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Unusual Onset of Celiac Disease and Addison’s Disease in a 12-Year-Old Boy

Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy
Pediatric Highly Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy
Paediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2017, 14(8), 855;
Received: 4 July 2017 / Revised: 26 July 2017 / Accepted: 28 July 2017 / Published: 29 July 2017
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
PDF [392 KB, uploaded 1 August 2017]


Background: Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison’s disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD. Case presentation: A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here. A gluten-free diet had a significant therapeutic role in this case, wherein most of the clinical signs and symptoms of AD disappeared in a few days. In addition, the dosage of cortisol acetate, initially administered to treat the AD, was able to be rapidly reduced. Conclusion: This case highlights that CD can be associated with AD in children, and a gluten-free diet seems to positively influence the course of AD. View Full-Text
Keywords: Addison’s disease; autoimmune diseases; celiac disease; gluten-free diet Addison’s disease; autoimmune diseases; celiac disease; gluten-free diet

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Miconi, F.; Savarese, E.; Miconi, G.; Cabiati, G.; Rapaccini, V.; Principi, N.; Esposito, S. Unusual Onset of Celiac Disease and Addison’s Disease in a 12-Year-Old Boy. Int. J. Environ. Res. Public Health 2017, 14, 855.

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