The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40T

Barrau, Clara; Di Lorenzo, Flaviana; Menes, Rodolfo Javier; Lanzetta, Rosa; Molinaro, Antonio; Silipo, Alba

doi:10.3390/md16040124

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The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40^T

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^1,*,

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Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy

Cátedra de Microbiología, Facultad de Química y Unidad Asociada de Facultad de Ciencias, Universidad de la República, 11800 Montevideo, Uruguay

Authors to whom correspondence should be addressed.

Mar. Drugs 2018, 16(4), 124; https://doi.org/10.3390/md16040124

Received: 17 March 2018 / Revised: 4 April 2018 / Accepted: 8 April 2018 / Published: 11 April 2018

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Abstract

The study of the adaptation mechanisms that allow microorganisms to live and proliferate in an extreme habitat is a growing research field. Directly exposed to the external environment, lipopolysaccharides (LPS) from Gram-negative bacteria are of great appeal as they can present particular structural features that may aid the understanding of the adaptation processes. Moreover, through being involved in modulating the mammalian immune system response in a structure-dependent fashion, the elucidation of the LPS structure can also be seen as a fundamental step from a biomedical point of view. In this paper, the lipid A structure of the LPS from Spiribacter salinus M19-40^T, a halophilic gamma-proteobacteria, was characterized through chemical analyses and matrix-assisted laser desorption ionization (MALDI) mass spectrometry. This revealed a mixture of mono- and bisphosphorylated penta- to tri-acylated species with the uncommon 2 + 3 symmetry and bearing an unusual 3-oxotetradecaonic acid. View Full-Text

Keywords: Spiribacter salinus; halophiles; Ectothiorhodospiraceae; lipopolysaccharide (LPS); lipid A; matrix-assisted laser desorption ionization (MALDI) mass spectrometry; 3-oxotetradecaonic acid

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MDPI and ACS Style

Barrau, C.; Di Lorenzo, F.; Menes, R.J.; Lanzetta, R.; Molinaro, A.; Silipo, A. The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40^T. Mar. Drugs 2018, 16, 124. https://doi.org/10.3390/md16040124

AMA Style

Barrau C, Di Lorenzo F, Menes RJ, Lanzetta R, Molinaro A, Silipo A. The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40^T. Marine Drugs. 2018; 16(4):124. https://doi.org/10.3390/md16040124

Chicago/Turabian Style

Barrau, Clara, Flaviana Di Lorenzo, Rodolfo Javier Menes, Rosa Lanzetta, Antonio Molinaro, and Alba Silipo. 2018. "The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40^T" Marine Drugs 16, no. 4: 124. https://doi.org/10.3390/md16040124

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The Structure of the Lipid A from the Halophilic Bacterium Spiribacter salinus M19-40^T

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