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Marine Drugs
Volume 18
Issue 5
10.3390/md18050246
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Communication

Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model

by
Claire Richards
1,
Neil A. Williams
2,
J. Helen Fitton
3,*,
Damien N. Stringer
3,
Samuel S. Karpiniec
3 and
Ah Young Park
3
1
Charles River Laboratories, Bristol BS20 7AW, UK
2
KWS BioTest Ltd., Bristol BS20 7LZ, UK
3
Marinova, 249 Kennedy Drive, Cambridge 7170, Australia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(5), 246; https://doi.org/10.3390/md18050246
Received: 13 April 2020 / Revised: 1 May 2020 / Accepted: 7 May 2020 / Published: 8 May 2020
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Abstract

Fucoidans are known to be effective inhibitors of inflammation, and of virus binding and cellular entry. Undaria pinnatifida-derived fucoidan (UPF) was assessed in a severe influenza A (H1N1, PR8) infection model in mice. Initially, UPF was gavaged at 3.52 mg daily in a treatment model. Gross lung pathology (consolidation) was significantly reduced as compared to controls. UPF was then presented as a feed supplement at a rate of either nil, 3.52 mg/day or 7.04 mg/day in a prophylactic model, dosed three days before infection. A significant improvement was observed in the clinical signs of ill-health, as well as a reduction in gross lung pathology in animals treated with the higher dose, although there was no significant reduction in lung viral titres. View Full-Text
Keywords: anti-viral; fucoidan; influenza; inflammation; mice; lung; Undaria pinnatifida anti-viral; fucoidan; influenza; inflammation; mice; lung; Undaria pinnatifida
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MDPI and ACS Style

Richards, C.; Williams, N.A.; Fitton, J.H.; Stringer, D.N.; Karpiniec, S.S.; Park, A.Y. Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model. Mar. Drugs 2020, 18, 246. https://doi.org/10.3390/md18050246

AMA Style

Richards C, Williams NA, Fitton JH, Stringer DN, Karpiniec SS, Park AY. Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model. Marine Drugs. 2020; 18(5):246. https://doi.org/10.3390/md18050246

Chicago/Turabian Style

Richards, Claire, Neil A. Williams, J. H. Fitton, Damien N. Stringer, Samuel S. Karpiniec, and Ah Y. Park. 2020. "Oral Fucoidan Attenuates Lung Pathology and Clinical Signs in a Severe Influenza A Mouse Model" Marine Drugs 18, no. 5: 246. https://doi.org/10.3390/md18050246

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