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New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006

Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 363-883, Korea
University of Science and Technology (UST), Daejeon 305-333, Korea
Chemical Biology Research Group, RIKEN Center for Sustainable Research Science, Saitama 351-0198, Japan
Korean Collection for Type Cultures, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56212, Korea
College of Pharmacy, Wonkwang University, Iksan 570-749, Korea
RIKEN-KRIBB Joint Research Unit, RIKRN Global Research Cluster, Saitama 351-0198, Japan
Authors to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2016, 14(4), 72;
Received: 15 February 2016 / Revised: 24 March 2016 / Accepted: 28 March 2016 / Published: 2 April 2016
PDF [1928 KB, uploaded 2 April 2016]


Salterns, one of the most extreme natural hypersaline environments, are a rich source of halophilic and halotolerant microorganisms, but they remain largely underexplored ecological niches in the discovery of bioactive secondary metabolites. In continued efforts to investigate the metabolic potential of microbial populations from chemically underexplored sites, three new lipopeptides named iturin F1, iturin F2 and iturin A9 (13), along with iturin A8 (4), were isolated from Bacillus sp. KCB14S006 derived from a saltern. The structures of the isolated compounds were established by 1D-, 2D-NMR and HR-ESIMS, and their absolute configurations were determined by applying advanced Marfey’s method and CD spectroscopy. All isolates exhibited significant antifungal activities against various pathogenic fungi and moderate cytotoxic activities toward HeLa and srcts-NRK cell lines. Moreover, in an in vitro enzymatic assay, compound 4 showed a significant inhibitory activity against indoleamine 2,3-dioxygenase. View Full-Text
Keywords: saltern-derived bacteria; iturins; antifungal; cytotoxic; indoleamine-2,3-dioxygenase saltern-derived bacteria; iturins; antifungal; cytotoxic; indoleamine-2,3-dioxygenase

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Son, S.; Ko, S.-K.; Jang, M.; Kim, J.W.; Kim, G.S.; Lee, J.K.; Jeon, E.S.; Futamura, Y.; Ryoo, I.-J.; Lee, J.-S.; Oh, H.; Hong, Y.-S.; Kim, B.Y.; Takahashi, S.; Osada, H.; Jang, J.-H.; Ahn, J.S. New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006. Mar. Drugs 2016, 14, 72.

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