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Mar. Drugs 2014, 12(8), 4399-4416;

Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa

Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Department of Pharmacognosy and National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Dujiangyan Center of Aeromedical Assessment and Training of Air Force, Dujiangyan 611830, China
Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 16 June 2014 / Revised: 24 July 2014 / Accepted: 25 July 2014 / Published: 8 August 2014
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Five new norditerpene endoperoxides, named diacarperoxides H–L (15), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spectroscopic analyses, computational approaches and chemical degradation. Diacarperoxides H–J (13) showed some interesting stereochemical issues, as well as antimalarial activity. View Full-Text
Keywords: antimalarial; marine sponge; endoperoxide antimalarial; marine sponge; endoperoxide

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Yang, F.; Zou, Y.; Wang, R.-P.; Hamann, M.T.; Zhang, H.-J.; Jiao, W.-H.; Han, B.-N.; Song, S.-J.; Lin, H.-W. Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa. Mar. Drugs 2014, 12, 4399-4416.

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