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Mar. Drugs 2018, 16(4), 114; https://doi.org/10.3390/md16040114

Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547

1
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Nanhai Road 7, Qingdao 266071, China
2
University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Received: 25 February 2018 / Revised: 27 March 2018 / Accepted: 30 March 2018 / Published: 31 March 2018
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes - II)
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Abstract

Chemical investigation of the marine algal-derived endophytic fungus Aspergillus alabamensis EN-547 resulted in the isolation of 4-epi-seco-shornephine A methyl ester (1) and 4-epi-seco-shornephine A carboxylic acid (2), two new secondary metabolites having a rare diketomorpholine motif, and 28-acetoxy-12β,15α,25-trihydroxyergosta-4,6,8(14),22-tetraen-3-one (3), a new highly conjugated ergostane-type steroid, together with four known metabolites (47). Their chemical structures were elucidated by detailed analysis of their NMR spectra, ECDs, HRESIMS, optical rotation, and X-ray crystallographic data, and by comparison with literature data as well. The antimicrobial activities of compounds 17 were evaluated. View Full-Text
Keywords: algal-derived endophytic fungus; Aspergillus alabamensis; diketomorpholine; steroid; antimicrobial activity algal-derived endophytic fungus; Aspergillus alabamensis; diketomorpholine; steroid; antimicrobial activity
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Yang, S.-Q.; Li, X.-M.; Li, X.; Chi, L.-P.; Wang, B.-G. Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547. Mar. Drugs 2018, 16, 114.

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