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Open AccessCommunication

Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model

1
Charles River Laboratories, Bristol BS20 7AW, UK
2
KWS BioTest Ltd., Bristol BS20 7LZ, UK
3
Marinova, 249 Kennedy Drive, Cambridge 7170, Australia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(5), 246; https://doi.org/10.3390/md18050246
Received: 13 April 2020 / Revised: 1 May 2020 / Accepted: 7 May 2020 / Published: 8 May 2020
Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged at 3.52 mg daily in a treatment model. Gross lung pathology (consolidation) was significantly reduced as compared to controls. UPF was then presented as a feed supplement at a rate of either nil, 3.52 mg/day or 7.04 mg/day in a prophylactic model, dosed three days before infection. A significant improvement was observed in the clinical signs of ill-health, as well as a reduction in gross lung pathology in animals treated with the higher dose, although there was no significant reduction in lung viral titres. View Full-Text
Keywords: anti-viral; fucoidan; influenza; inflammation; mice; lung; Undaria pinnatifida anti-viral; fucoidan; influenza; inflammation; mice; lung; Undaria pinnatifida
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Richards, C.; Williams, N.A.; Fitton, J.H.; Stringer, D.N.; Karpiniec, S.S.; Park, A.Y. Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model. Mar. Drugs 2020, 18, 246.

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