Next Article in Journal
Seaweed Phenolics: From Extraction to Applications
Next Article in Special Issue
Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents
Previous Article in Journal
13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity against Oral Cancer Cells through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts
Previous Article in Special Issue
Modulation of Glial Responses by Furanocembranolides: Leptolide Diminishes Microglial Inflammation in Vitro and Ameliorates Gliosis In Vivo in a Mouse Model of Obesity and Insulin Resistance
Open AccessArticle

Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908)

by Yi-Lin Zhang 1,2,†, Chih-Chao Chiang 3,†, Yi-Ting Lee 4, Zhi-Hong Wen 4,5, Yang-Chang Wu 6,7, Yu-Jen Wu 8, Tsong-Long Hwang 9,10,11,12,13, Tung-Ying Wu 14,15,*, Chia-Yuan Chang 16,* and Ping-Jyun Sung 1,2,4,7,17,*
1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan
3
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan
4
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
5
Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
6
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan
7
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404394, Taiwan
8
Department of Nursing, Meiho University, Pingtung 912009, Taiwan
9
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan
10
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan
11
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333323, Taiwan
12
Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan
13
Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan
14
Department of Biological Science & Technology, Meiho University, Pingtung 912009, Taiwan
15
Department of Food Science and Nutrition, Meiho University, Pingtung 912009, Taiwan
16
Department of Neurosurgery, Antai Medical Care Corporation Antai Tian-Sheng Memorial Hospital, Pingtung 928004, Taiwan
17
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2020, 18(8), 383; https://doi.org/10.3390/md18080383
Received: 6 July 2020 / Revised: 17 July 2020 / Accepted: 20 July 2020 / Published: 24 July 2020
(This article belongs to the Special Issue Marine Compounds and Inflammation II)
Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (14). The structures of new metabolites 14 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS). View Full-Text
Keywords: Briareum stechei; briarane; briarenol; iNOS; COX-2 Briareum stechei; briarane; briarenol; iNOS; COX-2
Show Figures

Figure 1

MDPI and ACS Style

Zhang, Y.-L.; Chiang, C.-C.; Lee, Y.-T.; Wen, Z.-H.; Wu, Y.-C.; Wu, Y.-J.; Hwang, T.-L.; Wu, T.-Y.; Chang, C.-Y.; Sung, P.-J. Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908). Mar. Drugs 2020, 18, 383.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop