Angiotensin-I-Converting Enzyme (ACE) Inhibitors from Marine Resources: Prospects in the Pharmaceutical Industry
1
Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Korea
2
Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2010, 8(4), 1080-1093; https://doi.org/10.3390/md8041080
Received: 19 February 2010
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Accepted: 29 March 2010
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Published: 31 March 2010
Hypertension or high blood pressure is one of the major independent risk factors for cardiovascular diseases. Angiotensin-I-converting enzyme (EC 3.4.15.1; ACE) plays an important physiological role in regulation of blood pressure by converting angiotensin I to angiotensin II, a potent vasoconstrictor. Therefore, the inhibition of ACE activity is a major target in the prevention of hypertension. Recently, the search for natural ACE inhibitors as alternatives to synthetic drugs is of great interest to prevent several side effects and a number of novel compounds such as bioactive peptides, chitooligosaccharide derivatives (COS) and phlorotannins have been derived from marine organisms as potential ACE inhibitors. These inhibitory derivatives can be developed as nutraceuticals and pharmaceuticals with potential to prevent hypertension. Hence, the aim of this review is to discuss the marine-derived ACE inhibitors and their future prospects as novel therapeutic drug candidates for treat hypertension.
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Keywords:
angiotensin-I-converting enzyme inhibitors; antihypertensive activity; bioactive peptides; chitooligosaccharides; hypertension; phlorotannins
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MDPI and ACS Style
Wijesekara, I.; Kim, S.-K. Angiotensin-I-Converting Enzyme (ACE) Inhibitors from Marine Resources: Prospects in the Pharmaceutical Industry. Mar. Drugs 2010, 8, 1080-1093. https://doi.org/10.3390/md8041080
AMA Style
Wijesekara I, Kim S-K. Angiotensin-I-Converting Enzyme (ACE) Inhibitors from Marine Resources: Prospects in the Pharmaceutical Industry. Marine Drugs. 2010; 8(4):1080-1093. https://doi.org/10.3390/md8041080
Chicago/Turabian StyleWijesekara, Isuru, and Se-Kwon Kim. 2010. "Angiotensin-I-Converting Enzyme (ACE) Inhibitors from Marine Resources: Prospects in the Pharmaceutical Industry" Marine Drugs 8, no. 4: 1080-1093. https://doi.org/10.3390/md8041080
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