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A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats

1
Department of Clinical Science, University of Bergen, Bergen N-5020, Norway
2
Olympic Seafood AS, Fosnavåg N-6099, Norway
3
Department of Heart Disease, Haukeland University Hospital, Bergen N-5021, Norway
*
Author to whom correspondence should be addressed.
Academic Editor: Gilles Barnathan
Mar. Drugs 2015, 13(7), 4375-4397; https://doi.org/10.3390/md13074375
Received: 28 May 2015 / Revised: 24 June 2015 / Accepted: 1 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Marine Lipids)
Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2). Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2) was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. View Full-Text
Keywords: Antarctic krill; lipogenesis; plasma lipids; inflammation; antioxidant capacity; omega-3 polyunsaturated fatty acids; cholesterol; lipid lowering Antarctic krill; lipogenesis; plasma lipids; inflammation; antioxidant capacity; omega-3 polyunsaturated fatty acids; cholesterol; lipid lowering
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Ramsvik, M.S.; Bjørndal, B.; Bruheim, I.; Bohov, P.; Berge, R.K. A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats. Mar. Drugs 2015, 13, 4375-4397.

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