Next Article in Journal / Special Issue
Fucoxanthinol, Metabolite of Fucoxanthin, Improves Obesity-Induced Inflammation in Adipocyte Cells
Previous Article in Journal
The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms
Previous Article in Special Issue
Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin
Article Menu

Export Article

Open AccessReview
Mar. Drugs 2015, 13(8), 4784-4798;

Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment

Biology Department, Université de Moncton, Moncton, NB E1A 3E9, Canada
Academic Editor: Peer B. Jacobson
Received: 4 June 2015 / Revised: 25 June 2015 / Accepted: 27 July 2015 / Published: 31 July 2015
(This article belongs to the Special Issue Marine Carotenoids and Oxidative Stress)
Full-Text   |   PDF [456 KB, uploaded 31 July 2015]   |  


Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. When ingested, it is metabolized mainly to fucoxanthinol by digestive enzymes of the gastrointestinal tract. These compounds have been shown to have many beneficial health effects, including anti-mutagenic, anti-diabetic, anti-obesity, anti-inflammatory and anti-neoplastic actions. In every cancer tested, modulatory actions of fucoxanthinol on viability, cell-cycle arrest, apoptosis and members of the NF-κB pathway were more pronounced than that of fucoxanthin. Anti-proliferative and cancer preventing influences of fucoxanthin and fucoxanthinol are mediated through different signalling pathways, including the caspases, Bcl-2 proteins, MAPK, PI3K/Akt, JAK/STAT, AP-1, GADD45, and several other molecules that are involved in cell cycle arrest, apoptosis, anti-angiogenesis or inhibition of metastasis. In this review, we address the mechanisms of action of fucoxanthin and fucoxanthinol according to different types of cancers. Current findings suggest that these compounds could be effective for treatment and/or prevention of cancer development and aggressiveness. View Full-Text
Keywords: fucoxanthin; fucoxanthinol; viability; apoptosis; cancer fucoxanthin; fucoxanthinol; viability; apoptosis; cancer

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Martin, L.J. Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment. Mar. Drugs 2015, 13, 4784-4798.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top