambient PM10/NO2 during the first trimester of pregnancy stratified by the level of green space in the residential area.
Green Space in Residential Area (m2) 1nAtopic Dermatitis
PM10 during 1st Trimester (10 μg/m3)NO2 during 1st Trimester (10 ppb)
Unadjusted OR
(95% CI)
Adjusted 2 OR
(95% CI)
Unadjusted OR
(95% CI)
Adjusted 2 OR
(95% CI)
100-m buffer
 Tertile 1 (<11.1)2201.289 (1.025–1.621) *1.454 (1.079–1.959) *1.087 (0.828–1.426)1.453 (0.944–2.236)
 Tertile 2 (11.1–28.8)2211.055 (0.821–1.356)1.047 (0.739–1.482)1.189 (0.805–1.756)0.838 (0.420–1.675)
 Tertile 3 (>28.8)2181.174 (0.901–1.530)0.938 (0.639–1.378)1.202 (0.752–1.921)1.281 (0.643–2.551)
200-m buffer
 Tertile 1 (<21.1)2201.284 (1.018–1.619) *1.581 (1.162–2.152) **1.169 (0.887–1.541)1.632 (1.050–2.538) *
 Tertile 2 (21.1–64.2)2201.174 (0.911–1.512)1.120 (0.813–1.542)1.060 (0.726–1.546)1.044 (0.568–1.919)
 Tertile 3 (>64.2)2191.058 (0.814–1.375)0.852 (0.575–1.261)1.284 (0.710–2.323)1.063 (0.468–2.411)
300-m buffer
 Tertile 1 (<63.3)2201.268 (1.002–1.604) *1.455 (1.063–1.993) *1.140 (0.872–1.491)1.506 (0.973–2.330)
 Tertile 2 (63.3–171.5)2201.042 (0.815–1.330)1.183 (0.858–1.631)0.935 (0.618–1.413)1.020 (0.538–1.934)
 Tertile 3 (>171.5)2191.196 (0.910–1.572)0.995 (0.679–1.458)1.411 (0.833–2.391)1.599 (0.723–3.537)
500-m buffer
 Tertile 1 (<158.5)2201.356 (1.068–1.721) *1.451 (1.076–1.957) *1.171 (0.892–1.537)1.330 (0.877–2.017)
 Tertile 2 (158.5–444.8)2201.107 (0.847–1.446)1.246 (0.961–1.803)0.998 (0.643–1.550)1.066 (0.563–2.020)
 Tertile 3 (>444.8)2191.076 (0.836–1.385)1.005 (0.716–1.409)1.434 (0.911–2.225)1.882 (0.857–4.133)
Abbreviations: OR, odds ratios; CI, confidence interval; ppb part per billion. 1 The individual green space size within the buffer area. The distribution of green space was divided into tertiles. 2 Adjusted for maternal age, education, income, body mass index, history of allergy, exposure to secondhand smoke, residential mobility, gestational age, the presence of pets, infant sex, birth weight, season of birth, breastfeeding, mode of delivery, temperature, and humidity. * Significant at p < 0.05, ** p < 0.01.

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