Next Article in Journal
Strategies to Minimize Antibiotic Resistance
Next Article in Special Issue
Assessment of Infantile Mineral Imbalances in Autism Spectrum Disorders (ASDs)
Previous Article in Journal
Interference in Pheromone-Responsive Conjugation of a High-Level Bacitracin Resistant Enterococcus faecalis Plasmid of Poultry Origin
Previous Article in Special Issue
Infertility and Its Treatments in Association with Autism Spectrum Disorders: A Review and Results from the CHARGE Study

Epigenetic Findings in Autism: New Perspectives for Therapy

Department of Experimental Medicine, Second University of Naples; via S. Maria di Costantinopoli, Napoli 16-80138, Italy
Centre for Autism—La Forza del Silenzio, Caserta 81036, Italy
Cancellautismo—Non-Profit Association for Autism Care, Florence 50132, Italy
Institute of Protein Biochemistry, National Research Council of Italy,Naples 80128, Italy
International Child Development Resource Center, Chateau Elan 30517, USA
Biomedical Centre for Autism Research and Treatment, Bari 70126, Italy
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2013, 10(9), 4261-4273;
Received: 21 June 2013 / Revised: 14 August 2013 / Accepted: 6 September 2013 / Published: 11 September 2013
(This article belongs to the Special Issue The Environment Risk of Autism)
Autism and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders characterized by dysfunctions in social interactions, communications, restricted interests, and repetitive stereotypic behaviors. Despite extensive genetic and biological research, significant controversy surrounds our understanding of the specific mechanisms of their pathogenesis. However, accumulating evidence points to the involvement of epigenetic modifications as foundational in creating ASD pathophysiology. Epigenetic modifications or the alteration of DNA transcription via variations in DNA methylation and histone modifications but without alterations in the DNA sequence, affect gene regulation. These alterations in gene expression, obtained through DNA methylation and/or histone modifications, result from transcriptional regulatory influences of environmental factors, such as nutritional deficiencies, various toxicants, immunological effects, and pharmaceuticals. As such these effects are epigenetic regulators which determine the final biochemistry and physiology of the individual. In contrast to psychopharmacological interventions, bettering our understanding of how these gene-environmental interactions create autistic symptoms should facilitate the development of therapeutic targeting of gene expression for ASD biomedical care. View Full-Text
Keywords: autism; gene expression; environmental factors autism; gene expression; environmental factors
MDPI and ACS Style

Siniscalco, D.; Cirillo, A.; Bradstreet, J.J.; Antonucci, N. Epigenetic Findings in Autism: New Perspectives for Therapy. Int. J. Environ. Res. Public Health 2013, 10, 4261-4273.

AMA Style

Siniscalco D, Cirillo A, Bradstreet JJ, Antonucci N. Epigenetic Findings in Autism: New Perspectives for Therapy. International Journal of Environmental Research and Public Health. 2013; 10(9):4261-4273.

Chicago/Turabian Style

Siniscalco, Dario, Alessandra Cirillo, James J. Bradstreet, and Nicola Antonucci. 2013. "Epigenetic Findings in Autism: New Perspectives for Therapy" International Journal of Environmental Research and Public Health 10, no. 9: 4261-4273.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop