Next Article in Journal
Biomaterials Based on Marine Resources for 3D Bioprinting Applications
Previous Article in Journal
Conotoxin Diversity in the Venom Gland Transcriptome of the Magician’s Cone, Pionoconus magus
Open AccessReview

Marine Ligands of the Pregnane X Receptor (PXR): An Overview

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Heyrovského 1203, Hradec Králové 500 05, Czech Republic
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 554;
Received: 10 September 2019 / Revised: 27 September 2019 / Accepted: 27 September 2019 / Published: 28 September 2019
Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the expression of a wide array of genes and is involved in cancer and different key physiological processes such as the metabolism of drugs/xenobiotics and endogenous compounds including lipids and carbohydrates, and inflammation. Algae, sponges, sea squirts, and other marine organisms are some of the species from which structurally new molecules have been isolated that have been subsequently identified in recent decades as ligands for PXR. The therapeutic potential of these natural compounds is promising in different areas and has recently resulted in the registration of trabectedin by the FDA as a novel antineoplastic drug. Apart from being potentially novel drugs, these compounds can also serve as models for the development of new molecules with improved activity. The aim of this review is to succinctly summarize the currently known natural molecules isolated from marine organisms with a proven ability to interact with PXR. View Full-Text
Keywords: natural compound; marine origin; PXR; gene regulation; CYP450; inflammation; cancer natural compound; marine origin; PXR; gene regulation; CYP450; inflammation; cancer
Show Figures

Figure 1

MDPI and ACS Style

Carazo, A.; Mladěnka, P.; Pávek, P. Marine Ligands of the Pregnane X Receptor (PXR): An Overview. Mar. Drugs 2019, 17, 554.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop