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Int. J. Environ. Res. Public Health 2016, 13(1), 38;

Profile of HIV-Infected Hispanics with Pancytopenia

Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA
Author to whom correspondence should be addressed.
Academic Editors: Mark Edberg, Barbara E. Hayes, Valerie Montgomery Rice and Paul B. Tchounwou
Received: 15 August 2015 / Revised: 27 October 2015 / Accepted: 5 November 2015 / Published: 22 December 2015
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Pancytopenia is seen in late HIV infection; it is associated with medical complications and with decreased survival. We determined the prevalence of pancytopenia at baseline in a cohort of HIV-positive Hispanics living in Puerto Rico, and compared their socio-demographic, immunological and clinical characteristics. A total of 1202 patients enrolled between 2000 and 2010 were included. They were grouped according to pancytopenia status, defined by having: platelets <150,000 μL, white cell count <4000 μL, and hemoglobin <12 g/dL (women) or <13 g/dL (men). Differences were evaluated using Student’s t-test, Chi-square test and Kaplan-Meier method. The prevalence of pancytopenia was 8.7%. Patients with pancytopenia had lower BMI and lower CD4 count, as well as higher HIV viral load and higher proportions of unemployment, clinical AIDS and antiretroviral treatment (ART) use (p < 0.05). One-year mortality rate was significantly higher in patients with pancytopenia (18.1% vs. 5.1%, p < 0.001). When stratifying for ART this association persisted for patients who did not receive ART (41.4% vs. 5.2%, p < 0.001), but it was not seen in patients who received treatment (9.2% vs. 5.6%, p = 0.196). Pancytopenia was associated with elements of advanced stages of HIV. ART could reduce the mortality of HIV-patients with pancytopenia to levels comparable to patients without the disorders. View Full-Text
Keywords: HIV; Hispanics; blood disorders; pancytopenia; antiretroviral treatment; prevalence; mortality HIV; Hispanics; blood disorders; pancytopenia; antiretroviral treatment; prevalence; mortality

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Santiago-Rodríguez, E.J.; Mayor, A.M.; Fernández-Santos, D.M.; Hunter-Mellado, R.F. Profile of HIV-Infected Hispanics with Pancytopenia. Int. J. Environ. Res. Public Health 2016, 13, 38.

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