1. Introduction
2. Ethics Statement
3. Methods and Results
Parameters | Estimates | References | |
---|---|---|---|
: New HIV infections in San Diego country among MSM (N per year) | 339 | [2] | |
: Frequency of seminal CMV shedding among MSM (%) | 51.3% | [11,12] | |
: Frequency of HIV transmission in partnerships with CMV shedding detected in the potential source partner (N (%)) | 16/30 (53.3%) | [14] | |
: Frequency of HIV transmission in partnerships with CMV shedding not detected in the potential source partner (N (%)) | 4/16 (25%) | [14] | |
Estimated number of new HIV infections attributable to CMV (%) | 125 (36.8%) | ||
: Frequency of bacterial STI among MSM (%) | 15% | [12] | |
: Frequency of HIV transmission in partnerships with bacterial STI in the potential source partner (N (%)) | 5/5 (100%) | [14] | |
: Frequency of HIV transmission in partnerships without bacterial STI in the potential source partner (N (%)) | 15/41 (37%) | [14] | |
Estimated number of new HIV infections attributable to bacterial STI (%) | 70 (20.6%) | ||
: Frequency of HSV-2 seropositivity among MSM (%) | 41% | [19] | |
: Frequency of HIV transmission in partnerships with positive HSV-2 serology in the potential source partner (N (%)) | 8/19 (42%) | 8/19 (42%) | [15] |
: Frequency of HIV transmission in partnerships with negative HSV-2 serology in the potential source partner (N (%)) | 7/25 (28%) | [15] | |
Estimated number of new HIV infections attributable to HSV-2 (%) | 58 (17.1%) |
4. Discussion
5. Conclusions
Acknowledgements
Author Contributions
Conflicts of Interest
References
- Maartens, G.; Celum, C.; Lewin, S.R. HIV infection: Epidemiology, pathogenesis, treatment, and prevention. Lancet 2014, 384, 258–271. [Google Scholar] [CrossRef]
- County of San Diego, Health and Human Services Agency (HHSA). Monthly STD Report. Available online: http://sdcounty.ca.gov/hhsa/programs/phs/documents/STDMonthlyReport_Vol_6_Issue_1.pdf (accessed on 3 July 2015).
- Reynolds, S.J.; Makumbi, F.; Nakigozi, G.; Kagaayi, J.; Gray, R.H.; Wawer, M.; Quinn, T.C.; Serwadda, D. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS 2011, 25, 473–477. [Google Scholar] [CrossRef] [PubMed]
- Attia, S.; Egger, M.; Muller, M.; Zwahlen, M.; Low, N. Sexual transmission of HIV according to viral load and antiretroviral therapy: Systematic review and meta-analysis. AIDS 2009, 23, 1397–1404. [Google Scholar] [CrossRef] [PubMed]
- Ward, H.; Ronn, M. Contribution of sexually transmitted infections to the sexual transmission of HIV. Curr. Opin. HIV AIDS 2010, 5, 305–310. [Google Scholar] [CrossRef] [PubMed]
- Boddiger, D. Metamphetamine use linked to rising HIV transmission. Lancet 2005, 365, 1217–1278. [Google Scholar] [CrossRef]
- Lisco, A.; Vanpouille, C.; Margolis, L. Coinfecting viruses as determinants of HIV disease. Curr. HIV/AIDS Rep. 2009, 6, 5–12. [Google Scholar] [CrossRef] [PubMed]
- Galvin, S.R.; Cohen, M.S. The role of sexually transmitted diseases in HIV transmission. Nat. Rev. Microbiol. 2004, 2, 33–42. [Google Scholar] [CrossRef] [PubMed]
- Baggaley, R.F.; White, R.G.; Boily, M.C. HIV transmission risk through anal intercourse: Systematic review, meta-analysis and implications for HIV prevention. Int. J. Epidemiol. 2010, 39, 1048–1063. [Google Scholar] [CrossRef] [PubMed]
- Celum, C.; Wald, A.; Lingappa, J.R.; Magaret, A.S.; Wang, R.S.; Mugo, N.; Mujugira, A.; Baeten, J.M.; Mullins, J.I.; Hughes, J.P.; et al. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N. Engl. J. Med. 2010, 362, 427–439. [Google Scholar] [CrossRef] [PubMed]
