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Open AccessArticle

Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population

Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China
Department of Nephrology, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, China
Wanzai Hospital of Xiangzhou district, Zhuhai 519000, China
Qianjin health service center of Tianhe district, Guangzhou 510000, China
Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2014, 11(8), 7622-7635;
Received: 12 May 2014 / Revised: 8 July 2014 / Accepted: 10 July 2014 / Published: 29 July 2014
Aim: To examine the association of serum lipids, lipid ratios with Chronic Kidney Disease (CKD) in a Chinese population. Methods: Data were drawn from a cross-sectional survey in China. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 or albuminuria-to-creatinine ratio (ACR) > 30 mg/g. Multivariable logistic regressions and multivariate regression models were used. Serum lipids and lipid ratios included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio. Results: In men, only logarithm-transformed (log) TG was associated with CKD. The odds ratio (every SD increment) was 1.39 (95% CI 1.03–1.87, P = 0.03). In women, none of the serum lipids and lipid ratios was associated with CKD. Using multivariate regression models, it was shown that log TG and log TG/HDL-C were negatively correlated with eGFR (P < 0.05) in men and LDL-C and log LDL-C/HDL-C ratio were correlated with ACR in men. In female subjects, serum TC, log TG, log TG/HDL-C and log TC/HDL-C were negatively correlated with eGFR (P < 0.05). All of serum lipid profiles and lipid related ratio were not correlated with ACR in women. Conclusion: Serum TG is the only suitable predictor for CKD in men. However, in women, none of serum lipids and lipid ratio can be used as a predictor for CKD. Log TG and log TG/HDL-C are negatively correlated with eGFR in both genders. View Full-Text
Keywords: serum lipids; lipid ratios; chronic kidney disease serum lipids; lipid ratios; chronic kidney disease
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Zhang, L.; Yuan, Z.; Chen, W.; Chen, S.; Liu, X.; Liang, Y.; Shao, X.; Zou, H. Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population. Int. J. Environ. Res. Public Health 2014, 11, 7622-7635.

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