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Mar. Drugs 2018, 16(9), 323; https://doi.org/10.3390/md16090323

Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways

1
Department of Otorhinolaryngology-Head & Neck Surgery, Inje University College of Medicine, Busan 47392, Korea
2
Department of Applied Research, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea
3
Department of Internal Medicine, Busan Paik Hospital, Inje University, Busan 47392, Korea
4
Department of Biomedical Engineering, Center for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong National University, Busan 48513, Korea
5
Department of Physiology, Kangwon National University School of Medicine, Chuncheon 24341, Korea
6
Department of Microbiology and Immunology, College of Medicine Inje University, Busan 47392, Korea
*
Authors to whom correspondence should be addressed.
Received: 14 August 2018 / Revised: 26 August 2018 / Accepted: 8 September 2018 / Published: 10 September 2018
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Abstract

Nasal polyps (NPs) are a multifactorial disorder associated with a chronic inflammatory state of the nasal mucosa. Fucoxanthin (Fx) is a characteristic orange carotenoid obtained from brown algae and has diverse immunological properties. The present study investigated whether Fx inhibits fibrosis-related effects in nasal polyp-derived fibroblasts (NPDFs) and elucidated the molecular signaling pathways involved. The production of collagen type I (Col-1) was investigated in NP tissue via immunohistochemistry and western blot analysis. NPDFs were treated with transforming growth factor (TGF)-β1 (1 ng/mL) in the presence or absence of Fx (5–30 µM). The levels of α-smooth muscle actin (α-SMA), Col-1, and phosphorylated (p)-Smad 2/3, signal protein-1 (SP-1), MAPKs (mitogen-activated protein kinases), and Akt were measured by western blot analysis. The expression of Col-1 was detected in NP tissues. TGF-β1 stimulated the production of α-SMA and Col-1, and stimulated the contraction of collagen gel. However, pretreatment with Fx attenuated these effects. Furthermore, these inhibitory effects were mediated through modulation of both Smad 2/3 and Akt/SP-1 signaling pathways in TGF-β1-induced NPDFs. The results from the present study suggest that Fx may be a novel anti-fibrotic agent for the treatment of NP formation. View Full-Text
Keywords: nasal polyps; fucoxantin; transforming growth factor; extracellular matrix accumulation; fibroblasts nasal polyps; fucoxantin; transforming growth factor; extracellular matrix accumulation; fibroblasts
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Jung, H.; Lee, D.-S.; Park, S.K.; Choi, J.S.; Jung, W.-K.; Park, W.S.; Choi, I.-W. Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways. Mar. Drugs 2018, 16, 323.

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