- Gianella, S.; Morris, S.R.; Anderson, C.; Spina, C.A.; Vargas, M.V.; Young, J.A.; Richman, D.D.; Little, S.J.; Smith, D.M. Herpesviruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract. AIDS 2013, 27, 39–47. [Google Scholar] [CrossRef] [PubMed]
- Gianella, S.; Smith, D.M.; Vargas, M.V.; Little, S.J.; Richman, D.D.; Daar, E.S.; Dube, M.P.; Zhang, F.; Ginocchio, C.C.; Haubrich, R.H.; et al. Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men. Clin. Infect. Dis. 2013, 57, 441–447. [Google Scholar] [CrossRef] [PubMed]
- Johnson, E.L.; Howard, C.L.; Thurman, J.; Pontiff, K.; Johnson, E.S.; Chakraborty, R. CMV upregulates expression of CCR5 in central memory TCM cord blood mononuclear cells which may facilitate in utero HIV-1 transmission. J. Infect. Dis. 2015, 211, 187–196. [Google Scholar] [CrossRef] [PubMed]
- Gianella, S.; Morris, S.R.; Vargas, M.V.; Young, J.A.; Callahan, B.; Richman, D.D.; Little, S.J.; Smith, D.M. The role of seminal shedding of herpesviruses in HIV-1 transmission. J. Infect. Dis. 2012, 207, 257–261. [Google Scholar] [CrossRef] [PubMed]
- Butler, D.M.; Smith, D.M.; Cachay, E.R.; Hightower, G.K.; Nugent, C.T.; Richman, D.D.; Little, S.J. Herpes simplex virus 2 serostatus and viral loads of HIV-1 in blood and semen as risk factors for HIV transmission among men who have sex with men. AIDS 2008, 22, 1667–1671. [Google Scholar] [CrossRef] [PubMed]
- Butler, D.M.; Delport, W.; Kosakovsky Pond, S.L.; Lakdawala, M.K.; Cheng, P.M.; Little, S.J.; Richman, D.D.; Smith, D.M. The origins of sexually transmitted HIV among men who have sex with men. Sci. Trans. Med. 2010, 2. [Google Scholar] [CrossRef] [PubMed]
- Morris, S.R.; Little, S.J.; Cunningham, T.; Garfein, R.S.; Richman, D.D.; Smith, D.M. Evaluation of an HIV nucleic acid testing program with automated Internet and voicemail systems to deliver results. Ann. Intern. Med. 2010, 152, 778–785. [Google Scholar] [CrossRef] [PubMed]
- Hightower, G.K.; May, S.J.; Perez-Santiago, J.; Pacold, M.E.; Wagner, G.A.; Little, S.J.; Richman, D.D.; Mehta, S.R.; Smith, D.M.; Pond, S.L. HIV-1 clade B pol evolution following primary infection. PLoS ONE 2013, 8. [Google Scholar] [CrossRef] [PubMed]
- Cachay, E.R.; Frost, S.D.; Poon, A.F.; Looney, D.; Rostami, S.M.; Pacold, M.E.; Richman, D.D.; Little, S.J.; Smith, D.M. Herpes simplex virus type 2 acquisition during recent HIV infection does not influence plasma HIV levels. J. Acquir. Immune Defic. Syndr. 2008, 47, 592–596. [Google Scholar] [CrossRef] [PubMed]
- Altman, D.G. Practical Statistics for Medical Research; CRC Press: Boca Raton, FL, USA, 1991. [Google Scholar]
- Center for Disease Control and Prevention. HIV Surveillance Report. Available online: http://www.cdc.gov/hiv/library/reports/surveillance/index.html (accessed on 3 July 2015).
- Wald, A.; Link, K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: A meta-analysis. J. Infect. Dis. 2002, 185, 45–52. [Google Scholar] [CrossRef] [PubMed]
- Posavad, C.M.; Zhao, L.; Mueller, D.E.; Stevens, C.E.; Huang, M.; Wald, A.; Corey, L. Persistence of mucosal T-cell responses to herpes simplex virus type 2 in the female genital tract. Mucosal. Immunol. 2015, 8, 115–126. [Google Scholar] [CrossRef] [PubMed]
- Schiffer, J.T.; Corey, L. Rapid host immune response and viral dynamics in herpes simplex virus-2 infection. Nat. Med. 2013, 19, 280–290. [Google Scholar] [CrossRef] [PubMed]
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