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Cyclodepsipeptides from Marine Sponges: Natural Agents for Drug Research

Department of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria
Author to whom correspondence should be addressed.
Mar. Drugs 2010, 8(3), 810-834;
Received: 5 February 2010 / Revised: 4 March 2010 / Accepted: 19 March 2010 / Published: 22 March 2010
(This article belongs to the Special Issue Bioactive Compound from Marine Sponges)
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A number of natural products from marine sponges, such as cyclodepsipeptides, have been identified. The structural characteristics of this family of cyclic peptides include various unusual amino acid residues and unique N-terminal polyketide-derived moieties. Papuamides are representatives of a class of marine sponge derived cyclic depsipeptides, including callipeltin A, celebesides A and B, homophymine A, mirabamides, microspinosamide, neamphamide A and theopapuamides. They are thought to have cytoprotective activity against HIV-1 in vitro by inhibiting viral entry. Jasplakinolide, a representative member of marine sponge-derived cyclodepsipeptides that include arenastatin A, geodiamolides, homophymines, spongidepsin and theopapuamides, is a potent inducer of actin polymerization in vitro. Although actin dynamics is essential for tumor metasasis, no actin targeting drugs have been used in clinical trials due to their severe cytotoxicity. Nonetheless, the actin cytoskeleton remains a potential target for anti-cancer drug development. These features imply the use of cyclodepsipeptides as molecular models in drug research. View Full-Text
Keywords: cyclodepsipeptides; papuamides; jasplakinolide; actin polymerisation; HIV entry inhibitors cyclodepsipeptides; papuamides; jasplakinolide; actin polymerisation; HIV entry inhibitors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Andavan, G.S.B.; Lemmens-Gruber, R. Cyclodepsipeptides from Marine Sponges: Natural Agents for Drug Research. Mar. Drugs 2010, 8, 810-834.

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