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Article

Profile of HIV-Infected Hispanics with Pancytopenia

Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA
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Academic Editors: Mark Edberg, Barbara E. Hayes, Valerie Montgomery Rice and Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2016, 13(1), 38; https://doi.org/10.3390/ijerph13010038
Received: 15 August 2015 / Revised: 27 October 2015 / Accepted: 5 November 2015 / Published: 22 December 2015
Pancytopenia is seen in late HIV infection; it is associated with medical complications and with decreased survival. We determined the prevalence of pancytopenia at baseline in a cohort of HIV-positive Hispanics living in Puerto Rico, and compared their socio-demographic, immunological and clinical characteristics. A total of 1202 patients enrolled between 2000 and 2010 were included. They were grouped according to pancytopenia status, defined by having: platelets <150,000 μL, white cell count <4000 μL, and hemoglobin <12 g/dL (women) or <13 g/dL (men). Differences were evaluated using Student’s t-test, Chi-square test and Kaplan-Meier method. The prevalence of pancytopenia was 8.7%. Patients with pancytopenia had lower BMI and lower CD4 count, as well as higher HIV viral load and higher proportions of unemployment, clinical AIDS and antiretroviral treatment (ART) use (p < 0.05). One-year mortality rate was significantly higher in patients with pancytopenia (18.1% vs. 5.1%, p < 0.001). When stratifying for ART this association persisted for patients who did not receive ART (41.4% vs. 5.2%, p < 0.001), but it was not seen in patients who received treatment (9.2% vs. 5.6%, p = 0.196). Pancytopenia was associated with elements of advanced stages of HIV. ART could reduce the mortality of HIV-patients with pancytopenia to levels comparable to patients without the disorders. View Full-Text
Keywords: HIV; Hispanics; blood disorders; pancytopenia; antiretroviral treatment; prevalence; mortality HIV; Hispanics; blood disorders; pancytopenia; antiretroviral treatment; prevalence; mortality
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MDPI and ACS Style

Santiago-Rodríguez, E.J.; Mayor, A.M.; Fernández-Santos, D.M.; Hunter-Mellado, R.F. Profile of HIV-Infected Hispanics with Pancytopenia. Int. J. Environ. Res. Public Health 2016, 13, 38. https://doi.org/10.3390/ijerph13010038

AMA Style

Santiago-Rodríguez EJ, Mayor AM, Fernández-Santos DM, Hunter-Mellado RF. Profile of HIV-Infected Hispanics with Pancytopenia. International Journal of Environmental Research and Public Health. 2016; 13(1):38. https://doi.org/10.3390/ijerph13010038

Chicago/Turabian Style

Santiago-Rodríguez, Eduardo J., Angel M. Mayor, Diana M. Fernández-Santos, and Robert F. Hunter-Mellado 2016. "Profile of HIV-Infected Hispanics with Pancytopenia" International Journal of Environmental Research and Public Health 13, no. 1: 38. https://doi.org/10.3390/ijerph13010038

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