Next Article in Journal
Bacterial Diversity and Bioprospecting for Cold-Active Hydrolytic Enzymes from Culturable Bacteria Associated with Sediment from Nella Fjord, Eastern Antarctica
Previous Article in Journal
Antiproliferative and Antiangiogenic Activities of Smenospongine, a Marine Sponge Sesquiterpene Aminoquinone
Article Menu

Export Article

Open AccessArticle

New Cytotoxic Oxygenated Sterols from the Marine Bryozoan Cryptosula pallasiana

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shannxi, China
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China
Jiangsu Center for Drug Screening & National Drug Screening Laboratory, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
Authors to whom correspondence should be addressed.
Mar. Drugs 2011, 9(2), 162-183;
Received: 18 December 2010 / Revised: 13 January 2011 / Accepted: 24 January 2011 / Published: 28 January 2011
PDF [1470 KB, uploaded 24 February 2015]


Six new sterols (16), together with seven known sterols (713), were isolated from the CCl4 extract of the marine bryozoan Cryptosula pallasiana, four (36) of which have already been reported as synthetic sterols. This is the first time that these compounds (36) are reported as natural sterols. The structures of the new compounds were determined on the basis of the extensive spectroscopic analysis, including two-dimensional (2D) NMR and HR-ESI-MS data. Compounds 14, 7 and 1013 were evaluated for their cytotoxicity against HL-60 human myeloid leukemia cell line, and all of the evaluated compounds exhibited moderate cytotoxicity to HL-60 cells with a range of IC50 values from 14.73 to 22.11 µg/mL except for compounds 12 and 13. View Full-Text
Keywords: marine bryozoan; Cryptosula pallasiana; oxygenated sterols; cytotoxicity marine bryozoan; Cryptosula pallasiana; oxygenated sterols; cytotoxicity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Tian, X.-R.; Tang, H.-F.; Li, Y.-S.; Lin, H.-W.; Chen, X.-L.; Ma, N.; Yao, M.-N.; Zhang, P.-H. New Cytotoxic Oxygenated Sterols from the Marine Bryozoan Cryptosula pallasiana. Mar. Drugs 2011, 9, 162-183.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top